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17434327,18591913,22387424,9126190,20728373,8679228,23850708,21193041,16456445,11751189,21035441,20075264,19071231,8758268,18369574,16409721,10704089,15967733,12097404,21272678,11309243,9070611,16445696,15351300,9700137,29461970,18791499,9563715,21872644,12005207,18328478,22921747,32403267,12126560,18059137,20510343,12947335,23751215,16920168,24681039,22564908,21542970,23302986,20074667,15970097,24571867,16936090,16135969,18535257,10806166,18082029,23651796,21767135,17785997,24380286,15168012,8110470,25818695,16574162,10392760,12437112,26196844,22952743,22683864,17430259,22377793,26147379,16514111,17889310,19121406,11525779,27735022,31295064,8624250,7489793,15318102,19572173,25038318,29098546,14703465,29350567,28008677,10799283,9011586,11273798,24681349,24792475,18983890,12882446,17965584,16871629,12850123,22836635,12462565,26707569,22610350,7943346,20080200,18442782,10027094,25218162,16829147,8741005,33214336,7952560,15996189,28039487,26648661,11739527,31579973,10419836,20238140,11226100,17557801,11300380,36591265,1825745,8728019,29684352,17458645,26853745,14504727,17171556,29248584,27411461,2024703,9401777,27992235,30188745,9683557,25563207,25428340,33131513,15965713,12901631,12005259,15962709,25947958,9778491,19526759,18457362,28585140,9840647,11403210,11923614,28807204,24299917,16481206,28542361,27183596,10545284,20466438,14722184,11091282,9202956,16681036,26088862,20349038,16215387,25115497,30466430,8564522,26551413,9212745,10063921,32035219,17552162,27504958,12028805,21504754,19225056,33471617,8575077,11342662,8166290,25466265,19010292,25358398,25327896,28438557,14586044,15968385,26255139,10727753,18306010,23160029,10442524,14502367,10522805,16196302,25828826,11093977,31113409,2124522,26303011,24153432,11053036,28082531,11360543,12397365,20830289,17242094,26368666,27676418,15526755,26209141,20073557,11810532,17467318,28531802,10850856,8946652,17883944,25962383,8079820,22546484,14555589,8543374,11167999,22975080,29545181,19039966,8897903,14729510,30841455,10704946,12832678,15297001,18991101,26283591,27498004,28088642,10822053,16261466,26679821,32744055,24417187,27916460,2668425,12879338,14633514,20851419,25791017,8114339,17352829,24747095,19662365,18421573,26647918,32643759,28871508,32231178,29731490,15136298,23383221,8298813,9632909,29123381,8975872,7825185,16472171,8751605,9415040,18023806,20938712,12766650,16645448,27181513,20009665,26992678,15761213,19175577,28936850,27721162,17467319,26740765,20726984,24456641,16086061,10715626,15697179,33024204,18774390,20729385,2644368,9429907,25878373,25234616,26388579,21679722,32005196,32267288,25649890,8843791,7775652,10593334,14739012,24187873,36993977,27266360,31928043,8574827,31685765,26513310,27939824,26545873,27352385,27546994,29719375,30466423,27622544,8369979,29180183,18492738,24143359,35066912,26040494,9503788,19110075,7515590,12372980,30651808,25864801,3397176,8638738,28028637,34587166,18601748,17086464,30291490,16892145,12462569,19529910,19292976,12819058,1949591,28486961,15489643,33880053,28177269,36757290,8969268,7595189,23156084,11199314,7747816,35212163,9698933,28205623,15778246,31502356,11961339,25729281,32640895,27330681,17015742,1894366,10596699,15683852,28797776,23179741,35358610,33073254,10771128,31001980,28574842,33203891,6435308,2735224,27956075,26244029,8933213,30305828,8162754,28099388,2648095,2145103,29847180,17640343,12765431,30684253,2758517,33831580,34017249,17378527,36076574,26598916,9088876,26392398,17400207,23025351,1402080,27265821,33068598,2606851,29145462,31921607,10682384,18302052,12704018,33812014,9029220,23226760,35882779,20596266,7776855,35679477,23791744,20547173,19842846,25006447,30881082,34959373,30592961,31963936,25011471,28881142,27750438,14744390,10782909,29435346,36413750,25451569,21213030,23627345,33859710,11866799,29078089,25908974,28768659,28078026,7774341,34575422,20224351,15527170,29621494,25549765,35647334,23055766,34712695,31281400,25973049,25257407,34523300,32131645,32059509,29842861,24623217,23776397,30402225,11044256,33204767,8988847,28721202,28344826,23991101,10846905,34429627,18472820,24049647,25587321,26379748,27334509,35310428,25478189,35448536,36882317,8819184,18475441,14582896,35885778,30774959,24009861,17686584,4451630,22078633,33149866,30204378,24684897,31346884,21950129,25770093,34589667,31949716,21067617,1571282,24978193,32218380,18475582,30465455,29978355,8781511,30721425,18396374,32943901,11172686,36268116,31016478,24303350,11839543,24812589,30519071,6298109,36059986,36349282,24342001,33692687,31937144,27929748,21787233,37119392,33322573,35631365,8475995,33537146,150902,35379863,36959687,15760391,34880683,18472868,25598708,33519502,32388942,15449984,31737228,7732911,26872701,24333504,35111515,36404927,35021537,8109825,36594854,23320022,31362372,34064389,8665787,30783524,21784007,30792658,25908984,36928557,26977143,30702081,29234179,36060625,33447364,35721668,18472777,32509240,28962246,23619612,15402548[uid]

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Pretreatment with olprinone hydrochloride, a phosphodiesterase III inhibitor, attenuates lipopolysaccharide-induced lung injury via an anti-inflammatory effect.

Koike T, Nadeen Qutab M, Tsuchida M, Takekubo M, Saito M, Hayashi J. Koike T, et al. Pulm Pharmacol Ther. 2008;21(1):166-71. doi: 10.1016/j.pupt.2007.01.007. Epub 2007 Feb 14. Pulm Pharmacol Ther. 2008. PMID: 17434327

Ghrelin attenuates lipopolysaccharide-induced acute lung injury through NO pathway.

Chen J, Liu X, Shu Q, Li S, Luo F. Chen J, et al. Med Sci Monit. 2008 Jul;14(7):BR141-6. Med Sci Monit. 2008. PMID: 18591913

Selective phosphodiesterase 3 inhibitor olprinone attenuates meconium-induced oxidative lung injury.

Mokra D, Drgova A, Pullmann R Sr, Calkovska A. Mokra D, et al. Pulm Pharmacol Ther. 2012 Jun;25(3):216-22. doi: 10.1016/j.pupt.2012.02.007. Epub 2012 Feb 25. Pulm Pharmacol Ther. 2012. PMID: 22387424

The effect of LPS on cytokine synthesis and lung neutrophil influx after hepatic ischemia/reperfusion injury in the rat.

Carrick JB, Martins O Jr, Snider CC, Means ND, Enderson BL, Frame SB, Morris SA, Karlstad MD. Carrick JB, et al. J Surg Res. 1997 Feb 15;68(1):16-23. doi: 10.1006/jsre.1997.4998. J Surg Res. 1997. PMID: 9126190

Low intensity laser therapy (LILT) in vivo acts on the neutrophils recruitment and chemokines/cytokines levels in a model of acute pulmonary inflammation induced by aerosol of lipopolysaccharide from Escherichia coli in rat.

Mafra de Lima F, Villaverde AB, Salgado MA, Castro-Faria-Neto HC, Munin E, Albertini R, Aimbire F. Mafra de Lima F, et al. J Photochem Photobiol B. 2010 Dec 2;101(3):271-8. doi: 10.1016/j.jphotobiol.2010.07.012. Epub 2010 Jul 27. J Photochem Photobiol B. 2010. PMID: 20728373

Glucocorticoid effects in an endotoxin-induced rat pulmonary inflammation model: differential effects on neutrophil influx, integrin expression, and inflammatory mediators.

O'Leary EC, Marder P, Zuckerman SH. O'Leary EC, et al. Am J Respir Cell Mol Biol. 1996 Jul;15(1):97-106. doi: 10.1165/ajrcmb.15.1.8679228. Am J Respir Cell Mol Biol. 1996. PMID: 8679228

Preventive and therapeutic effects of Danhong injection on lipopolysaccharide induced acute lung injury in mice.

Wan LM, Tan L, Wang ZR, Liu SX, Wang YL, Liang SY, Zhong JB, Lin HS. Wan LM, et al. J Ethnopharmacol. 2013 Aug 26;149(1):352-9. doi: 10.1016/j.jep.2013.06.048. Epub 2013 Jul 9. J Ethnopharmacol. 2013. PMID: 23850708

Olprinone, a specific phosphodiesterase (PDE)-III inhibitor, reduces the development of multiple organ dysfunction syndrome in mice.

Mazzon E, Esposito E, Di Paola R, Impellizzeri D, Bramanti P, Cuzzocrea S. Mazzon E, et al. Pharmacol Res. 2011 Jul;64(1):68-79. doi: 10.1016/j.phrs.2010.12.010. Epub 2010 Dec 28. Pharmacol Res. 2011. PMID: 21193041

LPS-induced acute lung injury is attenuated by phosphodiesterase inhibition: effects on proinflammatory mediators, metalloproteinases, NF-kappaB, and ICAM-1 expression.

Coimbra R, Melbostad H, Loomis W, Porcides RD, Wolf P, Tobar M, Hoyt DB. Coimbra R, et al. J Trauma. 2006 Jan;60(1):115-25. doi: 10.1097/01.ta.0000200075.12489.74. J Trauma. 2006. PMID: 16456445

Genistein prevents nuclear factor-kappa B activation and acute lung injury induced by lipopolysaccharide.

Kang JL, Lee HW, Lee HS, Pack IS, Chong Y, Castranova V, Koh Y. Kang JL, et al. Am J Respir Crit Care Med. 2001 Dec 15;164(12):2206-12. doi: 10.1164/ajrccm.164.12.2104017. Am J Respir Crit Care Med. 2001. PMID: 11751189

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