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Results: 1 to 20 of 132

1.

Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance.

Holland WL, Brozinick JT, Wang LP, Hawkins ED, Sargent KM, Liu Y, Narra K, Hoehn KL, Knotts TA, Siesky A, Nelson DH, Karathanasis SK, Fontenot GK, Birnbaum MJ, Summers SA.

Cell Metab. 2007 Mar;5(3):167-79.

PMID:
17339025
[PubMed - indexed for MEDLINE]
Free Article
2.

Ceramides in insulin resistance and lipotoxicity.

Summers SA.

Prog Lipid Res. 2006 Jan;45(1):42-72. Epub 2005 Dec 19. Review.

PMID:
16445986
[PubMed - indexed for MEDLINE]
3.

Adipose tissue and ceramide biosynthesis in the pathogenesis of obesity.

Samad F, Badeanlou L, Shah C, Yang G.

Adv Exp Med Biol. 2011;721:67-86. doi: 10.1007/978-1-4614-0650-1_5. Review.

PMID:
21910083
[PubMed - indexed for MEDLINE]
4.

Metabolic implications of dietary trans-fatty acids.

Dorfman SE, Laurent D, Gounarides JS, Li X, Mullarkey TL, Rocheford EC, Sari-Sarraf F, Hirsch EA, Hughes TE, Commerford SR.

Obesity (Silver Spring). 2009 Jun;17(6):1200-7. doi: 10.1038/oby.2008.662. Epub 2009 Feb 19. Erratum in: Obesity (Silver Spring). 2009 Jul;17(7):1474.

PMID:
19584878
[PubMed - indexed for MEDLINE]
5.

Sphingolipids, insulin resistance, and metabolic disease: new insights from in vivo manipulation of sphingolipid metabolism.

Holland WL, Summers SA.

Endocr Rev. 2008 Jun;29(4):381-402. doi: 10.1210/er.2007-0025. Epub 2008 May 1. Review.

PMID:
18451260
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice.

Holland WL, Bikman BT, Wang LP, Yuguang G, Sargent KM, Bulchand S, Knotts TA, Shui G, Clegg DJ, Wenk MR, Pagliassotti MJ, Scherer PE, Summers SA.

J Clin Invest. 2011 May;121(5):1858-70. doi: 10.1172/JCI43378. Epub 2011 Apr 1.

PMID:
21490391
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Sphingolipids and insulin resistance: the five Ws.

Summers SA.

Curr Opin Lipidol. 2010 Apr;21(2):128-35. doi: 10.1097/MOL.0b013e3283373b66. Review.

PMID:
20216312
[PubMed - indexed for MEDLINE]
8.

The path to insulin resistance: paved with ceramides?

Zierath JR.

Cell Metab. 2007 Mar;5(3):161-3.

PMID:
17339023
[PubMed - indexed for MEDLINE]
Free Article
9.

Excess lipid availability increases mitochondrial fatty acid oxidative capacity in muscle: evidence against a role for reduced fatty acid oxidation in lipid-induced insulin resistance in rodents.

Turner N, Bruce CR, Beale SM, Hoehn KL, So T, Rolph MS, Cooney GJ.

Diabetes. 2007 Aug;56(8):2085-92. Epub 2007 May 22.

PMID:
17519422
[PubMed - indexed for MEDLINE]
Free Article
10.

A ceramide-centric view of insulin resistance.

Chavez JA, Summers SA.

Cell Metab. 2012 May 2;15(5):585-94. doi: 10.1016/j.cmet.2012.04.002.

PMID:
22560211
[PubMed - indexed for MEDLINE]
Free Article
11.

Saturated and unsaturated fat induce hepatic insulin resistance independently of TLR-4 signaling and ceramide synthesis in vivo.

Galbo T, Perry RJ, Jurczak MJ, Camporez JP, Alves TC, Kahn M, Guigni BA, Serr J, Zhang D, Bhanot S, Samuel VT, Shulman GI.

Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12780-5. doi: 10.1073/pnas.1311176110. Epub 2013 Jul 9.

PMID:
23840067
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Sphingolipid metabolism and analysis in metabolic disease.

Brice SE, Cowart LA.

Adv Exp Med Biol. 2011;721:1-17. doi: 10.1007/978-1-4614-0650-1_1. Review.

PMID:
21910079
[PubMed - indexed for MEDLINE]
13.

Effect of gender on lipid-induced insulin resistance in obese subjects.

Vistisen B, Hellgren LI, Vadset T, Scheede-Bergdahl C, Helge JW, Dela F, Stallknecht B.

Eur J Endocrinol. 2008 Jan;158(1):61-8. doi: 10.1530/EJE-07-0493.

PMID:
18166818
[PubMed - indexed for MEDLINE]
Free Article
14.

Protection from high fat diet-induced increase in ceramide in mice lacking plasminogen activator inhibitor 1.

Shah C, Yang G, Lee I, Bielawski J, Hannun YA, Samad F.

J Biol Chem. 2008 May 16;283(20):13538-48. doi: 10.1074/jbc.M709950200. Epub 2008 Mar 22.

PMID:
18359942
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Sphingolipids: agents provocateurs in the pathogenesis of insulin resistance.

Lipina C, Hundal HS.

Diabetologia. 2011 Jul;54(7):1596-607. doi: 10.1007/s00125-011-2127-3. Epub 2011 Apr 6. Review. Erratum in: Diabetologia. 2011 Nov;54(11):2969.

PMID:
21468641
[PubMed - indexed for MEDLINE]
16.

A role for sphingolipids in producing the common features of type 2 diabetes, metabolic syndrome X, and Cushing's syndrome.

Summers SA, Nelson DH.

Diabetes. 2005 Mar;54(3):591-602. Review.

PMID:
15734832
[PubMed - indexed for MEDLINE]
Free Article
17.

Understanding insulin resistance. What are the clinical implications?

Sivitz WI.

Postgrad Med. 2004 Jul;116(1):41-8. Review.

PMID:
15274287
[PubMed - indexed for MEDLINE]
18.

Myostatin inhibition in muscle, but not adipose tissue, decreases fat mass and improves insulin sensitivity.

Guo T, Jou W, Chanturiya T, Portas J, Gavrilova O, McPherron AC.

PLoS One. 2009;4(3):e4937. doi: 10.1371/journal.pone.0004937. Epub 2009 Mar 19.

PMID:
19295913
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Increasing the fat-to-carbohydrate ratio in a high-fat diet prevents the development of obesity but not a prediabetic state in rats.

Sinitskaya N, Gourmelen S, Schuster-Klein C, Guardiola-Lemaitre B, PĂ©vet P, Challet E.

Clin Sci (Lond). 2007 Nov;113(10):417-25.

PMID:
17608620
[PubMed - indexed for MEDLINE]
Free Article
20.

The twists and turns of sphingolipid pathway in glucose regulation.

Deevska GM, Nikolova-Karakashian MN.

Biochimie. 2011 Jan;93(1):32-8. doi: 10.1016/j.biochi.2010.05.016. Epub 2010 May 31. Review.

PMID:
20561942
[PubMed - indexed for MEDLINE]
Free PMC Article
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