Display Settings:

Format
Items per page
Sort by

Send to:

Choose Destination

Results: 1 to 20 of 172

1.

Characterization and optimization of selective, nonpeptidic inhibitors of cathepsin S with an unprecedented binding mode.

Inagaki H, Tsuruoka H, Hornsby M, Lesley SA, Spraggon G, Ellman JA.

J Med Chem. 2007 May 31;50(11):2693-9. Epub 2007 May 1.

PMID:
17469812
[PubMed - indexed for MEDLINE]
2.

Identification of selective, nonpeptidic nitrile inhibitors of cathepsin s using the substrate activity screening method.

Patterson AW, Wood WJ, Hornsby M, Lesley S, Spraggon G, Ellman JA.

J Med Chem. 2006 Oct 19;49(21):6298-307.

PMID:
17034136
[PubMed - indexed for MEDLINE]
3.

The consequences of lysosomotropism on the design of selective cathepsin K inhibitors.

Black WC, Percival MD.

Chembiochem. 2006 Oct;7(10):1525-35. Review.

PMID:
16921579
[PubMed - indexed for MEDLINE]
4.

Exploring inhibitor binding at the S' subsites of cathepsin L.

Chowdhury SF, Joseph L, Kumar S, Tulsidas SR, Bhat S, Ziomek E, Ménard R, Sivaraman J, Purisima EO.

J Med Chem. 2008 Mar 13;51(5):1361-8. doi: 10.1021/jm701190v. Epub 2008 Feb 16.

PMID:
18278855
[PubMed - indexed for MEDLINE]
5.

A novel class of nonpeptidic biaryl inhibitors of human cathepsin K.

Robichaud J, Oballa R, Prasit P, Falgueyret JP, Percival MD, Wesolowski G, Rodan SB, Kimmel D, Johnson C, Bryant C, Venkatraman S, Setti E, Mendonca R, Palmer JT.

J Med Chem. 2003 Aug 14;46(17):3709-27.

PMID:
12904076
[PubMed - indexed for MEDLINE]
6.

Design of noncovalent inhibitors of human cathepsin L. From the 96-residue proregion to optimized tripeptides.

Chowdhury SF, Sivaraman J, Wang J, Devanathan G, Lachance P, Qi H, Ménard R, Lefebvre J, Konishi Y, Cygler M, Sulea T, Purisima EO.

J Med Chem. 2002 Nov 21;45(24):5321-9.

PMID:
12431059
[PubMed - indexed for MEDLINE]
7.

Substrate activity screening: a fragment-based method for the rapid identification of nonpeptidic protease inhibitors.

Wood WJ, Patterson AW, Tsuruoka H, Jain RK, Ellman JA.

J Am Chem Soc. 2005 Nov 9;127(44):15521-7.

PMID:
16262416
[PubMed - indexed for MEDLINE]
8.

Beta-substituted cyclohexanecarboxamide: a nonpeptidic framework for the design of potent inhibitors of cathepsin K.

Crane SN, Black WC, Palmer JT, Davis DE, Setti E, Robichaud J, Paquet J, Oballa RM, Bayly CI, McKay DJ, Somoza JR, Chauret N, Seto C, Scheigetz J, Wesolowski G, Massé F, Desmarais S, Ouellet M.

J Med Chem. 2006 Feb 9;49(3):1066-79.

PMID:
16451072
[PubMed - indexed for MEDLINE]
9.

Azepanone-based inhibitors of human cathepsin L.

Marquis RW, James I, Zeng J, Trout RE, Thompson S, Rahman A, Yamashita DS, Xie R, Ru Y, Gress CJ, Blake S, Lark MA, Hwang SM, Tomaszek T, Offen P, Head MS, Cummings MD, Veber DF.

J Med Chem. 2005 Nov 3;48(22):6870-8.

PMID:
16250645
[PubMed - indexed for MEDLINE]
10.

Design of potent, selective, and orally bioavailable inhibitors of cysteine protease cathepsin k.

Tavares FX, Boncek V, Deaton DN, Hassell AM, Long ST, Miller AB, Payne AA, Miller LR, Shewchuk LM, Wells-Knecht K, Willard DH Jr, Wright LL, Zhou HQ.

J Med Chem. 2004 Jan 29;47(3):588-99.

PMID:
14736240
[PubMed - indexed for MEDLINE]
11.

Discovery of selective and nonpeptidic cathepsin S inhibitors.

Irie O, Ehara T, Iwasaki A, Yokokawa F, Sakaki J, Hirao H, Kanazawa T, Teno N, Horiuchi M, Umemura I, Gunji H, Masuya K, Hitomi Y, Iwasaki G, Nonomura K, Tanabe K, Fukaya H, Kosaka T, Snell CR, Hallett A.

Bioorg Med Chem Lett. 2008 Jul 15;18(14):3959-62. doi: 10.1016/j.bmcl.2008.06.009. Epub 2008 Jun 10.

PMID:
18572405
[PubMed - indexed for MEDLINE]
12.

Novel, potent P2-P3 pyrrolidine derivatives of ketoamide-based cathepsin K inhibitors.

Barrett DG, Catalano JG, Deaton DN, Hassell AM, Long ST, Miller AB, Miller LR, Ray JA, Samano V, Shewchuk LM, Wells-Knecht KJ, Willard DH Jr, Wright LL.

Bioorg Med Chem Lett. 2006 Mar 15;16(6):1735-9. Epub 2006 Jan 11.

PMID:
16376075
[PubMed - indexed for MEDLINE]
13.

Azepanone-based inhibitors of human and rat cathepsin K.

Marquis RW, Ru Y, LoCastro SM, Zeng J, Yamashita DS, Oh HJ, Erhard KF, Davis LD, Tomaszek TA, Tew D, Salyers K, Proksch J, Ward K, Smith B, Levy M, Cummings MD, Haltiwanger RC, Trescher G, Wang B, Hemling ME, Quinn CJ, Cheng HY, Lin F, Smith WW, Janson CA, Zhao B, McQueney MS, D'Alessio K, Lee CP, Marzulli A, Dodds RA, Blake S, Hwang SM, James IE, Gress CJ, Bradley BR, Lark MW, Gowen M, Veber DF.

J Med Chem. 2001 Apr 26;44(9):1380-95.

PMID:
11311061
[PubMed - indexed for MEDLINE]
14.

Novel purine nitrile derived inhibitors of the cysteine protease cathepsin K.

Altmann E, Cowan-Jacob SW, Missbach M.

J Med Chem. 2004 Nov 18;47(24):5833-6.

PMID:
15537340
[PubMed - indexed for MEDLINE]
15.

Acyclic cyanamide-based inhibitors of cathepsin K.

Barrett DG, Deaton DN, Hassell AM, McFadyen RB, Miller AB, Miller LR, Payne JA, Shewchuk LM, Willard DH Jr, Wright LL.

Bioorg Med Chem Lett. 2005 Jun 15;15(12):3039-43.

PMID:
15896958
[PubMed - indexed for MEDLINE]
16.

Discovery and SAR of novel pyrazole-based thioethers as cathepsin S inhibitors: part 1.

Lee-Dutra A, Wiener DK, Arienti KL, Liu J, Mani N, Ameriks MK, Axe FU, Gebauer D, Desai PJ, Nguyen S, Randal M, Thurmond RL, Sun S, Karlsson L, Edwards JP, Jones TK, Grice CA.

Bioorg Med Chem Lett. 2010 Apr 1;20(7):2370-4. doi: 10.1016/j.bmcl.2010.01.108. Epub 2010 Jan 28.

PMID:
20153648
[PubMed - indexed for MEDLINE]
17.

Structure-based design of cathepsin K inhibitors containing a benzyloxy-substituted benzoyl peptidomimetic.

Thompson SK, Smith WW, Zhao B, Halbert SM, Tomaszek TA, Tew DG, Levy MA, Janson CA, DAlessio KJ, McQueney MS, Kurdyla J, Jones CS, DesJarlais RL, Abdel-Meguid SS, Veber DF.

J Med Chem. 1998 Oct 8;41(21):3923-7.

PMID:
9767629
[PubMed - indexed for MEDLINE]
18.

2-Cyano-pyrimidines: a new chemotype for inhibitors of the cysteine protease cathepsin K.

Altmann E, Aichholz R, Betschart C, Buhl T, Green J, Irie O, Teno N, Lattmann R, Tintelnot-Blomley M, Missbach M.

J Med Chem. 2007 Feb 22;50(4):591-4. Epub 2007 Jan 27.

PMID:
17256925
[PubMed - indexed for MEDLINE]
19.

Crystal structure of human cathepsin S.

McGrath ME, Palmer JT, Brömme D, Somoza JR.

Protein Sci. 1998 Jun;7(6):1294-302.

PMID:
9655332
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Design and synthesis of arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Part 1.

Liu H, Tully DC, Epple R, Bursulaya B, Li J, Harris JL, Williams JA, Russo R, Tumanut C, Roberts MJ, Alper PB, He Y, Karanewsky DS.

Bioorg Med Chem Lett. 2005 Nov 15;15(22):4979-84. Epub 2005 Sep 23.

PMID:
16183279
[PubMed - indexed for MEDLINE]

Display Settings:

Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

Write to the Help Desk