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A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells.

Massey AJ, Williamson DS, Browne H, Murray JB, Dokurno P, Shaw T, Macias AT, Daniels Z, Geoffroy S, Dopson M, Lavan P, Matassova N, Francis GL, Graham CJ, Parsons R, Wang Y, Padfield A, Comer M, Drysdale MJ, Wood M.

Cancer Chemother Pharmacol. 2010 Aug;66(3):535-45. doi: 10.1007/s00280-009-1194-3. Epub 2009 Dec 13.


Dual targeting of HSC70 and HSP72 inhibits HSP90 function and induces tumor-specific apoptosis.

Powers MV, Clarke PA, Workman P.

Cancer Cell. 2008 Sep 9;14(3):250-62. doi: 10.1016/j.ccr.2008.08.002.


Tubocapsenolide A, a novel withanolide, inhibits proliferation and induces apoptosis in MDA-MB-231 cells by thiol oxidation of heat shock proteins.

Chen WY, Chang FR, Huang ZY, Chen JH, Wu YC, Wu CC.

J Biol Chem. 2008 Jun 20;283(25):17184-93. doi: 10.1074/jbc.M709447200. Epub 2008 Apr 28.


Epigallocatechin-3-gallate suppresses the expression of HSP70 and HSP90 and exhibits anti-tumor activity in vitro and in vivo.

Tran PL, Kim SA, Choi HS, Yoon JH, Ahn SG.

BMC Cancer. 2010 Jun 10;10:276. doi: 10.1186/1471-2407-10-276.


Ultrasound-targeted microbubble destruction combined with dual targeting of HSP72 and HSC70 inhibits HSP90 function and induces extensive tumor-specific apoptosis.

Wang H, Song Y, Hao D, Bai M, Jin L, Gu J, Su Y, Liu L, Jia C, Du L.

Int J Oncol. 2014 Jul;45(1):157-64. doi: 10.3892/ijo.2014.2388. Epub 2014 Apr 14.


Molecular characterization of heat shock protein 90, 70 and 70 cognate cDNAs and their expression patterns during thermal stress and pupal diapause in the corn earworm.

Zhang Q, Denlinger DL.

J Insect Physiol. 2010 Feb;56(2):138-50. doi: 10.1016/j.jinsphys.2009.09.013. Epub 2009 Oct 12.


Alterations of the Hsp70/Hsp90 chaperone and the HOP/CHIP co-chaperone system in cancer.

Ruckova E, Muller P, Nenutil R, Vojtesek B.

Cell Mol Biol Lett. 2012 Sep;17(3):446-58. doi: 10.2478/s11658-012-0021-8. Epub 2012 Jun 5.


HSP90 modulates actin dynamics: inhibition of HSP90 leads to decreased cell motility and impairs invasion.

Taiyab A, Rao ChM.

Biochim Biophys Acta. 2011 Jan;1813(1):213-21. doi: 10.1016/j.bbamcr.2010.09.012. Epub 2010 Sep 29.


HDAC6 inhibition enhances 17-AAG--mediated abrogation of hsp90 chaperone function in human leukemia cells.

Rao R, Fiskus W, Yang Y, Lee P, Joshi R, Fernandez P, Mandawat A, Atadja P, Bradner JE, Bhalla K.

Blood. 2008 Sep 1;112(5):1886-93. doi: 10.1182/blood-2008-03-143644. Epub 2008 Jun 30.


Importance of the C-terminal domain of Harc for binding to Hsp70 and Hop as well as its response to heat shock.

Cartledge K, Elsegood C, Roiniotis J, Hamilton JA, Scholz GM.

Biochemistry. 2007 Dec 25;46(51):15144-52. Epub 2007 Dec 1.


[Comparative study of expression levels of the major human heat shock proteins in cancer and normal tissues].

Shi Y, Zhao M, Xu X.

Zhonghua Zhong Liu Za Zhi. 1998 Jul;20(4):277-9. Chinese.


Withanolides-induced breast cancer cell death is correlated with their ability to inhibit heat protein 90.

Wang HC, Tsai YL, Wu YC, Chang FR, Liu MH, Chen WY, Wu CC.

PLoS One. 2012;7(5):e37764. doi: 10.1371/journal.pone.0037764. Epub 2012 May 31.


The PI3K/Akt signaling pathway regulates the expression of Hsp70, which critically contributes to Hsp90-chaperone function and tumor cell survival in multiple myeloma.

Chatterjee M, Andrulis M, Stühmer T, Müller E, Hofmann C, Steinbrunn T, Heimberger T, Schraud H, Kressmann S, Einsele H, Bargou RC.

Haematologica. 2013 Jul;98(7):1132-41. doi: 10.3324/haematol.2012.066175. Epub 2012 Oct 12.


Hsp105alpha suppresses Hsc70 chaperone activity by inhibiting Hsc70 ATPase activity.

Yamagishi N, Ishihara K, Hatayama T.

J Biol Chem. 2004 Oct 1;279(40):41727-33. Epub 2004 Aug 2.

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