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Results: 1 to 20 of 160

1.

Synthesis of bisubstrate inhibitors of porphobilinogen synthase from Pseudomonas aeruginosa.

Gacond S, Frère F, Nentwich M, Faurite JP, Frankenberg-Dinkel N, Neier R.

Chem Biodivers. 2007 Feb;4(2):189-202.

PMID:
17311232
[PubMed - indexed for MEDLINE]
2.

Structure of porphobilinogen synthase from Pseudomonas aeruginosa in complex with 5-fluorolevulinic acid suggests a double Schiff base mechanism.

Frère F, Schubert WD, Stauffer F, Frankenberg N, Neier R, Jahn D, Heinz DW.

J Mol Biol. 2002 Jul 5;320(2):237-47.

PMID:
12079382
[PubMed - indexed for MEDLINE]
3.

Production, purification, and characterization of a Mg2+-responsive porphobilinogen synthase from Pseudomonas aeruginosa.

Frankenberg N, Heinz DW, Jahn D.

Biochemistry. 1999 Oct 19;38(42):13968-75.

PMID:
10529243
[PubMed - indexed for MEDLINE]
4.

High resolution crystal structure of a Mg2+-dependent porphobilinogen synthase.

Frankenberg N, Erskine PT, Cooper JB, Shoolingin-Jordan PM, Jahn D, Heinz DW.

J Mol Biol. 1999 Jun 11;289(3):591-602.

PMID:
10356331
[PubMed - indexed for MEDLINE]
5.

Probing the active site of Pseudomonas aeruginosa porphobilinogen synthase using newly developed inhibitors.

Frère F, Nentwich M, Gacond S, Heinz DW, Neier R, Frankenberg-Dinkel N.

Biochemistry. 2006 Jul 11;45(27):8243-53.

PMID:
16819823
[PubMed - indexed for MEDLINE]
6.

Species-specific inhibition of porphobilinogen synthase by 4-oxosebacic acid.

Jaffe EK, Kervinen J, Martins J, Stauffer F, Neier R, Wlodawer A, Zdanov A.

J Biol Chem. 2002 May 31;277(22):19792-9. Epub 2002 Mar 21.

PMID:
11909869
[PubMed - indexed for MEDLINE]
Free Article
7.

5-Chlorolevulinate modification of porphobilinogen synthase identifies a potential role for the catalytic zinc.

Jaffe EK, Abrams WR, Kaempfen HX, Harris KA Jr.

Biochemistry. 1992 Feb 25;31(7):2113-23.

PMID:
1346974
[PubMed - indexed for MEDLINE]
8.

Mechanistic basis for suicide inactivation of porphobilinogen synthase by 4,7-dioxosebacic acid, an inhibitor that shows dramatic species selectivity.

Kervinen J, Jaffe EK, Stauffer F, Neier R, Wlodawer A, Zdanov A.

Biochemistry. 2001 Jul 27;40(28):8227-36.

PMID:
11444968
[PubMed - indexed for MEDLINE]
9.

Structure of the heme biosynthetic Pseudomonas aeruginosa porphobilinogen synthase in complex with the antibiotic alaremycin.

Heinemann IU, Schulz C, Schubert WD, Heinz DW, Wang YG, Kobayashi Y, Awa Y, Wachi M, Jahn D, Jahn M.

Antimicrob Agents Chemother. 2010 Jan;54(1):267-72. doi: 10.1128/AAC.00553-09. Epub 2009 Oct 12.

PMID:
19822707
[PubMed - indexed for MEDLINE]
Free PMC Article
10.
11.

Pseudomonas aeruginosa contains a novel type V porphobilinogen synthase with no required catalytic metal ions.

Frankenberg N, Jahn D, Jaffe EK.

Biochemistry. 1999 Oct 19;38(42):13976-82.

PMID:
10529244
[PubMed - indexed for MEDLINE]
12.

Inhibition of Escherichia coli porphobilinogen synthase using analogs of postulated intermediates.

Jarret C, Stauffer F, Henz ME, Marty M, Lüönd RM, Bobálová J, Schürmann P, Neier R.

Chem Biol. 2000 Mar;7(3):185-96.

PMID:
10712932
[PubMed - indexed for MEDLINE]
Free Article
13.

On the formation of the mixed pyrrole catalysed by porphobilinogen synthase from Rhodobacter spheroides.

Lüönd RM, Neier R.

Biochim Biophys Acta. 1996 Feb 9;1289(1):83-6.

PMID:
8605237
[PubMed - indexed for MEDLINE]
14.

Tracking the evolution of porphobilinogen synthase metal dependence in vitro.

Frère F, Reents H, Schubert WD, Heinz DW, Jahn D.

J Mol Biol. 2005 Feb 4;345(5):1059-70. Epub 2004 Dec 21.

PMID:
15644204
[PubMed - indexed for MEDLINE]
15.

5-Chloro[1,4-13C]levulinic acid modification of mammalian and bacterial porphobilinogen synthase suggests an active site containing two Zn(II).

Jaffe EK, Volin M, Myers CB, Abrams WR.

Biochemistry. 1994 Sep 27;33(38):11554-62.

PMID:
7918369
[PubMed - indexed for MEDLINE]
16.

Mechanistic implications of mutations to the active site lysine of porphobilinogen synthase.

Mitchell LW, Volin M, Martins J, Jaffe EK.

J Biol Chem. 2001 Jan 12;276(2):1538-44.

PMID:
11032841
[PubMed - indexed for MEDLINE]
Free Article
17.

Probing the active site of rat porphobilinogen synthase using newly developed inhibitors.

Li N, Chu X, Liu X, Li D.

Bioorg Chem. 2009 Feb;37(1):33-40. doi: 10.1016/j.bioorg.2008.11.001. Epub 2008 Dec 17.

PMID:
19095280
[PubMed - indexed for MEDLINE]
18.

The porphobilinogen synthase catalyzed reaction mechanism.

Jaffe EK.

Bioorg Chem. 2004 Oct;32(5):316-25. Review.

PMID:
15381398
[PubMed - indexed for MEDLINE]
19.

Porphobilinogen synthase, the first source of heme's asymmetry.

Jaffe EK.

J Bioenerg Biomembr. 1995 Apr;27(2):169-79. Review.

PMID:
7592564
[PubMed - indexed for MEDLINE]
20.

wALADin benzimidazoles differentially modulate the function of porphobilinogen synthase orthologs.

Lentz CS, Halls VS, Hannam JS, Strassel S, Lawrence SH, Jaffe EK, Famulok M, Hoerauf A, Pfarr KM.

J Med Chem. 2014 Mar 27;57(6):2498-510. doi: 10.1021/jm401785n. Epub 2014 Feb 25.

PMID:
24568185
[PubMed - indexed for MEDLINE]

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