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Items: 1 to 20 of 167

1.

Mechanism of specific membrane targeting by C2 domains: localized pools of target lipids enhance Ca2+ affinity.

Corbin JA, Evans JH, Landgraf KE, Falke JJ.

Biochemistry. 2007 Apr 10;46(14):4322-36. Epub 2007 Mar 17.

2.

Specific translocation of protein kinase Calpha to the plasma membrane requires both Ca2+ and PIP2 recognition by its C2 domain.

Evans JH, Murray D, Leslie CC, Falke JJ.

Mol Biol Cell. 2006 Jan;17(1):56-66. Epub 2005 Oct 19.

3.

C2 domains from different Ca2+ signaling pathways display functional and mechanistic diversity.

Nalefski EA, Wisner MA, Chen JZ, Sprang SR, Fukuda M, Mikoshiba K, Falke JJ.

Biochemistry. 2001 Mar 13;40(10):3089-100.

4.

Effect of PIP2 binding on the membrane docking geometry of PKC alpha C2 domain: an EPR site-directed spin-labeling and relaxation study.

Landgraf KE, Malmberg NJ, Falke JJ.

Biochemistry. 2008 Aug 12;47(32):8301-16. doi: 10.1021/bi800711t. Epub 2008 Jul 9.

5.
6.

Membrane docking geometry and target lipid stoichiometry of membrane-bound PKCα C2 domain: a combined molecular dynamics and experimental study.

Lai CL, Landgraf KE, Voth GA, Falke JJ.

J Mol Biol. 2010 Sep 17;402(2):301-10. doi: 10.1016/j.jmb.2010.07.037. Epub 2010 Jul 24.

7.

Ca2+-signaling cycle of a membrane-docking C2 domain.

Nalefski EA, Slazas MM, Falke JJ.

Biochemistry. 1997 Oct 7;36(40):12011-8.

PMID:
9340010
8.
9.

Single-molecule studies reveal a hidden key step in the activation mechanism of membrane-bound protein kinase C-α.

Ziemba BP, Li J, Landgraf KE, Knight JD, Voth GA, Falke JJ.

Biochemistry. 2014 Mar 18;53(10):1697-713. doi: 10.1021/bi4016082. Epub 2014 Mar 7.

10.

Location of the membrane-docking face on the Ca2+-activated C2 domain of cytosolic phospholipase A2.

Nalefski EA, Falke JJ.

Biochemistry. 1998 Dec 22;37(51):17642-50.

PMID:
9922129
11.

Membrane binding kinetics of protein kinase C betaII mediated by the C2 domain.

Nalefski EA, Newton AC.

Biochemistry. 2001 Nov 6;40(44):13216-29.

PMID:
11683630
12.

The origin of C1A-C2 interdomain interactions in protein kinase Calpha.

Stahelin RV, Wang J, Blatner NR, Rafter JD, Murray D, Cho W.

J Biol Chem. 2005 Oct 28;280(43):36452-63. Epub 2005 Aug 3.

13.

Determination of the calcium-binding sites of the C2 domain of protein kinase Calpha that are critical for its translocation to the plasma membrane.

Corbalán-García S, Rodríguez-Alfaro JA, Gómez-Fernández JC.

Biochem J. 1999 Feb 1;337 ( Pt 3):513-21.

14.

Membrane docking of the C2 domain from protein kinase Cα as seen by polarized ATR-IR. The role of PIP₂.

Ausili A, Corbalán-García S, Gómez-Fernández JC, Marsh D.

Biochim Biophys Acta. 2011 Mar;1808(3):684-95. doi: 10.1016/j.bbamem.2010.11.035. Epub 2010 Dec 7.

15.

Phosphatidylinositol-4,5-bisphosphate enhances anionic lipid demixing by the C2 domain of PKCα.

Egea-Jiménez AL, Fernández-Martínez AM, Pérez-Lara Á, de Godos A, Corbalán-García S, Gómez-Fernández JC.

PLoS One. 2014 Apr 24;9(4):e95973. doi: 10.1371/journal.pone.0095973. eCollection 2014.

16.

The C2 domain of PKCalpha is a Ca2+ -dependent PtdIns(4,5)P2 sensing domain: a new insight into an old pathway.

Sánchez-Bautista S, Marín-Vicente C, Gómez-Fernández JC, Corbalán-García S.

J Mol Biol. 2006 Oct 6;362(5):901-14. Epub 2006 Aug 9.

PMID:
16949603
17.

Cation charge and size selectivity of the C2 domain of cytosolic phospholipase A(2).

Nalefski EA, Falke JJ.

Biochemistry. 2002 Jan 29;41(4):1109-22.

18.

Additional binding sites for anionic phospholipids and calcium ions in the crystal structures of complexes of the C2 domain of protein kinase calpha.

Ochoa WF, Corbalán-Garcia S, Eritja R, Rodríguez-Alfaro JA, Gómez-Fernández JC, Fita I, Verdaguer N.

J Mol Biol. 2002 Jul 5;320(2):277-91.

PMID:
12079385
19.

The calcium binding loops of the cytosolic phospholipase A2 C2 domain specify targeting to Golgi and ER in live cells.

Evans JH, Gerber SH, Murray D, Leslie CC.

Mol Biol Cell. 2004 Jan;15(1):371-83. Epub 2003 Sep 17.

20.

The membrane binding kinetics of full-length PKCα is determined by membrane lipid composition.

Pérez-Lara A, Egea-Jiménez AL, Ausili A, Corbalán-García S, Gómez-Fernández JC.

Biochim Biophys Acta. 2012 Nov;1821(11):1434-42. doi: 10.1016/j.bbalip.2012.06.012. Epub 2012 Jul 27.

PMID:
22842589
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