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Results: 1 to 20 of 257

1.

Potent bradykinin B1 receptor antagonists: 4-substituted phenyl cyclohexanes.

Su DS, Lim JL, Markowitz MK, Wan BL, Murphy KL, Reiss DR, Harrell CM, O'Malley SS, Ransom RW, Chang RS, Pettibone DJ, Tang C, Prueksaritanont T, Freidinger RM, Bock MG.

Bioorg Med Chem Lett. 2007 Jun 1;17(11):3006-9. Epub 2007 Mar 21.

PMID:
17428657
[PubMed - indexed for MEDLINE]
2.

Cyclopropylamino acid amide as a pharmacophoric replacement for 2,3-diaminopyridine. Application to the design of novel bradykinin B1 receptor antagonists.

Wood MR, Schirripa KM, Kim JJ, Wan BL, Murphy KL, Ransom RW, Chang RS, Tang C, Prueksaritanont T, Detwiler TJ, Hettrick LA, Landis ER, Leonard YM, Krueger JA, Lewis SD, Pettibone DJ, Freidinger RM, Bock MG.

J Med Chem. 2006 Feb 23;49(4):1231-4.

PMID:
16480259
[PubMed - indexed for MEDLINE]
3.

2,3-diaminopyridine bradykinin B1 receptor antagonists.

Kuduk SD, Ng C, Feng DM, Wai JM, Chang RS, Harrell CM, Murphy KL, Ransom RW, Reiss D, Ivarsson M, Mason G, Boyce S, Tang C, Prueksaritanont T, Freidinger RM, Pettibone DJ, Bock MG.

J Med Chem. 2004 Dec 16;47(26):6439-42.

PMID:
15588075
[PubMed - indexed for MEDLINE]
4.

A new class of bradykinin 1 receptor antagonists containing the piperidine acetic acid tetralin core.

Fotsch C, Biddlecome G, Biswas K, Chen JJ, D'Amico DC, Groneberg RD, Han NB, Hsieh FY, Kamassah A, Kumar G, Lester-Zeiner D, Liu Q, Mareska DA, Riahi BB, Wang YJ, Yang K, Zhan J, Zhu J, Johnson E, Ng G, Askew BC.

Bioorg Med Chem Lett. 2006 Apr 15;16(8):2071-5. Epub 2006 Feb 7.

PMID:
16464576
[PubMed - indexed for MEDLINE]
5.

2-Aminobenzophenones as a novel class of bradykinin B1 receptor antagonists.

Su DS, Lim JL, Tinney E, Wan BL, Murphy KL, Reiss DR, Harrell CM, O'Malley SS, Ransom RW, Chang RS, Pettibone DJ, Yu J, Tang C, Prueksaritanont T, Freidinger RM, Bock MG, Anthony NJ.

J Med Chem. 2008 Jul 10;51(13):3946-52. doi: 10.1021/jm800199h. Epub 2008 Jun 14.

PMID:
18553956
[PubMed - indexed for MEDLINE]
6.

Development of orally bioavailable and CNS penetrant biphenylaminocyclopropane carboxamide bradykinin B1 receptor antagonists.

Kuduk SD, Di Marco CN, Chang RK, Wood MR, Schirripa KM, Kim JJ, Wai JM, DiPardo RM, Murphy KL, Ransom RW, Harrell CM, Reiss DR, Holahan MA, Cook J, Hess JF, Sain N, Urban MO, Tang C, Prueksaritanont T, Pettibone DJ, Bock MG.

J Med Chem. 2007 Jan 25;50(2):272-82.

PMID:
17228869
[PubMed - indexed for MEDLINE]
7.

Discovery of a potent, non-peptide bradykinin B1 receptor antagonist.

Su DS, Markowitz MK, DiPardo RM, Murphy KL, Harrell CM, O'Malley SS, Ransom RW, Chang RS, Ha S, Hess FJ, Pettibone DJ, Mason GS, Boyce S, Freidinger RM, Bock MG.

J Am Chem Soc. 2003 Jun 25;125(25):7516-7.

PMID:
12812482
[PubMed - indexed for MEDLINE]
8.

Potent nonpeptide antagonists of the bradykinin B1 receptor: structure-activity relationship studies with novel diaminochroman carboxamides.

Biswas K, Li A, Chen JJ, D'Amico DC, Fotsch C, Han N, Human J, Liu Q, Norman MH, Riahi B, Yuan C, Suzuki H, Mareska DA, Zhan J, Clarke DE, Toro A, Groneberg RD, Burgess LE, Lester-Zeiner D, Biddlecome G, Manning BH, Arik L, Dong H, Huang M, Kamassah A, Loeloff R, Sun H, Hsieh FY, Kumar G, Ng GY, Hungate RW, Askew BC, Johnson E.

J Med Chem. 2007 May 3;50(9):2200-12. Epub 2007 Apr 5.

PMID:
17408249
[PubMed - indexed for MEDLINE]
9.

Bradykinin B1 receptor antagonists as novel analgesics: a retrospective of selected medicinal chemistry developments.

Kuduk SD, Bock MG.

Curr Top Med Chem. 2008;8(16):1420-30. Review.

PMID:
18991728
[PubMed - indexed for MEDLINE]
10.

A novel class of orally active non-peptide bradykinin B2 receptor antagonists. 3. Discovering bioisosteres of the imidazo[1,2-a] pyridine moiety.

Abe Y, Kayakiri H, Satoh S, Inoue T, Sawada Y, Inamura N, Asano M, Aramori I, Hatori C, Sawai H, Oku T, Tanaka H.

J Med Chem. 1998 Oct 8;41(21):4062-79.

PMID:
9767643
[PubMed - indexed for MEDLINE]
11.

A novel class of orally active non-peptide bradykinin B2 receptor antagonists. 2. Overcoming the species difference between guinea pig and man.

Abe Y, Kayakiri H, Satoh S, Inoue T, Sawada Y, Inamura N, Asano M, Hatori C, Sawai H, Oku T, Tanaka H.

J Med Chem. 1998 Oct 8;41(21):4053-61.

PMID:
9767642
[PubMed - indexed for MEDLINE]
12.

Aryl sulfones as novel bradykinin B1 receptor antagonists for treatment of chronic pain.

Biswas K, Aya T, Qian W, Peterkin TA, Chen JJ, Human J, Hungate RW, Kumar G, Arik L, Lester-Zeiner D, Biddlecome G, Manning BH, Sun H, Dong H, Huang M, Loeloff R, Johnson EJ, Askew BC.

Bioorg Med Chem Lett. 2008 Sep 1;18(17):4764-9. doi: 10.1016/j.bmcl.2008.07.108. Epub 2008 Jul 31.

PMID:
18706809
[PubMed - indexed for MEDLINE]
13.

Pharmacological, pharmacokinetic, and primate analgesic efficacy profile of the novel bradykinin B1 Receptor antagonist ELN441958.

Hawkinson JE, Szoke BG, Garofalo AW, Hom DS, Zhang H, Dreyer M, Fukuda JY, Chen L, Samant B, Simmonds S, Zeitz KP, Wadsworth A, Liao A, Chavez RA, Zmolek W, Ruslim L, Bova MP, Holcomb R, Butelman ER, Ko MC, Malmberg AB.

J Pharmacol Exp Ther. 2007 Aug;322(2):619-30. Epub 2007 Apr 30.

PMID:
17470643
[PubMed - indexed for MEDLINE]
Free Article
14.

Targeting the bradykinin B1 receptor to reduce pain.

Chen JJ, Johnson EJ.

Expert Opin Ther Targets. 2007 Jan;11(1):21-35. Review.

PMID:
17150032
[PubMed - indexed for MEDLINE]
15.

2,3-Diaminopyridine as a platform for designing structurally unique nonpeptide bradykinin B1 receptor antagonists.

Feng DM, Wai JM, Kuduk SD, Ng C, Murphy KL, Ransom RW, Reiss D, Chang RS, Harrell CM, MacNeil T, Tang C, Prueksaritanont T, Freidinger RM, Pettibone DJ, Bock MG.

Bioorg Med Chem Lett. 2005 May 2;15(9):2385-8.

PMID:
15837330
[PubMed - indexed for MEDLINE]
16.

Practical synthesis of a potent bradykinin B(1) antagonist via enantioselective hydrogenation of a pyridyl N-acyl enamide.

O'Shea PD, Gauvreau D, Gosselin F, Hughes G, Nadeau C, Roy A, Shultz CS.

J Org Chem. 2009 Jun 19;74(12):4547-53. doi: 10.1021/jo802772d.

PMID:
19456171
[PubMed - indexed for MEDLINE]
17.

Bradykinin B1 antagonists: biphenyl SAR studies in the cyclopropanecarboxamide series.

Kuduk SD, DiPardo RM, Chang RK, Di Marco CN, Murphy KL, Ransom RW, Reiss DR, Tang C, Prueksaritanont T, Pettibone DJ, Bock MG.

Bioorg Med Chem Lett. 2007 Jul 1;17(13):3608-12. Epub 2007 Apr 24.

PMID:
17482459
[PubMed - indexed for MEDLINE]
18.

Synthesis and pharmacological evaluation of pyrazoline derivatives as new anti-inflammatory and analgesic agents.

Amir M, Kumar H, Khan SA.

Bioorg Med Chem Lett. 2008 Feb 1;18(3):918-22. doi: 10.1016/j.bmcl.2007.12.043. Epub 2008 Jan 7.

PMID:
18182288
[PubMed - indexed for MEDLINE]
19.

From bradykinin B2 receptor antagonists to orally active and selective bradykinin B1 receptor antagonists.

Barth M, Bondoux M, Luccarini JM, Peyrou V, Dodey P, Pruneau D, Massardier C, Paquet JL.

J Med Chem. 2012 Mar 22;55(6):2574-84. doi: 10.1021/jm2016057. Epub 2012 Mar 6.

PMID:
22369198
[PubMed - indexed for MEDLINE]
20.

Antinociceptive pharmacology of N-[[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]methyl]-2-[2-[[(4-methoxy-2,6-dimethylphenyl) sulfonyl]methylamino]ethoxy]-N-methylacetamide, fumarate (LF22-0542), a novel nonpeptidic bradykinin B1 receptor antagonist.

Porreca F, Vanderah TW, Guo W, Barth M, Dodey P, Peyrou V, Luccarini JM, Junien JL, Pruneau D.

J Pharmacol Exp Ther. 2006 Jul;318(1):195-205. Epub 2006 Mar 24.

PMID:
16565167
[PubMed - indexed for MEDLINE]
Free Article

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