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Results: 1 to 20 of 150

1.

Mutation studies of Ser7.39 and Ser2.60 in the human CB1 cannabinoid receptor: evidence for a serine-induced bend in CB1 transmembrane helix 7.

Kapur A, Hurst DP, Fleischer D, Whitnell R, Thakur GA, Makriyannis A, Reggio PH, Abood ME.

Mol Pharmacol. 2007 Jun;71(6):1512-24. Epub 2007 Mar 23.

PMID:
17384224
[PubMed - indexed for MEDLINE]
Free Article
2.

Mapping the structural requirements in the CB1 cannabinoid receptor transmembrane helix II for signal transduction.

Kapur A, Samaniego P, Thakur GA, Makriyannis A, Abood ME.

J Pharmacol Exp Ther. 2008 Apr;325(1):341-8. doi: 10.1124/jpet.107.133256. Epub 2008 Jan 3.

PMID:
18174385
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Antiemetic and motor-depressive actions of CP55,940: cannabinoid CB1 receptor characterization, distribution, and G-protein activation.

Darmani NA, Sim-Selley LJ, Martin BR, Janoyan JJ, Crim JL, Parekh B, Breivogel CS.

Eur J Pharmacol. 2003 Jan 10;459(1):83-95.

PMID:
12505537
[PubMed - indexed for MEDLINE]
4.

(-)-7'-Isothiocyanato-11-hydroxy-1',1'-dimethylheptylhexahydrocannabinol (AM841), a high-affinity electrophilic ligand, interacts covalently with a cysteine in helix six and activates the CB1 cannabinoid receptor.

Picone RP, Khanolkar AD, Xu W, Ayotte LA, Thakur GA, Hurst DP, Abood ME, Reggio PH, Fournier DJ, Makriyannis A.

Mol Pharmacol. 2005 Dec;68(6):1623-35. Epub 2005 Sep 12.

PMID:
16157695
[PubMed - indexed for MEDLINE]
Free Article
5.

Novel insights into CB1 cannabinoid receptor signaling: a key interaction identified between the extracellular-3 loop and transmembrane helix 2.

Marcu J, Shore DM, Kapur A, Trznadel M, Makriyannis A, Reggio PH, Abood ME.

J Pharmacol Exp Ther. 2013 May;345(2):189-97. doi: 10.1124/jpet.112.201046. Epub 2013 Feb 20.

PMID:
23426954
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Mutational analysis and molecular modelling of the antagonist SR 144528 binding site on the human cannabinoid CB(2) receptor.

Gouldson P, Calandra B, Legoux P, Kernéis A, Rinaldi-Carmona M, Barth F, Le Fur G, Ferrara P, Shire D.

Eur J Pharmacol. 2000 Jul 28;401(1):17-25.

PMID:
10915832
[PubMed - indexed for MEDLINE]
7.

Role of a conserved lysine residue in the peripheral cannabinoid receptor (CB2): evidence for subtype specificity.

Tao Q, McAllister SD, Andreassi J, Nowell KW, Cabral GA, Hurst DP, Bachtel K, Ekman MC, Reggio PH, Abood ME.

Mol Pharmacol. 1999 Mar;55(3):605-13.

PMID:
10051546
[PubMed - indexed for MEDLINE]
Free Article
8.

Sphingosine and its analog, the immunosuppressant 2-amino-2-(2-[4-octylphenyl]ethyl)-1,3-propanediol, interact with the CB1 cannabinoid receptor.

Paugh SW, Cassidy MP, He H, Milstien S, Sim-Selley LJ, Spiegel S, Selley DE.

Mol Pharmacol. 2006 Jul;70(1):41-50. Epub 2006 Mar 29.

PMID:
16571654
[PubMed - indexed for MEDLINE]
Free Article
9.

An aromatic microdomain at the cannabinoid CB(1) receptor constitutes an agonist/inverse agonist binding region.

McAllister SD, Rizvi G, Anavi-Goffer S, Hurst DP, Barnett-Norris J, Lynch DL, Reggio PH, Abood ME.

J Med Chem. 2003 Nov 20;46(24):5139-52.

PMID:
14613317
[PubMed - indexed for MEDLINE]
10.

Structural mimicry in class A G protein-coupled receptor rotamer toggle switches: the importance of the F3.36(201)/W6.48(357) interaction in cannabinoid CB1 receptor activation.

McAllister SD, Hurst DP, Barnett-Norris J, Lynch D, Reggio PH, Abood ME.

J Biol Chem. 2004 Nov 12;279(46):48024-37. Epub 2004 Aug 23.

PMID:
15326174
[PubMed - indexed for MEDLINE]
Free Article
11.

Allosteric modulation of the cannabinoid CB1 receptor.

Price MR, Baillie GL, Thomas A, Stevenson LA, Easson M, Goodwin R, McLean A, McIntosh L, Goodwin G, Walker G, Westwood P, Marrs J, Thomson F, Cowley P, Christopoulos A, Pertwee RG, Ross RA.

Mol Pharmacol. 2005 Nov;68(5):1484-95. Epub 2005 Aug 19.

PMID:
16113085
[PubMed - indexed for MEDLINE]
Free Article
12.

Helix 8 Leu in the CB1 cannabinoid receptor contributes to selective signal transduction mechanisms.

Anavi-Goffer S, Fleischer D, Hurst DP, Lynch DL, Barnett-Norris J, Shi S, Lewis DL, Mukhopadhyay S, Howlett AC, Reggio PH, Abood ME.

J Biol Chem. 2007 Aug 24;282(34):25100-13. Epub 2007 Jun 26.

PMID:
17595161
[PubMed - indexed for MEDLINE]
Free Article
13.

WIN55212-2 docking to the CB1 cannabinoid receptor and multiple pathways for conformational induction.

Shim JY, Howlett AC.

J Chem Inf Model. 2006 May-Jun;46(3):1286-300.

PMID:
16711748
[PubMed - indexed for MEDLINE]
14.

Effects of the allosteric antagonist 1-(4-chlorophenyl)-3-[3-(6-pyrrolidin-1-ylpyridin-2-yl)phenyl]urea (PSNCBAM-1) on CB1 receptor modulation in the cerebellum.

Wang X, Horswill JG, Whalley BJ, Stephens GJ.

Mol Pharmacol. 2011 Apr;79(4):758-67. doi: 10.1124/mol.110.068197. Epub 2010 Dec 28.

PMID:
21189269
[PubMed - indexed for MEDLINE]
Free Article
15.

Biarylpyrazole inverse agonists at the cannabinoid CB1 receptor: importance of the C-3 carboxamide oxygen/lysine3.28(192) interaction.

Hurst D, Umejiego U, Lynch D, Seltzman H, Hyatt S, Roche M, McAllister S, Fleischer D, Kapur A, Abood M, Shi S, Jones J, Lewis D, Reggio P.

J Med Chem. 2006 Oct 5;49(20):5969-87.

PMID:
17004712
[PubMed - indexed for MEDLINE]
16.

Allosteric modulator ORG27569 induces CB1 cannabinoid receptor high affinity agonist binding state, receptor internalization, and Gi protein-independent ERK1/2 kinase activation.

Ahn KH, Mahmoud MM, Kendall DA.

J Biol Chem. 2012 Apr 6;287(15):12070-82. doi: 10.1074/jbc.M111.316463. Epub 2012 Feb 16.

PMID:
22343625
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A) interaction with LYS 3.28(192) is crucial for its inverse agonism at the cannabinoid CB1 receptor.

Hurst DP, Lynch DL, Barnett-Norris J, Hyatt SM, Seltzman HH, Zhong M, Song ZH, Nie J, Lewis D, Reggio PH.

Mol Pharmacol. 2002 Dec;62(6):1274-87.

PMID:
12435794
[PubMed - indexed for MEDLINE]
Free Article
18.

F200A substitution in the third transmembrane helix of human cannabinoid CB1 receptor converts AM2233 from receptor agonist to inverse agonist.

Shen CP, Xiao JC, Armstrong H, Hagmann W, Fong TM.

Eur J Pharmacol. 2006 Feb 15;531(1-3):41-6. Epub 2006 Jan 24.

PMID:
16438957
[PubMed - indexed for MEDLINE]
19.

Characterization of active and inactive states of CB1 receptor and the differential binding state modulation by cannabinoid agonists, antagonists and inverse agonists.

Gullapalli S, Amrutkar D, Gupta S, Kandadi MR, Kumar H, Gandhi M, Karande V, Narayanan S.

Neuropharmacology. 2010 Jun;58(8):1215-9. doi: 10.1016/j.neuropharm.2010.03.001. Epub 2010 Mar 7.

PMID:
20214912
[PubMed - indexed for MEDLINE]
20.

Virodhamine and CP55,940 modulate cAMP production and IL-8 release in human bronchial epithelial cells.

Gkoumassi E, Dekkers BG, Dröge MJ, Elzinga CR, Schmidt M, Meurs H, Zaagsma J, Nelemans SA.

Br J Pharmacol. 2007 Aug;151(7):1041-8. Epub 2007 Jun 11.

PMID:
17558435
[PubMed - indexed for MEDLINE]
Free PMC Article

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