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Items: 1 to 20 of 139


Differential effects of trisomy on brain shape and volume in related aneuploid mouse models.

Aldridge K, Reeves RH, Olson LE, Richtsmeier JT.

Am J Med Genet A. 2007 May 15;143A(10):1060-70.


Trisomy for the Down syndrome 'critical region' is necessary but not sufficient for brain phenotypes of trisomic mice.

Olson LE, Roper RJ, Sengstaken CL, Peterson EA, Aquino V, Galdzicki Z, Siarey R, Pletnikov M, Moran TH, Reeves RH.

Hum Mol Genet. 2007 Apr 1;16(7):774-82. Epub 2007 Mar 5.


Down syndrome mouse models Ts65Dn, Ts1Cje, and Ms1Cje/Ts65Dn exhibit variable severity of cerebellar phenotypes.

Olson LE, Roper RJ, Baxter LL, Carlson EJ, Epstein CJ, Reeves RH.

Dev Dyn. 2004 Jul;230(3):581-9.


Discovery and genetic localization of Down syndrome cerebellar phenotypes using the Ts65Dn mouse.

Baxter LL, Moran TH, Richtsmeier JT, Troncoso J, Reeves RH.

Hum Mol Genet. 2000 Jan 22;9(2):195-202.


The "Down syndrome critical region" is sufficient in the mouse model to confer behavioral, neurophysiological, and synaptic phenotypes characteristic of Down syndrome.

Belichenko NP, Belichenko PV, Kleschevnikov AM, Salehi A, Reeves RH, Mobley WC.

J Neurosci. 2009 May 6;29(18):5938-48. doi: 10.1523/JNEUROSCI.1547-09.2009.


Gene expression from the aneuploid chromosome in a trisomy mouse model of down syndrome.

Lyle R, Gehrig C, Neergaard-Henrichsen C, Deutsch S, Antonarakis SE.

Genome Res. 2004 Jul;14(7):1268-74.


Developmental instability of the cerebellum and its relevance to Down syndrome.

Shapiro BL.

J Neural Transm Suppl. 2001;(61):11-34. Review.


Trisomic and allelic differences influence phenotypic variability during development of Down syndrome mice.

Deitz SL, Roper RJ.

Genetics. 2011 Dec;189(4):1487-95. doi: 10.1534/genetics.111.131391. Epub 2011 Sep 16.


A chromosome 21 critical region does not cause specific Down syndrome phenotypes.

Olson LE, Richtsmeier JT, Leszl J, Reeves RH.

Science. 2004 Oct 22;306(5696):687-90.


Highly penetrant myeloproliferative disease in the Ts65Dn mouse model of Down syndrome.

Kirsammer G, Jilani S, Liu H, Davis E, Gurbuxani S, Le Beau MM, Crispino JD.

Blood. 2008 Jan 15;111(2):767-75. Epub 2007 Sep 27.


Microstructure of trabecular bone in a mouse model for Down syndrome.

Parsons T, Ryan TM, Reeves RH, Richtsmeier JT.

Anat Rec (Hoboken). 2007 Apr;290(4):414-21.


Parallels of craniofacial maldevelopment in Down syndrome and Ts65Dn mice.

Richtsmeier JT, Baxter LL, Reeves RH.

Dev Dyn. 2000 Feb;217(2):137-45.


Overlapping trisomies for human chromosome 21 orthologs produce similar effects on skull and brain morphology of Dp(16)1Yey and Ts65Dn mice.

Starbuck JM, Dutka T, Ratliff TS, Reeves RH, Richtsmeier JT.

Am J Med Genet A. 2014 Aug;164A(8):1981-90. doi: 10.1002/ajmg.a.36594. Epub 2014 May 1.


Down syndrome gene dosage imbalance on cerebellum development.

Moldrich RX, Dauphinot L, Laffaire J, Rossier J, Potier MC.

Prog Neurobiol. 2007 Jun;82(2):87-94. Epub 2007 Feb 23. Review.


Craniofacial phenotypes in segmentally trisomic mouse models for Down syndrome.

Richtsmeier JT, Zumwalt A, Carlson EJ, Epstein CJ, Reeves RH.

Am J Med Genet. 2002 Feb 1;107(4):317-24.


Human chromosome 21 orthologous region on mouse chromosome 17 is a major determinant of Down syndrome-related developmental cognitive deficits.

Zhang L, Meng K, Jiang X, Liu C, Pao A, Belichenko PV, Kleschevnikov AM, Josselyn S, Liang P, Ye P, Mobley WC, Yu YE.

Hum Mol Genet. 2014 Feb 1;23(3):578-89. doi: 10.1093/hmg/ddt446. Epub 2013 Sep 16.


On the cause of mental retardation in Down syndrome: extrapolation from full and segmental trisomy 16 mouse models.

Galdzicki Z, Siarey R, Pearce R, Stoll J, Rapoport SI.

Brain Res Brain Res Rev. 2001 Apr;35(2):115-45. Review.


Identification of the translocation breakpoints in the Ts65Dn and Ts1Cje mouse lines: relevance for modeling Down syndrome.

Duchon A, Raveau M, Chevalier C, Nalesso V, Sharp AJ, Herault Y.

Mamm Genome. 2011 Dec;22(11-12):674-84. doi: 10.1007/s00335-011-9356-0. Epub 2011 Sep 28.


Chronic up-regulation of the SHH pathway normalizes some developmental effects of trisomy in Ts65Dn mice.

Dutka T, Hallberg D, Reeves RH.

Mech Dev. 2015 Feb;135:68-80. doi: 10.1016/j.mod.2014.11.004. Epub 2014 Dec 12.


Loss of correlations among proteins in brains of the Ts65Dn mouse model of down syndrome.

Ahmed MM, Sturgeon X, Ellison M, Davisson MT, Gardiner KJ.

J Proteome Res. 2012 Feb 3;11(2):1251-63. doi: 10.1021/pr2011582. Epub 2012 Jan 25.

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