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Items: 1 to 20 of 159

1.

The C-type lectin receptors CLEC-2 and Dectin-1, but not DC-SIGN, signal via a novel YXXL-dependent signaling cascade.

Fuller GL, Williams JA, Tomlinson MG, Eble JA, Hanna SL, Pöhlmann S, Suzuki-Inoue K, Ozaki Y, Watson SP, Pearce AC.

J Biol Chem. 2007 Apr 27;282(17):12397-409. Epub 2007 Mar 5.

2.

G6b-B inhibits constitutive and agonist-induced signaling by glycoprotein VI and CLEC-2.

Mori J, Pearce AC, Spalton JC, Grygielska B, Eble JA, Tomlinson MG, Senis YA, Watson SP.

J Biol Chem. 2008 Dec 19;283(51):35419-27. doi: 10.1074/jbc.M806895200. Epub 2008 Oct 27.

3.

CLEC-2 activates Syk through dimerization.

Hughes CE, Pollitt AY, Mori J, Eble JA, Tomlinson MG, Hartwig JH, O'Callaghan CA, Fütterer K, Watson SP.

Blood. 2010 Apr 8;115(14):2947-55. doi: 10.1182/blood-2009-08-237834. Epub 2010 Feb 12.

4.

A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2.

Suzuki-Inoue K, Fuller GL, García A, Eble JA, Pöhlmann S, Inoue O, Gartner TK, Hughan SC, Pearce AC, Laing GD, Theakston RD, Schweighoffer E, Zitzmann N, Morita T, Tybulewicz VL, Ozaki Y, Watson SP.

Blood. 2006 Jan 15;107(2):542-9. Epub 2005 Sep 20.

5.

Syk-dependent phosphorylation of CLEC-2: a novel mechanism of hem-immunoreceptor tyrosine-based activation motif signaling.

Séverin S, Pollitt AY, Navarro-Nuñez L, Nash CA, Mourão-Sá D, Eble JA, Senis YA, Watson SP.

J Biol Chem. 2011 Feb 11;286(6):4107-16. doi: 10.1074/jbc.M110.167502. Epub 2010 Nov 22.

6.

Critical Role for an acidic amino acid region in platelet signaling by the HemITAM (hemi-immunoreceptor tyrosine-based activation motif) containing receptor CLEC-2 (C-type lectin receptor-2).

Hughes CE, Sinha U, Pandey A, Eble JA, O'Callaghan CA, Watson SP.

J Biol Chem. 2013 Feb 15;288(7):5127-35. doi: 10.1074/jbc.M112.411462. Epub 2012 Dec 21.

7.

Phosphorylation of CLEC-2 is dependent on lipid rafts, actin polymerization, secondary mediators, and Rac.

Pollitt AY, Grygielska B, Leblond B, Désiré L, Eble JA, Watson SP.

Blood. 2010 Apr 8;115(14):2938-46. doi: 10.1182/blood-2009-12-257212. Epub 2010 Feb 12.

8.

Distinct pathways regulate Syk protein activation downstream of immune tyrosine activation motif (ITAM) and hemITAM receptors in platelets.

Manne BK, Badolia R, Dangelmaier C, Eble JA, Ellmeier W, Kahn M, Kunapuli SP.

J Biol Chem. 2015 May 1;290(18):11557-68. doi: 10.1074/jbc.M114.629527. Epub 2015 Mar 12.

9.

Costimulation of dectin-1 and DC-SIGN triggers the arachidonic acid cascade in human monocyte-derived dendritic cells.

Valera I, Fernández N, Trinidad AG, Alonso S, Brown GD, Alonso A, Crespo MS.

J Immunol. 2008 Apr 15;180(8):5727-36.

10.

The novel Syk inhibitor R406 reveals mechanistic differences in the initiation of GPVI and CLEC-2 signaling in platelets.

Spalton JC, Mori J, Pollitt AY, Hughes CE, Eble JA, Watson SP.

J Thromb Haemost. 2009 Jul;7(7):1192-9. doi: 10.1111/j.1538-7836.2009.03451.x. Epub 2009 Apr 24.

11.

GPVI and CLEC-2 in hemostasis and vascular integrity.

Watson SP, Herbert JM, Pollitt AY.

J Thromb Haemost. 2010 Jul;8(7):1456-67. doi: 10.1111/j.1538-7836.2010.03875.x. Epub 2010 Mar 25. Review.

12.

Tyrosine phosphorylation of SLP-76 is downstream of Syk following stimulation of the collagen receptor in platelets.

Gross BS, Lee JR, Clements JL, Turner M, Tybulewicz VL, Findell PR, Koretzky GA, Watson SP.

J Biol Chem. 1999 Feb 26;274(9):5963-71.

13.

Syk and Src family kinases regulate C-type lectin receptor 2 (CLEC-2)-mediated clustering of podoplanin and platelet adhesion to lymphatic endothelial cells.

Pollitt AY, Poulter NS, Gitz E, Navarro-Nuñez L, Wang YJ, Hughes CE, Thomas SG, Nieswandt B, Douglas MR, Owen DM, Jackson DG, Dustin ML, Watson SP.

J Biol Chem. 2014 Dec 26;289(52):35695-710. doi: 10.1074/jbc.M114.584284. Epub 2014 Nov 3.

15.

Platelet adhesion to podoplanin under flow is mediated by the receptor CLEC-2 and stabilised by Src/Syk-dependent platelet signalling.

Navarro-Núñez L, Pollitt AY, Lowe K, Latif A, Nash GB, Watson SP.

Thromb Haemost. 2015 May;113(5):1109-20. doi: 10.1160/TH14-09-0762. Epub 2015 Feb 19.

PMID:
25694214
16.

Signaling of the ITK (interleukin 2-inducible T cell kinase)-SYK (spleen tyrosine kinase) fusion kinase is dependent on adapter SLP-76 and on the adapter function of the kinases SYK and ZAP70.

Hussain A, Mohammad DK, Gustafsson MO, Uslu M, Hamasy A, Nore BF, Mohamed AJ, Smith CI.

J Biol Chem. 2013 Mar 8;288(10):7338-50. doi: 10.1074/jbc.M112.374967. Epub 2013 Jan 4.

17.

CLEC-2 signaling via Syk in myeloid cells can regulate inflammatory responses.

Mourão-Sá D, Robinson MJ, Zelenay S, Sancho D, Chakravarty P, Larsen R, Plantinga M, Van Rooijen N, Soares MP, Lambrecht B, Reis e Sousa C.

Eur J Immunol. 2011 Oct;41(10):3040-53. doi: 10.1002/eji.201141641. Epub 2011 Aug 17.

18.

Novel platelet activation receptor CLEC-2: from discovery to prospects.

Suzuki-Inoue K, Inoue O, Ozaki Y.

J Thromb Haemost. 2011 Jul;9 Suppl 1:44-55. doi: 10.1111/j.1538-7836.2011.04335.x. Review.

19.

"Sweet talk": closing in on C type lectin signaling.

Meyer-Wentrup F, Cambi A, Adema GJ, Figdor CG.

Immunity. 2005 Apr;22(4):399-400.

20.

Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins.

Rogers NC, Slack EC, Edwards AD, Nolte MA, Schulz O, Schweighoffer E, Williams DL, Gordon S, Tybulewicz VL, Brown GD, Reis e Sousa C.

Immunity. 2005 Apr;22(4):507-17. Erratum in: Immunity. 2005 Jun;22(6):773-4.

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