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Items: 1 to 20 of 256

1.

Role of glutamate decarboxylase (GAD) isoform, GAD65, in GABA synthesis and transport into synaptic vesicles-Evidence from GAD65-knockout mice studies.

Wu H, Jin Y, Buddhala C, Osterhaus G, Cohen E, Jin H, Wei J, Davis K, Obata K, Wu JY.

Brain Res. 2007 Jun 18;1154:80-3. Epub 2007 Apr 6.

PMID:
17482148
2.

A novel mechanism for GABA synthesis and packaging into synaptic vesicles.

Buddhala C, Hsu CC, Wu JY.

Neurochem Int. 2009 Jul-Aug;55(1-3):9-12. doi: 10.1016/j.neuint.2009.01.020. Epub 2009 Feb 6. Review.

PMID:
19428801
3.

Glutamate decarboxylase and GABA in pancreatic islets: lessons from knock-out mice.

Kash SF, Condie BG, Baekkeskov S.

Horm Metab Res. 1999 May;31(5):340-4.

PMID:
10422732
4.

Respiratory activity in brainstem of fetal mice lacking glutamate decarboxylase 65/67 and vesicular GABA transporter.

Fujii M, Arata A, Kanbara-Kume N, Saito K, Yanagawa Y, Obata K.

Neuroscience. 2007 May 25;146(3):1044-52. Epub 2007 Apr 5.

PMID:
17418495
5.

GABAergic dysfunction in mGlu7 receptor-deficient mice as reflected by decreased levels of glutamic acid decarboxylase 65 and 67kDa and increased reelin proteins in the hippocampus.

Wierońska JM, Brański P, Siwek A, Dybala M, Nowak G, Pilc A.

Brain Res. 2010 Jun 2;1334:12-24. doi: 10.1016/j.brainres.2010.03.078. Epub 2010 Mar 29.

PMID:
20353761
6.

GAD65 is essential for synthesis of GABA destined for tonic inhibition regulating epileptiform activity.

Walls AB, Nilsen LH, Eyjolfsson EM, Vestergaard HT, Hansen SL, Schousboe A, Sonnewald U, Waagepetersen HS.

J Neurochem. 2010 Dec;115(6):1398-408. doi: 10.1111/j.1471-4159.2010.07043.x. Epub 2010 Nov 4.

7.

Epilepsy in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase.

Kash SF, Johnson RS, Tecott LH, Noebels JL, Mayfield RD, Hanahan D, Baekkeskov S.

Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):14060-5.

8.

Demonstration of functional coupling between gamma -aminobutyric acid (GABA) synthesis and vesicular GABA transport into synaptic vesicles.

Jin H, Wu H, Osterhaus G, Wei J, Davis K, Sha D, Floor E, Hsu CC, Kopke RD, Wu JY.

Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4293-8. Epub 2003 Mar 12.

9.

GAD65/GAD67 double knockout mice exhibit intermediate severity in both cleft palate and omphalocele compared with GAD67 knockout and VGAT knockout mice.

Kakizaki T, Oriuchi N, Yanagawa Y.

Neuroscience. 2015 Mar 12;288:86-93. doi: 10.1016/j.neuroscience.2014.12.030. Epub 2014 Dec 26.

PMID:
25545713
10.

Regulation of GABA Neurotransmission by Glutamic Acid Decarboxylase (GAD).

Modi JP, Prentice H, Wu JY.

Curr Pharm Des. 2015;21(34):4939-42.

PMID:
26377650
11.

Mice lacking the 65 kDa isoform of glutamic acid decarboxylase (GAD65) maintain normal levels of GAD67 and GABA in their brains but are susceptible to seizures.

Asada H, Kawamura Y, Maruyama K, Kume H, Ding R, Ji FY, Kanbara N, Kuzume H, Sanbo M, Yagi T, Obata K.

Biochem Biophys Res Commun. 1996 Dec 24;229(3):891-5.

PMID:
8954991
12.

The role of the synthetic enzyme GAD65 in the control of neuronal gamma-aminobutyric acid release.

Tian N, Petersen C, Kash S, Baekkeskov S, Copenhagen D, Nicoll R.

Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12911-6.

13.

Knockout of GAD65 has major impact on synaptic GABA synthesized from astrocyte-derived glutamine.

Walls AB, Eyjolfsson EM, Smeland OB, Nilsen LH, Schousboe I, Schousboe A, Sonnewald U, Waagepetersen HS.

J Cereb Blood Flow Metab. 2011 Feb;31(2):494-503. doi: 10.1038/jcbfm.2010.115. Epub 2010 Jul 28.

14.
15.

Thermal hyperalgesia via supraspinal mechanisms in mice lacking glutamate decarboxylase 65.

Kubo K, Nishikawa K, Ishizeki J, Hardy-Yamada M, Yanagawa Y, Saito S.

J Pharmacol Exp Ther. 2009 Oct;331(1):162-9. doi: 10.1124/jpet.109.156034. Epub 2009 Jul 1.

17.

Postnatal development of a GABA deficit and disturbance of neural functions in mice lacking GAD65.

Stork O, Ji FY, Kaneko K, Stork S, Yoshinobu Y, Moriya T, Shibata S, Obata K.

Brain Res. 2000 May 19;865(1):45-58.

PMID:
10814732
18.

Two distinct mechanisms target GAD67 to vesicular pathways and presynaptic clusters.

Kanaani J, Kolibachuk J, Martinez H, Baekkeskov S.

J Cell Biol. 2010 Sep 6;190(5):911-25. doi: 10.1083/jcb.200912101. Epub 2010 Aug 30.

19.

Fluorescent labeling of both GABAergic and glycinergic neurons in vesicular GABA transporter (VGAT)-venus transgenic mouse.

Wang Y, Kakizaki T, Sakagami H, Saito K, Ebihara S, Kato M, Hirabayashi M, Saito Y, Furuya N, Yanagawa Y.

Neuroscience. 2009 Dec 15;164(3):1031-43. doi: 10.1016/j.neuroscience.2009.09.010. Epub 2009 Sep 17.

PMID:
19766173
20.

Altered responses to propofol, but not ketamine, in mice deficient in the 65-kilodalton isoform of glutamate decarboxylase.

Kubo K, Nishikawa K, Hardy-Yamada M, Ishizeki J, Yanagawa Y, Saito S.

J Pharmacol Exp Ther. 2009 May;329(2):592-9. doi: 10.1124/jpet.109.151456. Epub 2009 Feb 20.

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