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Items: 1 to 20 of 110

1.

Akt blocks ligand binding and protects against expanded polyglutamine androgen receptor toxicity.

Palazzolo I, Burnett BG, Young JE, Brenne PL, La Spada AR, Fischbeck KH, Howell BW, Pennuto M.

Hum Mol Genet. 2007 Jul 1;16(13):1593-603. Epub 2007 Apr 30.

2.

Overexpression of IGF-1 in muscle attenuates disease in a mouse model of spinal and bulbar muscular atrophy.

Palazzolo I, Stack C, Kong L, Musaro A, Adachi H, Katsuno M, Sobue G, Taylor JP, Sumner CJ, Fischbeck KH, Pennuto M.

Neuron. 2009 Aug 13;63(3):316-28. doi: 10.1016/j.neuron.2009.07.019.

3.

Protein arginine methyltransferase 6 enhances polyglutamine-expanded androgen receptor function and toxicity in spinal and bulbar muscular atrophy.

Scaramuzzino C, Casci I, Parodi S, Lievens PM, Polanco MJ, Milioto C, Chivet M, Monaghan J, Mishra A, Badders N, Aggarwal T, Grunseich C, Sambataro F, Basso M, Fackelmayer FO, Taylor JP, Pandey UB, Pennuto M.

Neuron. 2015 Jan 7;85(1):88-100. doi: 10.1016/j.neuron.2014.12.031.

4.

Cytoplasmic retention of polyglutamine-expanded androgen receptor ameliorates disease via autophagy in a mouse model of spinal and bulbar muscular atrophy.

Montie HL, Cho MS, Holder L, Liu Y, Tsvetkov AS, Finkbeiner S, Merry DE.

Hum Mol Genet. 2009 Jun 1;18(11):1937-50. doi: 10.1093/hmg/ddp115. Epub 2009 Mar 11.

5.

Pathogenesis and therapy of spinal and bulbar muscular atrophy (SBMA).

Katsuno M, Tanaka F, Adachi H, Banno H, Suzuki K, Watanabe H, Sobue G.

Prog Neurobiol. 2012 Dec;99(3):246-56. doi: 10.1016/j.pneurobio.2012.05.007. Epub 2012 May 15. Review.

PMID:
22609045
6.

Spinal and bulbar muscular atrophy: ligand-dependent pathogenesis and therapeutic perspectives.

Katsuno M, Adachi H, Tanaka F, Sobue G.

J Mol Med (Berl). 2004 May;82(5):298-307. Epub 2004 Feb 27. Review.

PMID:
15133611
7.

Antiandrogen flutamide protects male mice from androgen-dependent toxicity in three models of spinal bulbar muscular atrophy.

Renier KJ, Troxell-Smith SM, Johansen JA, Katsuno M, Adachi H, Sobue G, Chua JP, Sun Kim H, Lieberman AP, Breedlove SM, Jordan CL.

Endocrinology. 2014 Jul;155(7):2624-34. doi: 10.1210/en.2013-1756. Epub 2014 Apr 17.

8.

B2 attenuates polyglutamine-expanded androgen receptor toxicity in cell and fly models of spinal and bulbar muscular atrophy.

Palazzolo I, Nedelsky NB, Askew CE, Harmison GG, Kasantsev AG, Taylor JP, Fischbeck KH, Pennuto M.

J Neurosci Res. 2010 Aug 1;88(10):2207-16. doi: 10.1002/jnr.22389.

9.
10.

[Triplet repeat disease, with particular emphasis of spinal and bulbar muscular atrophy (SBMA)].

Sobue G.

Rinsho Shinkeigaku. 2000 Dec;40(12):1193-5. Japanese.

PMID:
11464455
11.

Hsp105alpha suppresses the aggregation of truncated androgen receptor with expanded CAG repeats and cell toxicity.

Ishihara K, Yamagishi N, Saito Y, Adachi H, Kobayashi Y, Sobue G, Ohtsuka K, Hatayama T.

J Biol Chem. 2003 Jul 4;278(27):25143-50. Epub 2003 Apr 24.

12.

Caspase-3 cleaves the expanded androgen receptor protein of spinal and bulbar muscular atrophy in a polyglutamine repeat length-dependent manner.

Kobayashi Y, Miwa S, Merry DE, Kume A, Mei L, Doyu M, Sobue G.

Biochem Biophys Res Commun. 1998 Nov 9;252(1):145-50.

PMID:
9813160
13.

Cell biological approaches to investigate polyglutamine-expanded AR metabolism.

Cooper LJ, Merry DE.

Methods Mol Biol. 2013;1017:241-53. doi: 10.1007/978-1-62703-438-8_18.

PMID:
23719921
14.
15.

Aberrant E2F activation by polyglutamine expansion of androgen receptor in SBMA neurotoxicity.

Suzuki E, Zhao Y, Ito S, Sawatsubashi S, Murata T, Furutani T, Shirode Y, Yamagata K, Tanabe M, Kimura S, Ueda T, Fujiyama S, Lim J, Matsukawa H, Kouzmenko AP, Aigaki T, Tabata T, Takeyama K, Kato S.

Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3818-22. doi: 10.1073/pnas.0809819106. Epub 2009 Feb 23. Erratum in: Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16393.

16.

An interdomain interaction of the androgen receptor is required for its aggregation and toxicity in spinal and bulbar muscular atrophy.

Orr CR, Montie HL, Liu Y, Bolzoni E, Jenkins SC, Wilson EM, Joseph JD, McDonnell DP, Merry DE.

J Biol Chem. 2010 Nov 12;285(46):35567-77. doi: 10.1074/jbc.M110.146845. Epub 2010 Sep 8.

17.

Polyglutamine-expanded androgen receptor truncation fragments activate a Bax-dependent apoptotic cascade mediated by DP5/Hrk.

Young JE, Garden GA, Martinez RA, Tanaka F, Sandoval CM, Smith AC, Sopher BL, Lin A, Fischbeck KH, Ellerby LM, Morrison RS, Taylor JP, La Spada AR.

J Neurosci. 2009 Feb 18;29(7):1987-97. doi: 10.1523/JNEUROSCI.4072-08.2009.

18.

Small ubiquitin-like modifier (SUMO) modification of the androgen receptor attenuates polyglutamine-mediated aggregation.

Mukherjee S, Thomas M, Dadgar N, Lieberman AP, Iñiguez-Lluhí JA.

J Biol Chem. 2009 Aug 7;284(32):21296-306. doi: 10.1074/jbc.M109.011494. Epub 2009 Jun 4.

19.

SIRT1 modulates aggregation and toxicity through deacetylation of the androgen receptor in cell models of SBMA.

Montie HL, Pestell RG, Merry DE.

J Neurosci. 2011 Nov 30;31(48):17425-36. doi: 10.1523/JNEUROSCI.3958-11.2011.

20.

Insulinlike growth factor (IGF)-1 administration ameliorates disease manifestations in a mouse model of spinal and bulbar muscular atrophy.

Rinaldi C, Bott LC, Chen KL, Harmison GG, Katsuno M, Sobue G, Pennuto M, Fischbeck KH.

Mol Med. 2012 Dec 6;18:1261-8. doi: 10.2119/molmed.2012.00271.

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