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Results: 1 to 20 of 109

1.

Nkx2.2 regulates beta-cell function in the mature islet.

Doyle MJ, Sussel L.

Diabetes. 2007 Aug;56(8):1999-2007. Epub 2007 Apr 24.

PMID:
17456846
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Nkx2.2-repressor activity is sufficient to specify alpha-cells and a small number of beta-cells in the pancreatic islet.

Doyle MJ, Loomis ZL, Sussel L.

Development. 2007 Feb;134(3):515-23. Epub 2007 Jan 3.

PMID:
17202186
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Persistent expression of HNF6 in islet endocrine cells causes disrupted islet architecture and loss of beta cell function.

Gannon M, Ray MK, Van Zee K, Rausa F, Costa RH, Wright CV.

Development. 2000 Jul;127(13):2883-95.

PMID:
10851133
[PubMed - indexed for MEDLINE]
Free Article
4.

Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3.

Anderson KR, Torres CA, Solomon K, Becker TC, Newgard CB, Wright CV, Hagman J, Sussel L.

J Biol Chem. 2009 Nov 6;284(45):31236-48. doi: 10.1074/jbc.M109.048694. Epub 2009 Sep 15.

PMID:
19759004
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Pancreatic transcription factors containing protein transduction domains drive mouse embryonic stem cells towards endocrine pancreas.

Lima MJ, Docherty HM, Chen Y, Vallier L, Docherty K.

PLoS One. 2012;7(5):e36481. doi: 10.1371/journal.pone.0036481. Epub 2012 May 1.

PMID:
22563503
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Nkx2.2 activates the ghrelin promoter in pancreatic islet cells.

Hill JT, Chao CS, Anderson KR, Kaufman F, Johnson CW, Sussel L.

Mol Endocrinol. 2010 Feb;24(2):381-90. doi: 10.1210/me.2009-0360. Epub 2009 Dec 4.

PMID:
19965928
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells.

Sussel L, Kalamaras J, Hartigan-O'Connor DJ, Meneses JJ, Pedersen RA, Rubenstein JL, German MS.

Development. 1998 Jun;125(12):2213-21.

PMID:
9584121
[PubMed - indexed for MEDLINE]
Free Article
8.

Members of the large Maf transcription family regulate insulin gene transcription in islet beta cells.

Matsuoka TA, Zhao L, Artner I, Jarrett HW, Friedman D, Means A, Stein R.

Mol Cell Biol. 2003 Sep;23(17):6049-62.

PMID:
12917329
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Islet-enriched gene expression and glucose-induced insulin secretion in human and mouse islets.

Dai C, Brissova M, Hang Y, Thompson C, Poffenberger G, Shostak A, Chen Z, Stein R, Powers AC.

Diabetologia. 2012 Mar;55(3):707-18. doi: 10.1007/s00125-011-2369-0. Epub 2011 Dec 14.

PMID:
22167125
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

NeuroD1 in the endocrine pancreas: localization and dual function as an activator and repressor.

Itkin-Ansari P, Marcora E, Geron I, Tyrberg B, Demeterco C, Hao E, Padilla C, Ratineau C, Leiter A, Lee JE, Levine F.

Dev Dyn. 2005 Jul;233(3):946-53.

PMID:
15906379
[PubMed - indexed for MEDLINE]
Free Article
11.

Islet-1 is required for the maturation, proliferation, and survival of the endocrine pancreas.

Du A, Hunter CS, Murray J, Noble D, Cai CL, Evans SM, Stein R, May CL.

Diabetes. 2009 Sep;58(9):2059-69. doi: 10.2337/db08-0987. Epub 2009 Jun 5.

PMID:
19502415
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site.

Raum JC, Gerrish K, Artner I, Henderson E, Guo M, Sussel L, Schisler JC, Newgard CB, Stein R.

Mol Cell Biol. 2006 Aug;26(15):5735-43.

PMID:
16847327
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Profound defects in pancreatic beta-cell function in mice with combined heterozygous mutations in Pdx-1, Hnf-1alpha, and Hnf-3beta.

Shih DQ, Heimesaat M, Kuwajima S, Stein R, Wright CV, Stoffel M.

Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3818-23.

PMID:
11904435
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

In vivo conditional Pax4 overexpression in mature islet β-cells prevents stress-induced hyperglycemia in mice.

Hu He KH, Lorenzo PI, Brun T, Jimenez Moreno CM, Aeberhard D, Vallejo Ortega J, Cornu M, Thorel F, Gjinovci A, Thorens B, Herrera PL, Meda P, Wollheim CB, Gauthier BR.

Diabetes. 2011 Jun;60(6):1705-15. doi: 10.2337/db10-1102. Epub 2011 Apr 26.

PMID:
21521872
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Conditional expression of Smad7 in pancreatic beta cells disrupts TGF-beta signaling and induces reversible diabetes mellitus.

Smart NG, Apelqvist AA, Gu X, Harmon EB, Topper JN, MacDonald RJ, Kim SK.

PLoS Biol. 2006 Feb;4(2):e39. Epub 2006 Jan 31.

PMID:
16435884
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Nkx2.2 repressor complex regulates islet β-cell specification and prevents β-to-α-cell reprogramming.

Papizan JB, Singer RA, Tschen SI, Dhawan S, Friel JM, Hipkens SB, Magnuson MA, Bhushan A, Sussel L.

Genes Dev. 2011 Nov 1;25(21):2291-305. doi: 10.1101/gad.173039.111.

PMID:
22056672
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Maintenance of hepatic nuclear factor 6 in postnatal islets impairs terminal differentiation and function of beta-cells.

Tweedie E, Artner I, Crawford L, Poffenberger G, Thorens B, Stein R, Powers AC, Gannon M.

Diabetes. 2006 Dec;55(12):3264-70.

PMID:
17130469
[PubMed - indexed for MEDLINE]
Free Article
18.

Genetic identification of a novel NeuroD1 function in the early differentiation of islet alpha, PP and epsilon cells.

Chao CS, Loomis ZL, Lee JE, Sussel L.

Dev Biol. 2007 Dec 15;312(2):523-32. Epub 2007 Oct 5.

PMID:
17988662
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

PDX1 in ducts is not required for postnatal formation of β-cells but is necessary for their subsequent maturation.

Guo L, Inada A, Aguayo-Mazzucato C, Hollister-Lock J, Fujitani Y, Weir GC, Wright CV, Sharma A, Bonner-Weir S.

Diabetes. 2013 Oct;62(10):3459-68. doi: 10.2337/db12-1833. Epub 2013 Jun 17.

PMID:
23775765
[PubMed - indexed for MEDLINE]
Free Article
20.

Insulin secretory defects and impaired islet architecture in pancreatic beta-cell-specific STAT3 knockout mice.

Gorogawa S, Fujitani Y, Kaneto H, Hazama Y, Watada H, Miyamoto Y, Takeda K, Akira S, Magnuson MA, Yamasaki Y, Kajimoto Y, Hori M.

Biochem Biophys Res Commun. 2004 Jul 9;319(4):1159-70.

PMID:
15194489
[PubMed - indexed for MEDLINE]

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