Similar articles for PMID: 17398090

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1

Dual M3 antagonists-PDE4 inhibitors. Part 2: Synthesis and SAR of 3-substituted azetidinyl derivatives.

Provins L, Christophe B, Danhaive P, Dulieu J, Gillard M, Quéré L, Stebbins K. Provins L, et al. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3077-80. doi: 10.1016/j.bmcl.2007.03.047. Epub 2007 Mar 19. Bioorg Med Chem Lett. 2007. PMID: 17398090

2

First dual M3 antagonists-PDE4 inhibitors: synthesis and SAR of 4,6-diaminopyrimidine derivatives.

Provins L, Christophe B, Danhaive P, Dulieu J, Durieu V, Gillard M, Lebon F, Lengelé S, Quéré L, van Keulen B. Provins L, et al. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1834-9. doi: 10.1016/j.bmcl.2006.01.006. Epub 2006 Jan 24. Bioorg Med Chem Lett. 2006. PMID: 16439121

3

Discovery of a substituted 8-arylquinoline series of PDE4 inhibitors: structure-activity relationship, optimization, and identification of a highly potent, well tolerated, PDE4 inhibitor.

Macdonald D, Mastracchio A, Perrier H, Dubé D, Gallant M, Lacombe P, Deschênes D, Roy B, Scheigetz J, Bateman K, Li C, Trimble LA, Day S, Chauret N, Nicoll-Griffith DA, Silva JM, Huang Z, Laliberté F, Liu S, Ethier D, Pon D, Muise E, Boulet L, Chan CC, Styhler A, Charleson S, Mancini J, Masson P, Claveau D, Nicholson D, Turner M, Young RN, Girard Y. Macdonald D, et al. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5241-6. doi: 10.1016/j.bmcl.2005.08.036. Epub 2005 Sep 15. Bioorg Med Chem Lett. 2005. PMID: 16168647

4

8-Substituted analogues of 3-(3-cyclopentyloxy-4-methoxy-benzyl)-8-isopropyl-adenine: highly potent and selective PDE4 inhibitors.

Whitehead JW, Lee GP, Gharagozloo P, Hofer P, Gehrig A, Wintergerst P, Smyth D, McCoull W, Hachicha M, Patel A, Kyle DJ. Whitehead JW, et al. J Med Chem. 2005 Feb 24;48(4):1237-43. doi: 10.1021/jm030603w. J Med Chem. 2005. PMID: 15715490

5

Discovery of thiadiazoles as a novel structural class of potent and selective PDE7 inhibitors. Part 1: design, synthesis and structure-activity relationship studies.

Vergne F, Bernardelli P, Lorthiois E, Pham N, Proust E, Oliveira C, Mafroud AK, Royer F, Wrigglesworth R, Schellhaas J, Barvian M, Moreau F, Idrissi M, Tertre A, Bertin B, Coupe M, Berna P, Soulard P. Vergne F, et al. Bioorg Med Chem Lett. 2004 Sep 20;14(18):4607-13. doi: 10.1016/j.bmcl.2004.07.008. Bioorg Med Chem Lett. 2004. PMID: 15324874

6

2,1,3-Benzothiadiazine derivatives: synthesis and screening versus PDE4 enzyme.

Tait A, Luppi A, Avallone R, Baraldi M. Tait A, et al. Farmaco. 2005 Aug;60(8):653-63. doi: 10.1016/j.farmac.2005.05.009. Farmaco. 2005. PMID: 15963514

7

Synthesis and structure-activity relationships of cis-tetrahydrophthalazinone/pyridazinone hybrids: a novel series of potent dual PDE3/PDE4 inhibitory agents.

Van der Mey M, Bommelé KM, Boss H, Hatzelmann A, Van Slingerland M, Sterk GJ, Timmerman H. Van der Mey M, et al. J Med Chem. 2003 May 8;46(10):2008-16. doi: 10.1021/jm030776l. J Med Chem. 2003. PMID: 12723963

8

Design and synthesis of novel imidazo[1,2-a]quinoxalines as PDE4 inhibitors.

Deleuze-Masquéfa C, Gerebtzoff G, Subra G, Fabreguettes JR, Ovens A, Carraz M, Strub MP, Bompart J, George P, Bonnet PA. Deleuze-Masquéfa C, et al. Bioorg Med Chem. 2004 Mar 1;12(5):1129-39. doi: 10.1016/j.bmc.2003.11.034. Bioorg Med Chem. 2004. PMID: 14980625

9

Fused pyrimidine based inhibitors of phosphodiesterase 7 (PDE7): synthesis and initial structure-activity relationships.

Kempson J, Pitts WJ, Barbosa J, Guo J, Omotoso O, Watson A, Stebbins K, Starling GC, Dodd JH, Barrish JC, Felix R, Fischer K. Kempson J, et al. Bioorg Med Chem Lett. 2005 Apr 1;15(7):1829-33. doi: 10.1016/j.bmcl.2005.02.025. Bioorg Med Chem Lett. 2005. PMID: 15780616

10

New orally active PDE4 inhibitors with therapeutic potential.

Ochiai H, Ishida A, Ohtani T, Kusumi K, Kishikawa K, Yamamoto S, Takeda H, Obata T, Nakai H, Toda M. Ochiai H, et al. Bioorg Med Chem. 2004 Aug 1;12(15):4089-100. doi: 10.1016/j.bmc.2004.05.032. Bioorg Med Chem. 2004. PMID: 15246087

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