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Items: 1 to 20 of 383

1.

Prenyloxyphenylpropanoids as novel lead compounds for the selective inhibition of geranylgeranyl transferase I.

Epifano F, Curini M, Genovese S, Blaskovich M, Hamilton A, Sebti SM.

Bioorg Med Chem Lett. 2007 May 1;17(9):2639-42. Epub 2007 Feb 2. Erratum in: Bioorg Med Chem Lett. 2007 Oct 1;17(19):5492.

PMID:
17314046
2.

Clavaric acid and steroidal analogues as Ras- and FPP-directed inhibitors of human farnesyl-protein transferase.

Lingham RB, Silverman KC, Jayasuriya H, Kim BM, Amo SE, Wilson FR, Rew DJ, Schaber MD, Bergstrom JD, Koblan KS, Graham SL, Kohl NE, Gibbs JB, Singh SB.

J Med Chem. 1998 Nov 5;41(23):4492-501.

PMID:
9804689
3.

Stable analogues of geranylgeranyl diphosphate possessing improved geranylgeranyl versus farnesyl protein transferase inhibitory selectivity.

Minutolo F, Bertini S, Betti L, Danesi R, Gervasi G, Giannaccini G, Papi C, Placanica G, Barontini S, Rapposelli S, Macchia M.

Bioorg Med Chem Lett. 2003 Dec 15;13(24):4405-8.

PMID:
14643335
4.

Non-thiol farnesyltransferase inhibitors: FTase-inhibition and cellular activity of benzophenone-based bisubstrate analogue farnesyltransferase inhibitors.

Mitsch A, Bergemann S, Gust R, Sattler I, Schlitzer M.

Arch Pharm (Weinheim). 2003 Jul;336(4-5):242-50.

PMID:
12916059
5.

Structure-activity relationship of 3-substituted N-(pyridinylacetyl)-4- (8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene )- piperidine inhibitors of farnesyl-protein transferase: design and synthesis of in vivo active antitumor compounds.

Njoroge FG, Vibulbhan B, Rane DF, Bishop WR, Petrin J, Patton R, Bryant MS, Chen KJ, Nomeir AA, Lin CC, Liu M, King I, Chen J, Lee S, Yaremko B, Dell J, Lipari P, Malkowski M, Li Z, Catino J, Doll RJ, Girijavallabhan V, Ganguly AK.

J Med Chem. 1997 Dec 19;40(26):4290-301.

PMID:
9435898
6.

Synthesis and evaluation of hydroxyproline-derived isoprenyltransferase inhibitors.

O'Connell CE, Ackermann K, Rowell CA, Garcia AM, Lewis MD, Schwartz CE.

Bioorg Med Chem Lett. 1999 Jul 19;9(14):2095-100.

PMID:
10450988
7.

Kampanols: novel Ras farnesyl-protein transferase inhibitors from Stachybotrys kampalensis.

Singh SB, Zink DL, Williams M, Polishook JD, Sanchez M, Silverman KC, Lingham RB.

Bioorg Med Chem Lett. 1998 Aug 18;8(16):2071-6.

PMID:
9873488
8.

A novel class of highly potent, selective, and non-peptidic inhibitor of Ras farnesyltransferase (FTase).

Lee H, Lee J, Lee S, Shin Y, Jung W, Kim JH, Park K, Kim K, Cho HS, Ro S, Lee S, Jeong SW, Choi T, Chung HH, Koh JS.

Bioorg Med Chem Lett. 2001 Dec 3;11(23):3069-72.

PMID:
11714612
9.

Phosphonomethylphosphorylmethyl(oxy)-analogues of geranylgeranyl diphosphate as stable and selective geranylgeranyl protein transferase inhibitors.

Minutolo F, Antonello M, Barontini S, Bertini S, Betti L, Danesi R, Gervasi G, Giannaccini G, Papi C, Placanica G, Rapposelli S, Macchia M.

Farmaco. 2004 Nov;59(11):887-92.

PMID:
15544793
10.

Synthesis of stable analogues of geranylgeranyl diphosphate possessing a (Z,E,E)-geranylgeranyl side chain, docking analysis, and biological assays for prenyl protein transferase inhibition.

Minutolo F, Bertini S, Betti L, Danesi R, Gervasi G, Giannaccini G, Martinelli A, Papini AM, Peroni E, Placanica G, Rapposelli S, Tuccinardi T, Macchia M.

ChemMedChem. 2006 Feb;1(2):218-24.

PMID:
16892354
11.

Novel 2-aminobenzothiazoles as selective neuronal nitric oxide synthase inhibitors.

Patman J, Bhardwaj N, Ramnauth J, Annedi SC, Renton P, Maddaford SP, Rakhit S, Andrews JS.

Bioorg Med Chem Lett. 2007 May 1;17(9):2540-4. Epub 2007 Feb 8.

PMID:
17317165
12.

Novel limonene phosphonate and farnesyl diphosphate analogues: design, synthesis, and evaluation as potential protein-farnesyl transferase inhibitors.

Eummer JT, Gibbs BS, Zahn TJ, Sebolt-Leopold JS, Gibbs RA.

Bioorg Med Chem. 1999 Feb;7(2):241-50.

PMID:
10218815
13.

Inhibitors of protein: geranylgeranyl transferases.

El Oualid F, Cohen LH, van der Marel GA, Overhand M.

Curr Med Chem. 2006;13(20):2385-427. Review.

PMID:
16918362
14.

Identification of novel inhibitors of extracellular signal-regulated kinase 2 based on the structure-based virtual screening.

Park H, Bahn YJ, Jeong DG, Woo EJ, Kwon JS, Ryu SE.

Bioorg Med Chem Lett. 2008 Oct 15;18(20):5372-6. doi: 10.1016/j.bmcl.2008.09.058. Epub 2008 Sep 18.

PMID:
18835158
15.

Synthesis and biological evaluation of pyrido[3',2':4,5]furo[3,2-d]pyrimidine derivatives as novel PI3 kinase p110alpha inhibitors.

Hayakawa M, Kaizawa H, Moritomo H, Koizumi T, Ohishi T, Yamano M, Okada M, Ohta M, Tsukamoto S, Raynaud FI, Workman P, Waterfield MD, Parker P.

Bioorg Med Chem Lett. 2007 May 1;17(9):2438-42. Epub 2007 Feb 15.

PMID:
17339109
16.

Stable propylphosphonic acid analogues of geranylgeranyl diphosphate possessing inhibitory activity on geranylgeranyl protein transferase.

Minutolo F, Asso V, Bertini S, Betti L, Gervasi G, Ghilardi E, Giannaccini G, Placanica G, Prota G, Rapposelli S, Macchia M.

Farmaco. 2004 Nov;59(11):857-61.

PMID:
15544789
17.

Synthesis and evaluation of GGPP geometric isomers: divergent substrate specificities of FTase and GGTase I.

Zahn TJ, Whitney J, Weinbaum C, Gibbs RA.

Bioorg Med Chem Lett. 2001 Jun 18;11(12):1605-8.

PMID:
11412990
18.

Substituted azoloquinolines and -quinazolines as new potent farnesyl protein transferase inhibitors.

Angibaud P, Bourdrez X, End DW, Freyne E, Janicot M, Lezouret P, Ligny Y, Mannens G, Damsch S, Mevellec L, Meyer C, Muller P, Pilatte I, Poncelet V, Roux B, Smets G, Van Dun J, Van Remoortere P, Venet M, Wouters W.

Bioorg Med Chem Lett. 2003 Dec 15;13(24):4365-9.

PMID:
14643327
19.

Design and synthesis of piperidine farnesyltransferase inhibitors with reduced glucuronidation potential.

Tanaka R, Rubio A, Harn NK, Gernert D, Grese TA, Eishima J, Hara M, Yoda N, Ohashi R, Kuwabara T, Soga S, Akinaga S, Nara S, Kanda Y.

Bioorg Med Chem. 2007 Feb 1;15(3):1363-82. Epub 2006 Nov 9.

PMID:
17127066
20.

Synthesis of N,N'-disubstituted 3-aminobenzo[c] and [d]azepin-2-ones as potent and specific farnesyl transferase inhibitors.

Le Diguarher T, Ortuno JC, Shanks D, Guilbaud N, Pierré A, Raimbaud E, Fauchère JL, Hickman JA, Tucker GC, Casara PJ.

Bioorg Med Chem Lett. 2004 Feb 9;14(3):767-71.

PMID:
14741286
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