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Results: 1 to 20 of 305

1.

Discovery of diaryl imidazolidin-2-one derivatives, a novel class of muscarinic M3 selective antagonists (Part 2).

Peretto I, Fossati C, Giardina GA, Giardini A, Guala M, La Porta E, Petrillo P, Radaelli S, Radice L, Raveglia LF, Santoro E, Scudellaro R, Scarpitta F, Cerri A, Menegon S, Dondio GM, Rizzi A, Armani E, Amari G, Civelli M, Villetti G, Patacchini R, Bergamaschi M, Bassani F, Delcanale M, Imbimbo BP.

J Med Chem. 2007 Apr 5;50(7):1693-7. Epub 2007 Mar 13.

PMID:
17352463
[PubMed - indexed for MEDLINE]
2.

Discovery of diaryl imidazolidin-2-one derivatives, a novel class of muscarinic M3 selective antagonists (Part 1).

Peretto I, Forlani R, Fossati C, Giardina GA, Giardini A, Guala M, La Porta E, Petrillo P, Radaelli S, Radice L, Raveglia LF, Santoro E, Scudellaro R, Scarpitta F, Bigogno C, Misiano P, Dondio GM, Rizzi A, Armani E, Amari G, Civelli M, Villetti G, Patacchini R, Bergamaschi M, Delcanale M, Salcedo C, Fernández AG, Imbimbo BP.

J Med Chem. 2007 Apr 5;50(7):1571-83. Epub 2007 Mar 13.

PMID:
17352462
[PubMed - indexed for MEDLINE]
3.

Bronchodilator activity of (3R)-3-[[[(3-fluorophenyl)[(3,4,5-trifluorophenyl)methyl]amino] carbonyl]oxy]-1-[2-oxo-2-(2-thienyl)ethyl]-1-azoniabicyclo[2.2.2]octane bromide (CHF5407), a potent, long-acting, and selective muscarinic M3 receptor antagonist.

Villetti G, Pastore F, Bergamaschi M, Bassani F, Bolzoni PT, Battipaglia L, Amari G, Rizzi A, Delcanale M, Volta R, Cenacchi V, Cacciani F, Zaniboni M, Berti F, Rossoni G, Harrison S, Petrillo P, Santoro E, Scudellaro R, Mannini F, Geppetti PA, Razzetti R, Patacchini R, Civelli M.

J Pharmacol Exp Ther. 2010 Dec;335(3):622-35. doi: 10.1124/jpet.110.170035. Epub 2010 Aug 30.

PMID:
20805306
[PubMed - indexed for MEDLINE]
Free Article
4.

Discovery of novel 1-azoniabicyclo[2.2.2]octane muscarinic acetylcholine receptor antagonists.

Lainé DI, McCleland B, Thomas S, Neipp C, Underwood B, Dufour J, Widdowson KL, Palovich MR, Blaney FE, Foley JJ, Webb EF, Luttmann MA, Burman M, Belmonte K, Salmon M.

J Med Chem. 2009 Apr 23;52(8):2493-505. doi: 10.1021/jm801601v.

PMID:
19317446
[PubMed - indexed for MEDLINE]
5.

Inhalation by design: novel tertiary amine muscarinic M₃ receptor antagonists with slow off-rate binding kinetics for inhaled once-daily treatment of chronic obstructive pulmonary disease.

Glossop PA, Watson CA, Price DA, Bunnage ME, Middleton DS, Wood A, James K, Roberts D, Strang RS, Yeadon M, Perros-Huguet C, Clarke NP, Trevethick MA, Machin I, Stuart EF, Evans SM, Harrison AC, Fairman DA, Agoram B, Burrows JL, Feeder N, Fulton CK, Dillon BR, Entwistle DA, Spence FJ.

J Med Chem. 2011 Oct 13;54(19):6888-904. doi: 10.1021/jm200884j. Epub 2011 Sep 20.

PMID:
21870878
[PubMed - indexed for MEDLINE]
6.

Design and synthesis of novel sulfonamide-containing bradykinin hB2 receptor antagonists. 2. Synthesis and structure-activity relationships of alpha,alpha-cycloalkylglycine sulfonamides.

Fattori D, Rossi C, Fincham CI, Caciagli V, Catrambone F, D'Andrea P, Felicetti P, Gensini M, Marastoni E, Nannicini R, Paris M, Terracciano R, Bressan A, Giuliani S, Maggi CA, Meini S, Valenti C, Quartara L.

J Med Chem. 2007 Feb 8;50(3):550-65.

PMID:
17266207
[PubMed - indexed for MEDLINE]
7.

Design, synthesis, and structure-activity relationship of tropane muscarinic acetylcholine receptor antagonists.

Lainé DI, Wan Z, Yan H, Zhu C, Xie H, Fu W, Busch-Petersen J, Neipp C, Davis R, Widdowson KL, Blaney FE, Foley J, Bacon AM, Webb EF, Luttmann MA, Burman M, Sarau HM, Salmon M, Palovich MR, Belmonte K.

J Med Chem. 2009 Aug 27;52(16):5241-52. doi: 10.1021/jm900736e.

PMID:
19630384
[PubMed - indexed for MEDLINE]
8.

Selective antagonism activity of alkaloids from bulbs Fritillariae at muscarinic receptors: functional studies.

Lin BQ, Ji H, Li P, Jiang Y, Fang W.

Eur J Pharmacol. 2006 Dec 3;551(1-3):125-30. Epub 2006 Sep 9.

PMID:
17027747
[PubMed - indexed for MEDLINE]
9.

J-104129, a novel muscarinic M3 receptor antagonist with high selectivity for M3 over M2 receptors.

Mitsuya M, Mase T, Tsuchiya Y, Kawakami K, Hattori H, Kobayashi K, Ogino Y, Fujikawa T, Satoh A, Kimura T, Noguchi K, Ohtake N, Tomimoto K.

Bioorg Med Chem. 1999 Nov;7(11):2555-67.

PMID:
10632066
[PubMed - indexed for MEDLINE]
10.

Characterization of bencycloquidium bromide, a novel muscarinic M(3) receptor antagonist in guinea pig airways.

Jiang JX, Cao R, Deng WD, Jin F, Dong XW, Zhu Y, Chen XP, Xie YC, Bao MJ, Li FF, Xie QM.

Eur J Pharmacol. 2011 Mar 25;655(1-3):74-82. doi: 10.1016/j.ejphar.2011.01.017. Epub 2011 Jan 24.

PMID:
21272572
[PubMed - indexed for MEDLINE]
11.

Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinol esters as potent and long-acting muscarinic antagonists with potential for minimal systemic exposure after inhaled administration: identification of (3R)-3-{[hydroxy(di-2-thienyl)acetyl]oxy}-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane bromide (aclidinium bromide).

Prat M, Fernández D, Buil MA, Crespo MI, Casals G, Ferrer M, Tort L, Castro J, Monleón JM, Gavaldà A, Miralpeix M, Ramos I, Doménech T, Vilella D, Antón F, Huerta JM, Espinosa S, López M, Sentellas S, González M, Albertí J, Segarra V, Cárdenas A, Beleta J, Ryder H.

J Med Chem. 2009 Aug 27;52(16):5076-92. doi: 10.1021/jm900132z.

PMID:
19653626
[PubMed - indexed for MEDLINE]
12.

New 8-substituted xanthiene derivatives as potent bronchodilators.

Berk B, Akgün H, Erol K, Sirmagül B, Gao ZG, Jacobson KA.

Farmaco. 2005 Nov-Dec;60(11-12):974-80. Epub 2005 Oct 21.

PMID:
16243321
[PubMed - indexed for MEDLINE]
13.

Fluorescent styryl dyes FM1-43 and FM2-10 are muscarinic receptor antagonists: intravital visualization of receptor occupancy.

Mazzone SB, Mori N, Burman M, Palovich M, Belmonte KE, Canning BJ.

J Physiol. 2006 Aug 15;575(Pt 1):23-35. Epub 2006 May 25.

PMID:
16728454
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Synthesis and antimuscarinic properties of quinuclidin-3-yl 1,2,3,4-tetrahydroisoquinoline-2-carboxylate derivatives as novel muscarinic receptor antagonists.

Naito R, Yonetoku Y, Okamoto Y, Toyoshima A, Ikeda K, Takeuchi M.

J Med Chem. 2005 Oct 20;48(21):6597-606.

PMID:
16220976
[PubMed - indexed for MEDLINE]
15.

Rapacuronium preferentially antagonizes the function of M2 versus M3 muscarinic receptors in guinea pig airway smooth muscle.

Jooste E, Zhang Y, Emala CW.

Anesthesiology. 2005 Jan;102(1):117-24.

PMID:
15618795
[PubMed - indexed for MEDLINE]
Free Article
16.

A potent, long-acting, orally active (2R)-2-[(1R)-3, 3-difluorocyclopentyl]-2-hydroxy-2-phenylacetamide: novel muscarinic M(3) receptor antagonist with high selectivity for M(3) over M(2) receptors.

Mitsuya M, Kobayashi K, Kawakami K, Satoh A, Ogino Y, Kakikawa T, Ohtake N, Kimura T, Hirose H, Sato A, Numazawa T, Hasegawa T, Noguchi K, Mase T.

J Med Chem. 2000 Dec 28;43(26):5017-29.

PMID:
11150173
[PubMed - indexed for MEDLINE]
17.

Synthesis and antagonistic activity at muscarinic receptor subtypes of some derivatives of diphenidol.

Varoli L, Angeli P, Buccioni M, Burnelli S, Cavalli A, Marucci G, Recanatini M.

Farmaco. 2003 Sep;58(9):651-7.

PMID:
13679157
[PubMed - indexed for MEDLINE]
18.

Synthesis, affinity profile, and functional activity of muscarinic antagonists with a 1-methyl-2-(2,2-alkylaryl-1,3-oxathiolan-5-yl)pyrrolidine structure.

Dei S, Bellucci C, Buccioni M, Ferraroni M, Guandalini L, Manetti D, Martini E, Marucci G, Matucci R, Nesi M, Romanelli MN, Scapecchi S, Teodori E.

J Med Chem. 2007 Mar 22;50(6):1409-13. Epub 2007 Feb 17.

PMID:
17305327
[PubMed - indexed for MEDLINE]
19.

Pre-clinical and clinical pharmacology of selective muscarinic M3 receptor antagonists.

Wallis RM.

Life Sci. 1995;56(11-12):861-8.

PMID:
10188786
[PubMed - indexed for MEDLINE]
20.

Functional selectivity of muscarinic receptor antagonists for inhibition of M3-mediated phosphoinositide responses in guinea pig urinary bladder and submandibular salivary gland.

Nelson CP, Gupta P, Napier CM, Nahorski SR, Challiss RA.

J Pharmacol Exp Ther. 2004 Sep;310(3):1255-65. Epub 2004 May 12.

PMID:
15140916
[PubMed - indexed for MEDLINE]
Free Article

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