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Items: 1 to 20 of 203


The missing step of the L-galactose pathway of ascorbate biosynthesis in plants, an L-galactose guanyltransferase, increases leaf ascorbate content.

Laing WA, Wright MA, Cooney J, Bulley SM.

Proc Natl Acad Sci U S A. 2007 May 29;104(22):9534-9. Epub 2007 May 7.


Gene expression studies in kiwifruit and gene over-expression in Arabidopsis indicates that GDP-L-galactose guanyltransferase is a major control point of vitamin C biosynthesis.

Bulley SM, Rassam M, Hoser D, Otto W, Sch√ľnemann N, Wright M, MacRae E, Gleave A, Laing W.

J Exp Bot. 2009;60(3):765-78. doi: 10.1093/jxb/ern327. Epub 2009 Jan 6.


A second GDP-L-galactose phosphorylase in arabidopsis en route to vitamin C. Covalent intermediate and substrate requirements for the conserved reaction.

Linster CL, Adler LN, Webb K, Christensen KC, Brenner C, Clarke SG.

J Biol Chem. 2008 Jul 4;283(27):18483-92. doi: 10.1074/jbc.M802594200. Epub 2008 May 7.


Two genes in Arabidopsis thaliana encoding GDP-L-galactose phosphorylase are required for ascorbate biosynthesis and seedling viability.

Dowdle J, Ishikawa T, Gatzek S, Rolinski S, Smirnoff N.

Plant J. 2007 Nov;52(4):673-89. Epub 2007 Sep 18. Erratum in: Plant J. 2008 Feb;53(3):595.


Arabidopsis thaliana VTC4 encodes L-galactose-1-P phosphatase, a plant ascorbic acid biosynthetic enzyme.

Conklin PL, Gatzek S, Wheeler GL, Dowdle J, Raymond MJ, Rolinski S, Isupov M, Littlechild JA, Smirnoff N.

J Biol Chem. 2006 Jun 9;281(23):15662-70. Epub 2006 Apr 4.


Enhancing ascorbate in fruits and tubers through over-expression of the L-galactose pathway gene GDP-L-galactose phosphorylase.

Bulley S, Wright M, Rommens C, Yan H, Rassam M, Lin-Wang K, Andre C, Brewster D, Karunairetnam S, Allan AC, Laing WA.

Plant Biotechnol J. 2012 May;10(4):390-7. doi: 10.1111/j.1467-7652.2011.00668.x. Epub 2011 Dec 1.


Genetic evidence for the role of GDP-mannose in plant ascorbic acid (vitamin C) biosynthesis.

Conklin PL, Norris SR, Wheeler GL, Williams EH, Smirnoff N, Last RL.

Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):4198-203.


Arabidopsis VTC2 encodes a GDP-L-galactose phosphorylase, the last unknown enzyme in the Smirnoff-Wheeler pathway to ascorbic acid in plants.

Linster CL, Gomez TA, Christensen KC, Adler LN, Young BD, Brenner C, Clarke SG.

J Biol Chem. 2007 Jun 29;282(26):18879-85. Epub 2007 Apr 26.


A highly specific L-galactose-1-phosphate phosphatase on the path to ascorbate biosynthesis.

Laing WA, Bulley S, Wright M, Cooney J, Jensen D, Barraclough D, MacRae E.

Proc Natl Acad Sci U S A. 2004 Nov 30;101(48):16976-81. Epub 2004 Nov 18.


The biosynthetic pathway of vitamin C in higher plants.

Wheeler GL, Jones MA, Smirnoff N.

Nature. 1998 May 28;393(6683):365-9.


Comparison of ascorbic acid biosynthesis in different tissues of three non-heading Chinese cabbage cultivars.

Ren J, Chen Z, Duan W, Song X, Liu T, Wang J, Hou X, Li Y.

Plant Physiol Biochem. 2013 Dec;73:229-36. doi: 10.1016/j.plaphy.2013.10.005. Epub 2013 Oct 10.


A bifunctional enzyme with L-fucokinase and GDP-L-fucose pyrophosphorylase activities salvages free L-fucose in Arabidopsis.

Kotake T, Hojo S, Tajima N, Matsuoka K, Koyama T, Tsumuraya Y.

J Biol Chem. 2008 Mar 28;283(13):8125-35. doi: 10.1074/jbc.M710078200. Epub 2008 Jan 16.


AMR1, an Arabidopsis gene that coordinately and negatively regulates the mannose/l-galactose ascorbic acid biosynthetic pathway.

Zhang W, Lorence A, Gruszewski HA, Chevone BI, Nessler CL.

Plant Physiol. 2009 Jun;150(2):942-50. doi: 10.1104/pp.109.138453. Epub 2009 Apr 24.


Increase in ascorbate content of transgenic tobacco plants overexpressing the acerola (Malpighia glabra) phosphomannomutase gene.

Badejo AA, Eltelib HA, Fukunaga K, Fujikawa Y, Esaka M.

Plant Cell Physiol. 2009 Feb;50(2):423-8. doi: 10.1093/pcp/pcn206. Epub 2009 Jan 2.


Light regulation of ascorbate biosynthesis is dependent on the photosynthetic electron transport chain but independent of sugars in Arabidopsis.

Yabuta Y, Mieda T, Rapolu M, Nakamura A, Motoki T, Maruta T, Yoshimura K, Ishikawa T, Shigeoka S.

J Exp Bot. 2007;58(10):2661-71. Epub 2007 Jun 22.

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