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Items: 1 to 20 of 119

1.

Inhibition of phosphatidylinositol-3-OH kinase/Akt signaling impairs DNA repair in glioblastoma cells following ionizing radiation.

Kao GD, Jiang Z, Fernandes AM, Gupta AK, Maity A.

J Biol Chem. 2007 Jul 20;282(29):21206-12. Epub 2007 May 18.

2.

PKB/Akt mediates radiosensitization by the signaling inhibitor LY294002 in human malignant gliomas.

Nakamura JL, Karlsson A, Arvold ND, Gottschalk AR, Pieper RO, Stokoe D, Haas-Kogan DA.

J Neurooncol. 2005 Feb;71(3):215-22.

PMID:
15735908
3.

Phosphatase and tensin homologue deficiency in glioblastoma confers resistance to radiation and temozolomide that is reversed by the protease inhibitor nelfinavir.

Jiang Z, Pore N, Cerniglia GJ, Mick R, Georgescu MM, Bernhard EJ, Hahn SM, Gupta AK, Maity A.

Cancer Res. 2007 May 1;67(9):4467-73.

4.

MiR-20a Induces Cell Radioresistance by Activating the PTEN/PI3K/Akt Signaling Pathway in Hepatocellular Carcinoma.

Zhang Y, Zheng L, Ding Y, Li Q, Wang R, Liu T, Sun Q, Yang H, Peng S, Wang W, Chen L.

Int J Radiat Oncol Biol Phys. 2015 Aug 1;92(5):1132-40. doi: 10.1016/j.ijrobp.2015.04.007. Epub 2015 Apr 13.

PMID:
26031366
5.

A new selective AKT pharmacological inhibitor reduces resistance to chemotherapeutic drugs, TRAIL, all-trans-retinoic acid, and ionizing radiation of human leukemia cells.

Martelli AM, Tazzari PL, Tabellini G, Bortul R, Billi AM, Manzoli L, Ruggeri A, Conte R, Cocco L.

Leukemia. 2003 Sep;17(9):1794-805.

PMID:
12970779
6.

Reduced PTEN expression in breast cancer cells confers susceptibility to inhibitors of the PI3 kinase/Akt pathway.

DeGraffenried LA, Fulcher L, Friedrichs WE, Gr├╝nwald V, Ray RB, Hidalgo M.

Ann Oncol. 2004 Oct;15(10):1510-6.

7.

miR-221/222 confers radioresistance in glioblastoma cells through activating Akt independent of PTEN status.

Li W, Guo F, Wang P, Hong S, Zhang C.

Curr Mol Med. 2014 Jan;14(1):185-95.

PMID:
24295494
8.
9.

Blockage of epidermal growth factor receptor-phosphatidylinositol 3-kinase-AKT signaling increases radiosensitivity of K-RAS mutated human tumor cells in vitro by affecting DNA repair.

Toulany M, Kasten-Pisula U, Brammer I, Wang S, Chen J, Dittmann K, Baumann M, Dikomey E, Rodemann HP.

Clin Cancer Res. 2006 Jul 1;12(13):4119-26.

10.

PI3K-Akt signaling regulates basal, but MAP-kinase signaling regulates radiation-induced XRCC1 expression in human tumor cells in vitro.

Toulany M, Dittmann K, Fehrenbacher B, Schaller M, Baumann M, Rodemann HP.

DNA Repair (Amst). 2008 Oct 1;7(10):1746-56. doi: 10.1016/j.dnarep.2008.06.017. Epub 2008 Aug 22.

PMID:
18678286
11.

Combination of PTEN and gamma-ionizing radiation enhances cell death and G(2)/M arrest through regulation of AKT activity and p21 induction in non-small-cell lung cancer cells.

Park JK, Jung HY, Park SH, Kang SY, Yi MR, Um HD, Hong SH.

Int J Radiat Oncol Biol Phys. 2008 Apr 1;70(5):1552-60. doi: 10.1016/j.ijrobp.2007.11.069.

PMID:
18374229
12.

Activation of Akt/protein kinase B overcomes a G(2)/m cell cycle checkpoint induced by DNA damage.

Kandel ES, Skeen J, Majewski N, Di Cristofano A, Pandolfi PP, Feliciano CS, Gartel A, Hay N.

Mol Cell Biol. 2002 Nov;22(22):7831-41.

14.

DNA-PKcs plays a dominant role in the regulation of H2AX phosphorylation in response to DNA damage and cell cycle progression.

An J, Huang YC, Xu QZ, Zhou LJ, Shang ZF, Huang B, Wang Y, Liu XD, Wu DC, Zhou PK.

BMC Mol Biol. 2010 Mar 6;11:18. doi: 10.1186/1471-2199-11-18.

15.

Radiation-induced Akt activation modulates radioresistance in human glioblastoma cells.

Li HF, Kim JS, Waldman T.

Radiat Oncol. 2009 Oct 14;4:43. doi: 10.1186/1748-717X-4-43.

16.

Preferential killing of PTEN-null myelomas by PI3K inhibitors through Akt pathway.

Zhang J, Choi Y, Mavromatis B, Lichtenstein A, Li W.

Oncogene. 2003 Sep 18;22(40):6289-95.

PMID:
13679867
17.

Inhibition of ILK in PTEN-mutant human glioblastomas inhibits PKB/Akt activation, induces apoptosis, and delays tumor growth.

Edwards LA, Thiessen B, Dragowska WH, Daynard T, Bally MB, Dedhar S.

Oncogene. 2005 May 19;24(22):3596-605.

PMID:
15782140
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