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The contact allergen nickel triggers a unique inflammatory and proangiogenic gene expression pattern via activation of NF-kappaB and hypoxia-inducible factor-1alpha.

Viemann D, Schmidt M, Tenbrock K, Schmid S, Müller V, Klimmek K, Ludwig S, Roth J, Goebeler M.

J Immunol. 2007 Mar 1;178(5):3198-207.


Inflammatory stimulation and hypoxia cooperatively activate HIF-1{alpha} in bronchial epithelial cells: involvement of PI3K and NF-{kappa}B.

Jiang H, Zhu YS, Xu H, Sun Y, Li QF.

Am J Physiol Lung Cell Mol Physiol. 2010 May;298(5):L660-9. doi: 10.1152/ajplung.00394.2009. Epub 2010 Feb 5.


An intact canonical NF-κB pathway is required for inflammatory gene expression in response to hypoxia.

Fitzpatrick SF, Tambuwala MM, Bruning U, Schaible B, Scholz CC, Byrne A, O'Connor A, Gallagher WM, Lenihan CR, Garvey JF, Howell K, Fallon PG, Cummins EP, Taylor CT.

J Immunol. 2011 Jan 15;186(2):1091-6. doi: 10.4049/jimmunol.1002256. Epub 2010 Dec 13.


The involvement of hypoxia-inducible transcription factor-1-dependent pathway in nickel carcinogenesis.

Salnikow K, Davidson T, Zhang Q, Chen LC, Su W, Costa M.

Cancer Res. 2003 Jul 1;63(13):3524-30.


Transcriptional profiling of IKK2/NF-kappa B- and p38 MAP kinase-dependent gene expression in TNF-alpha-stimulated primary human endothelial cells.

Viemann D, Goebeler M, Schmid S, Klimmek K, Sorg C, Ludwig S, Roth J.

Blood. 2004 May 1;103(9):3365-73. Epub 2004 Jan 8.


Candida albicans triggers activation of distinct signaling pathways to establish a proinflammatory gene expression program in primary human endothelial cells.

Müller V, Viemann D, Schmidt M, Endres N, Ludwig S, Leverkus M, Roth J, Goebeler M.

J Immunol. 2007 Dec 15;179(12):8435-45.


Regulation of cytokine-induced HIF-1alpha expression in rheumatoid synovial fibroblasts.

Westra J, Brouwer E, Bos R, Posthumus MD, Doornbos-van der Meer B, Kallenberg CG, Limburg PC.

Ann N Y Acad Sci. 2007 Jun;1108:340-8.


IL-17 stimulates MMP-1 expression in primary human cardiac fibroblasts via p38 MAPK- and ERK1/2-dependent C/EBP-beta , NF-kappaB, and AP-1 activation.

Cortez DM, Feldman MD, Mummidi S, Valente AJ, Steffensen B, Vincenti M, Barnes JL, Chandrasekar B.

Am J Physiol Heart Circ Physiol. 2007 Dec;293(6):H3356-65. Epub 2007 Oct 5.


Abrogation of NF-κB signaling in human neutrophils induces neutrophil survival through sustained p38-MAPK activation.

Langereis JD, Raaijmakers HA, Ulfman LH, Koenderman L.

J Leukoc Biol. 2010 Oct;88(4):655-64. doi: 10.1189/jlb.0809544. Epub 2010 Jun 23.


The NF-kappaB, p38 MAPK and STAT1 pathways differentially regulate the dsRNA-mediated innate immune responses of epidermal keratinocytes.

Dai X, Sayama K, Tohyama M, Shirakata Y, Yang L, Hirakawa S, Tokumaru S, Hashimoto K.

Int Immunol. 2008 Jul;20(7):901-9. doi: 10.1093/intimm/dxn048. Epub 2008 May 19.


Hypoxia up-regulates hypoxia-inducible factor-1alpha transcription by involving phosphatidylinositol 3-kinase and nuclear factor kappaB in pulmonary artery smooth muscle cells.

Belaiba RS, Bonello S, Zähringer C, Schmidt S, Hess J, Kietzmann T, Görlach A.

Mol Biol Cell. 2007 Dec;18(12):4691-7. Epub 2007 Sep 26.


HIF-1alpha expression in response to lipopolysaccaride mediates induction of hepatic inflammatory cytokine TNFalpha.

Kim HY, Kim YH, Nam BH, Kong HJ, Kim HH, Kim YJ, An WG, Cheong J.

Exp Cell Res. 2007 May 15;313(9):1866-76. Epub 2007 Mar 20.


Salicylideneamino-2-thiophenol inhibits inflammatory mediator genes (RANTES, MCP-1, IL-8 and HIF-1alpha) expression induced by tert-butyl hydroperoxide via MAPK pathways in rat peritoneal macrophages.

Chung J, Lee HS, Chung HY, Yoon TR, Kim HK.

Biotechnol Lett. 2008 Sep;30(9):1553-8. doi: 10.1007/s10529-008-9744-z. Epub 2008 May 14.


Global gene expression analysis of ERK5 and ERK1/2 signaling reveals a role for HIF-1 in ERK5-mediated responses.

Schweppe RE, Cheung TH, Ahn NG.

J Biol Chem. 2006 Jul 28;281(30):20993-1003. Epub 2006 May 30.


Induction of nuclear factor-kappaB and its downstream genes by TNF-alpha and IL-1beta has a pro-apoptotic role in pancreatic beta cells.

Ortis F, Pirot P, Naamane N, Kreins AY, Rasschaert J, Moore F, Théâtre E, Verhaeghe C, Magnusson NE, Chariot A, Orntoft TF, Eizirik DL.

Diabetologia. 2008 Jul;51(7):1213-25. doi: 10.1007/s00125-008-0999-7. Epub 2008 May 8.


The role of hypoxia-inducible signaling pathway in nickel carcinogenesis.

Salnikow K, Davidson T, Costa M.

Environ Health Perspect. 2002 Oct;110 Suppl 5:831-4.


The specific contribution of hypoxia-inducible factor-2alpha to hypoxic gene expression in vitro is limited and modulated by cell type-specific and exogenous factors.

Warnecke C, Weidemann A, Volke M, Schietke R, Wu X, Knaup KX, Hackenbeck T, Bernhardt W, Willam C, Eckardt KU, Wiesener MS.

Exp Cell Res. 2008 Jun 10;314(10):2016-27. doi: 10.1016/j.yexcr.2008.03.003. Epub 2008 Mar 18.


Tachykinin-1 receptor stimulates proinflammatory gene expression in lung epithelial cells through activation of NF-kappaB via a G(q)-dependent pathway.

Williams R, Zou X, Hoyle GW.

Am J Physiol Lung Cell Mol Physiol. 2007 Feb;292(2):L430-7. Epub 2006 Oct 13.


Hypoxia-inducible factor (HIF) 1alpha accumulation and HIF target gene expression are impaired after induction of endotoxin tolerance.

Frede S, Stockmann C, Winning S, Freitag P, Fandrey J.

J Immunol. 2009 May 15;182(10):6470-6. doi: 10.4049/jimmunol.0802378.

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