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Items: 1 to 20 of 437


Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+.

Belenky P, Racette FG, Bogan KL, McClure JM, Smith JS, Brenner C.

Cell. 2007 May 4;129(3):473-84.


Nicotinamide riboside and nicotinic acid riboside salvage in fungi and mammals. Quantitative basis for Urh1 and purine nucleoside phosphorylase function in NAD+ metabolism.

Belenky P, Christensen KC, Gazzaniga F, Pletnev AA, Brenner C.

J Biol Chem. 2009 Jan 2;284(1):158-64. doi: 10.1074/jbc.M807976200. Epub 2008 Nov 11. Erratum in: J Biol Chem. 2009 Mar 20;284(12):8208.


Vitamins and aging: pathways to NAD+ synthesis.

Denu JM.

Cell. 2007 May 4;129(3):453-4.


Chemical activation of Sir2-dependent silencing by relief of nicotinamide inhibition.

Sauve AA, Moir RD, Schramm VL, Willis IM.

Mol Cell. 2005 Feb 18;17(4):595-601.


Nicotinamide clearance by Pnc1 directly regulates Sir2-mediated silencing and longevity.

Gallo CM, Smith DL Jr, Smith JS.

Mol Cell Biol. 2004 Feb;24(3):1301-12.


Sirtuin-independent effects of nicotinamide on lifespan extension from calorie restriction in yeast.

Tsuchiya M, Dang N, Kerr EO, Hu D, Steffen KK, Oakes JA, Kennedy BK, Kaeberlein M.

Aging Cell. 2006 Dec;5(6):505-14.


Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae.

Anderson RM, Bitterman KJ, Wood JG, Medvedik O, Sinclair DA.

Nature. 2003 May 8;423(6936):181-5.


Pnc1p-mediated nicotinamide clearance modifies the epigenetic properties of rDNA silencing in Saccharomyces cerevisiae.

McClure JM, Gallo CM, Smith DL Jr, Matecic M, Hontz RD, Buck SW, Racette FG, Smith JS.

Genetics. 2008 Oct;180(2):797-810. doi: 10.1534/genetics.108.091090. Epub 2008 Sep 9.


Assimilation of NAD(+) precursors in Candida glabrata.

Ma B, Pan SJ, Zupancic ML, Cormack BP.

Mol Microbiol. 2007 Oct;66(1):14-25. Epub 2007 Aug 28.


Assimilation of endogenous nicotinamide riboside is essential for calorie restriction-mediated life span extension in Saccharomyces cerevisiae.

Lu SP, Kato M, Lin SJ.

J Biol Chem. 2009 Jun 19;284(25):17110-9. doi: 10.1074/jbc.M109.004010. Epub 2009 May 5.


Isonicotinamide enhances Sir2 protein-mediated silencing and longevity in yeast by raising intracellular NAD+ concentration.

McClure JM, Wierman MB, Maqani N, Smith JS.

J Biol Chem. 2012 Jun 15;287(25):20957-66. doi: 10.1074/jbc.M112.367524. Epub 2012 Apr 26.


Nicotinamide riboside kinase structures reveal new pathways to NAD+.

Tempel W, Rabeh WM, Bogan KL, Belenky P, Wojcik M, Seidle HF, Nedyalkova L, Yang T, Sauve AA, Park HW, Brenner C.

PLoS Biol. 2007 Oct 2;5(10):e263.


Saccharomyces cerevisiae YOR071C encodes the high affinity nicotinamide riboside transporter Nrt1.

Belenky PA, Moga TG, Brenner C.

J Biol Chem. 2008 Mar 28;283(13):8075-9. doi: 10.1074/jbc.C800021200. Epub 2008 Feb 6.


Longevity research. Single signal unites treatments that prolong life.

Strauss E.

Science. 2003 May 9;300(5621):881-3. No abstract available.


Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1.

Bitterman KJ, Anderson RM, Cohen HY, Latorre-Esteves M, Sinclair DA.

J Biol Chem. 2002 Nov 22;277(47):45099-107. Epub 2002 Sep 23.


Quantification of protein copy number in yeast: the NAD+ metabolome.

Mei SC, Brenner C.

PLoS One. 2014 Sep 4;9(9):e106496. doi: 10.1371/journal.pone.0106496. eCollection 2014.


Swapping the gene-specific and regional silencing specificities of the Hst1 and Sir2 histone deacetylases.

Mead J, McCord R, Youngster L, Sharma M, Gartenberg MR, Vershon AK.

Mol Cell Biol. 2007 Apr;27(7):2466-75. Epub 2007 Jan 22.

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