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Items: 1 to 20 of 123


Targeted deletion of Wwox reveals a tumor suppressor function.

Aqeilan RI, Trapasso F, Hussain S, Costinean S, Marshall D, Pekarsky Y, Hagan JP, Zanesi N, Kaou M, Stein GS, Lian JB, Croce CM.

Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):3949-54. Epub 2007 Feb 27.


WWOX in biological control and tumorigenesis.

Aqeilan RI, Croce CM.

J Cell Physiol. 2007 Aug;212(2):307-10. Review.


WWOX gene expression abolishes ovarian cancer tumorigenicity in vivo and decreases attachment to fibronectin via integrin alpha3.

Gourley C, Paige AJ, Taylor KJ, Ward C, Kuske B, Zhang J, Sun M, Janczar S, Harrison DJ, Muir M, Smyth JF, Gabra H.

Cancer Res. 2009 Jun 1;69(11):4835-42. doi: 10.1158/0008-5472.CAN-08-2974. Epub 2009 May 19.


WW domain-containing oxidoreductase's role in myriad cancers: clinical significance and future implications.

Gardenswartz A, Aqeilan RI.

Exp Biol Med (Maywood). 2014 Mar;239(3):253-63. doi: 10.1177/1535370213519213. Epub 2014 Feb 7. Review.


Conditional inactivation of the mouse Wwox tumor suppressor gene recapitulates the null phenotype.

Abdeen SK, Del Mare S, Hussain S, Abu-Remaileh M, Salah Z, Hagan J, Rawahneh M, Pu XA, Russell S, Stein JL, Stein GS, Lian JB, Aqeilan RI.

J Cell Physiol. 2013 Jul;228(7):1377-82. doi: 10.1002/jcp.24308.


WWOX: a fragile tumor suppressor.

Schrock MS, Huebner K.

Exp Biol Med (Maywood). 2015 Mar;240(3):296-304. doi: 10.1177/1535370214561590. Epub 2014 Dec 22. Review.


WW domain containing oxidoreductase gene expression is altered in non-small cell lung cancer.

Yendamuri S, Kuroki T, Trapasso F, Henry AC, Dumon KR, Huebner K, Williams NN, Kaiser LR, Croce CM.

Cancer Res. 2003 Feb 15;63(4):878-81.


WWOX hypomorphic mice display a higher incidence of B-cell lymphomas and develop testicular atrophy.

Ludes-Meyers JH, Kil H, Nuñez MI, Conti CJ, Parker-Thornburg J, Bedford MT, Aldaz CM.

Genes Chromosomes Cancer. 2007 Dec;46(12):1129-36.


WWOX: its genomics, partners, and functions.

Del Mare S, Salah Z, Aqeilan RI.

J Cell Biochem. 2009 Nov 1;108(4):737-45. doi: 10.1002/jcb.22298. Review.


Role of the WWOX gene, encompassing fragile region FRA16D, in suppression of pancreatic carcinoma cells.

Nakayama S, Semba S, Maeda N, Aqeilan RI, Huebner K, Yokozaki H.

Cancer Sci. 2008 Jul;99(7):1370-6. doi: 10.1111/j.1349-7006.2008.00841.x. Epub 2008 May 2.


WWOX gene restoration prevents lung cancer growth in vitro and in vivo.

Fabbri M, Iliopoulos D, Trapasso F, Aqeilan RI, Cimmino A, Zanesi N, Yendamuri S, Han SY, Amadori D, Huebner K, Croce CM.

Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15611-6. Epub 2005 Oct 13.


WWOX tumor suppressor gene.

Yang J, Zhang W.

Histol Histopathol. 2008 Jul;23(7):877-82. Review.


Molecular alterations in the tumor suppressor gene WWOX in oral leukoplakias.

Pimenta FJ, Cordeiro GT, Pimenta LG, Viana MB, Lopes J, Gomez MV, Aldaz CM, De Marco L, Gomez RS.

Oral Oncol. 2008 Aug;44(8):753-8. Epub 2007 Dec 3.


Generation and characterization of mice carrying a conditional allele of the Wwox tumor suppressor gene.

Ludes-Meyers JH, Kil H, Parker-Thornburg J, Kusewitt DF, Bedford MT, Aldaz CM.

PLoS One. 2009 Nov 10;4(11):e7775. doi: 10.1371/journal.pone.0007775.


Reversing effect of exogenous WWOX gene expression on malignant phenotype of primary cultured lung carcinoma cells.

Zhou YL, Li YC, Shou F, Liu CQ, Pu Y, Tang H.

Chin Med J (Engl). 2010 Mar 5;123(5):615-20.


Inactivation of the Wwox gene accelerates forestomach tumor progression in vivo.

Aqeilan RI, Hagan JP, Aqeilan HA, Pichiorri F, Fong LY, Croce CM.

Cancer Res. 2007 Jun 15;67(12):5606-10.


Frequent attenuation of the WWOX tumor suppressor in osteosarcoma is associated with increased tumorigenicity and aberrant RUNX2 expression.

Kurek KC, Del Mare S, Salah Z, Abdeen S, Sadiq H, Lee SH, Gaudio E, Zanesi N, Jones KB, DeYoung B, Amir G, Gebhardt M, Warman M, Stein GS, Stein JL, Lian JB, Aqeilan RI.

Cancer Res. 2010 Jul 1;70(13):5577-86. doi: 10.1158/0008-5472.CAN-09-4602. Epub 2010 Jun 8.


The tumor suppressor gene WWOX at FRA16D is involved in pancreatic carcinogenesis.

Kuroki T, Yendamuri S, Trapasso F, Matsuyama A, Aqeilan RI, Alder H, Rattan S, Cesari R, Nolli ML, Williams NN, Mori M, Kanematsu T, Croce CM.

Clin Cancer Res. 2004 Apr 1;10(7):2459-65.


Association study of a functional copy number variation in the WWOX gene with risk of gliomas among Chinese people.

Yu K, Fan J, Ding X, Li C, Wang J, Xiang Y, Wang QS.

Int J Cancer. 2014 Oct 1;135(7):1687-91. doi: 10.1002/ijc.28815. Epub 2014 Apr 21.


WWOX-mediated apoptosis in A549 cells mainly involves the mitochondrial pathway.

Zhang P, Jia R, Ying L, Liu B, Qian G, Fan X, Ge S.

Mol Med Rep. 2012 Jul;6(1):121-4. doi: 10.3892/mmr.2012.860. Epub 2012 Apr 6.

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