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Items: 1 to 20 of 96

1.

Life extension through neurofibromin mitochondrial regulation and antioxidant therapy for neurofibromatosis-1 in Drosophila melanogaster.

Tong JJ, Schriner SE, McCleary D, Day BJ, Wallace DC.

Nat Genet. 2007 Apr;39(4):476-85. Epub 2007 Mar 18.

PMID:
17369827
3.

Neurofibromin regulates G protein-stimulated adenylyl cyclase activity.

Tong J, Hannan F, Zhu Y, Bernards A, Zhong Y.

Nat Neurosci. 2002 Feb;5(2):95-6.

PMID:
11788835
4.

Effect of neurofibromatosis type I mutations on a novel pathway for adenylyl cyclase activation requiring neurofibromin and Ras.

Hannan F, Ho I, Tong JJ, Zhu Y, Nurnberg P, Zhong Y.

Hum Mol Genet. 2006 Apr 1;15(7):1087-98. Epub 2006 Mar 2.

5.

Sensitivity of malignant peripheral nerve sheath tumor cells to TRAIL is augmented by loss of NF1 through modulation of MYC/MAD and is potentiated by curcumin through induction of ROS.

Reuss DE, Mucha J, Hagenlocher C, Ehemann V, Kluwe L, Mautner V, von Deimling A.

PLoS One. 2013;8(2):e57152. doi: 10.1371/journal.pone.0057152. Epub 2013 Feb 21.

6.

Lack of correlation between mitochondrial reactive oxygen species production and life span in Drosophila.

Miwa S, Riyahi K, Partridge L, Brand MD.

Ann N Y Acad Sci. 2004 Jun;1019:388-91. Review.

PMID:
15247051
7.

NF1 deficiency causes Bcl-xL upregulation in Schwann cells derived from neurofibromatosis type 1-associated malignant peripheral nerve sheath tumors.

Park HJ, Lee SJ, Sohn YB, Jin HS, Han JH, Kim YB, Yim H, Jeong SY.

Int J Oncol. 2013 Feb;42(2):657-66. doi: 10.3892/ijo.2012.1751. Epub 2012 Dec 24.

PMID:
23292448
8.

Antioxidant compound supplementation prevents oxidative damage in a Drosophila model of Parkinson's disease.

Casani S, Gómez-Pastor R, Matallana E, Paricio N.

Free Radic Biol Med. 2013 Aug;61:151-60. doi: 10.1016/j.freeradbiomed.2013.03.021. Epub 2013 Mar 31.

PMID:
23548634
9.

Reduced growth of Drosophila neurofibromatosis 1 mutants reflects a non-cell-autonomous requirement for GTPase-Activating Protein activity in larval neurons.

Walker JA, Tchoudakova AV, McKenney PT, Brill S, Wu D, Cowley GS, Hariharan IK, Bernards A.

Genes Dev. 2006 Dec 1;20(23):3311-23. Epub 2006 Nov 17.

10.

Overexpression of the small mitochondrial Hsp22 extends Drosophila life span and increases resistance to oxidative stress.

Morrow G, Samson M, Michaud S, Tanguay RM.

FASEB J. 2004 Mar;18(3):598-9. Epub 2004 Jan 20.

11.

Neurofibromatosis type 1 (NF1) tumor suppressor, neurofibromin, regulates the neuronal differentiation of PC12 cells via its associating protein, CRMP-2.

Patrakitkomjorn S, Kobayashi D, Morikawa T, Wilson MM, Tsubota N, Irie A, Ozawa T, Aoki M, Arimura N, Kaibuchi K, Saya H, Araki N.

J Biol Chem. 2008 Apr 4;283(14):9399-413. doi: 10.1074/jbc.M708206200. Epub 2008 Jan 23.

12.

The Ras inhibitor farnesylthiosalicylic acid as a potential therapy for neurofibromatosis type 1.

Barkan B, Starinsky S, Friedman E, Stein R, Kloog Y.

Clin Cancer Res. 2006 Sep 15;12(18):5533-42.

PMID:
17000690
13.

Mitochondrial dysfunction and oxidative stress contribute to the pathogenesis of spinocerebellar ataxia type 12 (SCA12).

Wang YC, Lee CM, Lee LC, Tung LC, Hsieh-Li HM, Lee-Chen GJ, Su MT.

J Biol Chem. 2011 Jun 17;286(24):21742-54. doi: 10.1074/jbc.M110.160697. Epub 2011 Apr 6.

14.

Overexpression of frataxin in the mitochondria increases resistance to oxidative stress and extends lifespan in Drosophila.

Runko AP, Griswold AJ, Min KT.

FEBS Lett. 2008 Mar 5;582(5):715-9. doi: 10.1016/j.febslet.2008.01.046. Epub 2008 Feb 5.

15.

Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress.

Schulz TJ, Zarse K, Voigt A, Urban N, Birringer M, Ristow M.

Cell Metab. 2007 Oct;6(4):280-93.

16.

Drosophila melanogaster neurofibromatosis-1: ROS, not Ras?

Walker JA, Bernards A.

Nat Genet. 2007 Apr;39(4):443-5. No abstract available.

PMID:
17392804
17.

Developmental abnormalities and cancer predisposition in neurofibromatosis type 1.

Larizza L, Gervasini C, Natacci F, Riva P.

Curr Mol Med. 2009 Jun;9(5):634-53. Review.

PMID:
19601812
18.

Targeted expression of the human uncoupling protein 2 (hUCP2) to adult neurons extends life span in the fly.

Fridell YW, Sánchez-Blanco A, Silvia BA, Helfand SL.

Cell Metab. 2005 Feb;1(2):145-52.

19.

The neurofibromatosis type 1 gene product neurofibromin enhances cell motility by regulating actin filament dynamics via the Rho-ROCK-LIMK2-cofilin pathway.

Ozawa T, Araki N, Yunoue S, Tokuo H, Feng L, Patrakitkomjorn S, Hara T, Ichikawa Y, Matsumoto K, Fujii K, Saya H.

J Biol Chem. 2005 Nov 25;280(47):39524-33. Epub 2005 Sep 16.

20.

Spatiotemporal differences in CXCL12 expression and cyclic AMP underlie the unique pattern of optic glioma growth in neurofibromatosis type 1.

Warrington NM, Woerner BM, Daginakatte GC, Dasgupta B, Perry A, Gutmann DH, Rubin JB.

Cancer Res. 2007 Sep 15;67(18):8588-95.

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