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Results: 1 to 20 of 111

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1.

Mechanistic analysis of a suicide inactivator of histone demethylase LSD1.

Szewczuk LM, Culhane JC, Yang M, Majumdar A, Yu H, Cole PA.

Biochemistry. 2007 Jun 12;46(23):6892-902. Epub 2007 May 19.

2.

A Systematic Review of Histone Lysine-Specific Demethylase 1 and Its Inhibitors.

Zheng YC, Ma J, Wang Z, Li J, Jiang B, Zhou W, Shi X, Wang X, Zhao W, Liu HM.

Med Res Rev. 2015 May 19. doi: 10.1002/med.21350. [Epub ahead of print]

PMID:
25990136
3.

Extranucleosomal DNA enhances the activity of the LSD1/CoREST histone demethylase complex.

Kim SA, Chatterjee N, Jennings MJ, Bartholomew B, Tan S.

Nucleic Acids Res. 2015 May 26;43(10):4868-80. doi: 10.1093/nar/gkv388. Epub 2015 Apr 27.

4.

Histone H3 peptide based LSD1-selective inhibitors.

Kakizawa T, Ota Y, Itoh Y, Tsumoto H, Suzuki T.

Bioorg Med Chem Lett. 2015 May 1;25(9):1925-8. doi: 10.1016/j.bmcl.2015.03.030. Epub 2015 Mar 20.

PMID:
25827526
5.

Functional annotation of native enhancers with a Cas9-histone demethylase fusion.

Kearns NA, Pham H, Tabak B, Genga RM, Silverstein NJ, Garber M, Maehr R.

Nat Methods. 2015 May;12(5):401-3. doi: 10.1038/nmeth.3325. Epub 2015 Mar 16.

PMID:
25775043
6.

Measurement of lysine-specific demethylase-1 activity in the nuclear extracts by flow-injection based time-of-flight mass spectrometry.

Sakane C, Ohta H, Shidoji Y.

J Clin Biochem Nutr. 2015 Mar;56(2):123-31. doi: 10.3164/jcbn.14-99. Epub 2015 Feb 13.

7.

cis-cyclopropylamines as mechanism-based inhibitors of monoamine oxidases.

Malcomson T, Yelekci K, Borrello MT, Ganesan A, Semina E, De Kimpe N, Mangelinckx S, Ramsay RR.

FEBS J. 2015 Mar 9. doi: 10.1111/febs.13260. [Epub ahead of print]

PMID:
25755053
8.

Pure Diastereomers of a Tranylcypromine-Based LSD1 Inhibitor: Enzyme Selectivity and In-Cell Studies.

Valente S, Rodriguez V, Mercurio C, Vianello P, Saponara B, Cirilli R, Ciossani G, Labella D, Marrocco B, Ruoppolo G, Botrugno OA, Dessanti P, Minucci S, Mattevi A, Varasi M, Mai A.

ACS Med Chem Lett. 2014 Dec 8;6(2):173-7. doi: 10.1021/ml500424z. eCollection 2015 Feb 12.

PMID:
25699146
9.

Lysine Demethylase LSD1 Coordinates Glycolytic and Mitochondrial Metabolism in Hepatocellular Carcinoma Cells.

Sakamoto A, Hino S, Nagaoka K, Anan K, Takase R, Matsumori H, Ojima H, Kanai Y, Arita K, Nakao M.

Cancer Res. 2015 Apr 1;75(7):1445-56. doi: 10.1158/0008-5472.CAN-14-1560. Epub 2015 Feb 3.

PMID:
25649769
10.

Further insights into the SAR of α-substituted cyclopropylamine derivatives as inhibitors of histone demethylase KDM1A.

Pieroni M, Annunziato G, Azzali E, Dessanti P, Mercurio C, Meroni G, Trifiró P, Vianello P, Villa M, Beato C, Varasi M, Costantino G.

Eur J Med Chem. 2015 Mar 6;92:377-86. doi: 10.1016/j.ejmech.2014.12.032. Epub 2015 Jan 7.

PMID:
25585008
11.

3,5-Diamino-1,2,4-triazoles as a novel scaffold for potent, reversible LSD1 (KDM1A) inhibitors.

Kutz CJ, Holshouser SL, Marrow EA, Woster PM.

Medchemcomm. 2014 Dec;5(12):1863-1870.

PMID:
25580204
12.

Identification of Novel Selective Lysine-Specific Demethylase 1 (LSD1) Inhibitors Using a Pharmacophore-Based Virtual Screening Combined with Docking.

Zhou C, Kang D, Xu Y, Zhang L, Zha X.

Chem Biol Drug Des. 2015 Jun;85(6):659-71. doi: 10.1111/cbdd.12461. Epub 2014 Dec 22.

PMID:
25346381
13.

Synthesis, biological activity and mechanistic insights of 1-substituted cyclopropylamine derivatives: a novel class of irreversible inhibitors of histone demethylase KDM1A.

Vianello P, Botrugno OA, Cappa A, Ciossani G, Dessanti P, Mai A, Mattevi A, Meroni G, Minucci S, Thaler F, Tortorici M, Trifiró P, Valente S, Villa M, Varasi M, Mercurio C.

Eur J Med Chem. 2014 Oct 30;86:352-63. doi: 10.1016/j.ejmech.2014.08.068. Epub 2014 Aug 27.

PMID:
25173853
14.

Nuclear import of human histone lysine-specific demethylase LSD1.

Jin Y, Kim TY, Kim MS, Kim MA, Park SH, Jang YK.

J Biochem. 2014 Dec;156(6):305-13. doi: 10.1093/jb/mvu042. Epub 2014 Jul 1.

PMID:
24986870
15.

Synthesis and evaluation of novel cyclic Peptide inhibitors of lysine-specific demethylase 1.

Kumarasinghe IR, Woster PM.

ACS Med Chem Lett. 2013 Nov 8;5(1):29-33. doi: 10.1021/ml4002997. eCollection 2014 Jan 9.

16.

Crystal structure of the histone lysine specific demethylase LSD1 complexed with tetrahydrofolate.

Luka Z, Pakhomova S, Loukachevitch LV, Calcutt MW, Newcomer ME, Wagner C.

Protein Sci. 2014 Jul;23(7):993-8. doi: 10.1002/pro.2469. Epub 2014 Apr 18.

PMID:
24715612
17.

A selective phenelzine analogue inhibitor of histone demethylase LSD1.

Prusevich P, Kalin JH, Ming SA, Basso M, Givens J, Li X, Hu J, Taylor MS, Cieniewicz AM, Hsiao PY, Huang R, Roberson H, Adejola N, Avery LB, Casero RA Jr, Taverna SD, Qian J, Tackett AJ, Ratan RR, McDonald OG, Feinberg AP, Cole PA.

ACS Chem Biol. 2014 Jun 20;9(6):1284-93. doi: 10.1021/cb500018s. Epub 2014 Apr 7.

18.

Heterogeneous Antibody-Based Activity Assay for Lysine Specific Demethylase 1 (LSD1) on a Histone Peptide Substrate.

Schmitt ML, Ladwein KI, Carlino L, Schulz-Fincke J, Willmann D, Metzger E, Schilcher P, Imhof A, Schüle R, Sippl W, Jung M.

J Biomol Screen. 2014 Mar 31;19(6):973-978. [Epub ahead of print]

PMID:
24687155
19.

The lysine-specific demethylase 1 is a novel substrate of protein kinase CK2.

Costa R, Arrigoni G, Cozza G, Lolli G, Battistutta R, Izpisua Belmonte JC, Pinna LA, Sarno S.

Biochim Biophys Acta. 2014 Apr;1844(4):722-9. doi: 10.1016/j.bbapap.2014.01.014. Epub 2014 Jan 31.

PMID:
24486797
20.

Inhibition of lysine-specific demethylase 1 by the acyclic diterpenoid geranylgeranoic acid and its derivatives.

Sakane C, Okitsu T, Wada A, Sagami H, Shidoji Y.

Biochem Biophys Res Commun. 2014 Jan 31;444(1):24-9. doi: 10.1016/j.bbrc.2013.12.144. Epub 2014 Jan 7.

PMID:
24406160
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