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Results: 1 to 20 of 111

1.

Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model.

Roberson ED, Scearce-Levie K, Palop JJ, Yan F, Cheng IH, Wu T, Gerstein H, Yu GQ, Mucke L.

Science. 2007 May 4;316(5825):750-4.

PMID:
17478722
[PubMed - indexed for MEDLINE]
Free Article
2.

FLZ alleviates the memory deficits in transgenic mouse model of Alzheimer's disease via decreasing beta-amyloid production and tau hyperphosphorylation.

Bao XQ, Li N, Wang T, Kong XC, Tai WJ, Sun H, Zhang D.

PLoS One. 2013 Nov 4;8(11):e78033. doi: 10.1371/journal.pone.0078033. eCollection 2013.

PMID:
24223757
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Amyloid-β/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease.

Roberson ED, Halabisky B, Yoo JW, Yao J, Chin J, Yan F, Wu T, Hamto P, Devidze N, Yu GQ, Palop JJ, Noebels JL, Mucke L.

J Neurosci. 2011 Jan 12;31(2):700-11. doi: 10.1523/JNEUROSCI.4152-10.2011.

PMID:
21228179
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Chronic mild sleep restriction accentuates contextual memory impairments, and accumulations of cortical Aβ and pTau in a mouse model of Alzheimer's disease.

Rothman SM, Herdener N, Frankola KA, Mughal MR, Mattson MP.

Brain Res. 2013 Sep 5;1529:200-8. doi: 10.1016/j.brainres.2013.07.010. Epub 2013 Jul 13.

PMID:
23856323
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

L-3-n-butylphthalide reduces tau phosphorylation and improves cognitive deficits in AβPP/PS1-Alzheimer's transgenic mice.

Peng Y, Hu Y, Xu S, Li P, Li J, Lu L, Yang H, Feng N, Wang L, Wang X.

J Alzheimers Dis. 2012;29(2):379-91. doi: 10.3233/JAD-2011-111577.

PMID:
22233765
[PubMed - indexed for MEDLINE]
6.

A novel glycogen synthase kinase-3 inhibitor 2-methyl-5-(3-{4-[(S )-methylsulfinyl]phenyl}-1-benzofuran-5-yl)-1,3,4-oxadiazole decreases tau phosphorylation and ameliorates cognitive deficits in a transgenic model of Alzheimer's disease.

Onishi T, Iwashita H, Uno Y, Kunitomo J, Saitoh M, Kimura E, Fujita H, Uchiyama N, Kori M, Takizawa M.

J Neurochem. 2011 Dec;119(6):1330-40. doi: 10.1111/j.1471-4159.2011.07532.x. Epub 2011 Nov 2.

PMID:
21992552
[PubMed - indexed for MEDLINE]
7.

L-3-n-butylphthalide improves cognitive impairment and reduces amyloid-beta in a transgenic model of Alzheimer's disease.

Peng Y, Sun J, Hon S, Nylander AN, Xia W, Feng Y, Wang X, Lemere CA.

J Neurosci. 2010 Jun 16;30(24):8180-9. doi: 10.1523/JNEUROSCI.0340-10.2010.

PMID:
20554868
[PubMed - indexed for MEDLINE]
Free Article
8.

CBP gene transfer increases BDNF levels and ameliorates learning and memory deficits in a mouse model of Alzheimer's disease.

Caccamo A, Maldonado MA, Bokov AF, Majumder S, Oddo S.

Proc Natl Acad Sci U S A. 2010 Dec 28;107(52):22687-92. doi: 10.1073/pnas.1012851108. Epub 2010 Dec 13.

PMID:
21149712
[PubMed - indexed for MEDLINE]
Free PMC Article
9.
10.

Amyloid reduction by amyloid-beta vaccination also reduces mouse tau pathology and protects from neuron loss in two mouse models of Alzheimer's disease.

Wilcock DM, Gharkholonarehe N, Van Nostrand WE, Davis J, Vitek MP, Colton CA.

J Neurosci. 2009 Jun 24;29(25):7957-65. doi: 10.1523/JNEUROSCI.1339-09.2009. Erratum in: J Neurosci. 2010 Jan 20;30(3):1197-8.

PMID:
19553436
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Propranolol reduces cognitive deficits, amyloid and tau pathology in Alzheimer's transgenic mice.

Dobarro M, Gerenu G, Ramírez MJ.

Int J Neuropsychopharmacol. 2013 Nov;16(10):2245-57. doi: 10.1017/S1461145713000631. Epub 2013 Jun 17.

PMID:
23768694
[PubMed - indexed for MEDLINE]
12.

PGC-1α overexpression exacerbates β-amyloid and tau deposition in a transgenic mouse model of Alzheimer's disease.

Dumont M, Stack C, Elipenahli C, Jainuddin S, Launay N, Gerges M, Starkova N, Starkov AA, Calingasan NY, Tampellini D, Pujol A, Beal MF.

FASEB J. 2014 Apr;28(4):1745-55. doi: 10.1096/fj.13-236331. Epub 2014 Jan 7.

PMID:
24398293
[PubMed - indexed for MEDLINE]
13.

Partial reduction of BACE1 improves synaptic plasticity, recent and remote memories in Alzheimer's disease transgenic mice.

Kimura R, Devi L, Ohno M.

J Neurochem. 2010 Apr;113(1):248-61. doi: 10.1111/j.1471-4159.2010.06608.x. Epub 2010 Jan 20.

PMID:
20089133
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Early intervention in the 3xTg-AD mice with an amyloid β-antibody fragment ameliorates first hallmarks of Alzheimer disease.

Giménez-Llort L, Rivera-Hernández G, Marin-Argany M, Sánchez-Quesada JL, Villegas S.

MAbs. 2013 Sep-Oct;5(5):665-77. doi: 10.4161/mabs.25424. Epub 2013 Jun 20.

PMID:
23884018
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β.

Nussbaum JM, Schilling S, Cynis H, Silva A, Swanson E, Wangsanut T, Tayler K, Wiltgen B, Hatami A, Rönicke R, Reymann K, Hutter-Paier B, Alexandru A, Jagla W, Graubner S, Glabe CG, Demuth HU, Bloom GS.

Nature. 2012 May 2;485(7400):651-5. doi: 10.1038/nature11060.

PMID:
22660329
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease.

Sanchez-Mejia RO, Newman JW, Toh S, Yu GQ, Zhou Y, Halabisky B, Cissé M, Scearce-Levie K, Cheng IH, Gan L, Palop JJ, Bonventre JV, Mucke L.

Nat Neurosci. 2008 Nov;11(11):1311-8. doi: 10.1038/nn.2213. Epub 2008 Oct 19.

PMID:
18931664
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Soluble Aβ levels correlate with cognitive deficits in the 12-month-old APPswe/PS1dE9 mouse model of Alzheimer's disease.

Zhang W, Hao J, Liu R, Zhang Z, Lei G, Su C, Miao J, Li Z.

Behav Brain Res. 2011 Sep 23;222(2):342-50. doi: 10.1016/j.bbr.2011.03.072. Epub 2011 Apr 14.

PMID:
21513747
[PubMed - indexed for MEDLINE]
18.

Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer's disease.

Manczak M, Reddy PH.

Hum Mol Genet. 2012 Dec 1;21(23):5131-46. doi: 10.1093/hmg/dds360. Epub 2012 Aug 27.

PMID:
22926141
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Synergistic Interactions between Abeta, tau, and alpha-synuclein: acceleration of neuropathology and cognitive decline.

Clinton LK, Blurton-Jones M, Myczek K, Trojanowski JQ, LaFerla FM.

J Neurosci. 2010 May 26;30(21):7281-9. doi: 10.1523/JNEUROSCI.0490-10.2010.

PMID:
20505094
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Mifepristone alters amyloid precursor protein processing to preclude amyloid beta and also reduces tau pathology.

Baglietto-Vargas D, Medeiros R, Martinez-Coria H, LaFerla FM, Green KN.

Biol Psychiatry. 2013 Sep 1;74(5):357-66. doi: 10.1016/j.biopsych.2012.12.003. Epub 2013 Jan 8.

PMID:
23312564
[PubMed - indexed for MEDLINE]
Free PMC Article

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