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Results: 1 to 20 of 462

1.

In vitro and in vivo profiling of CHF5022 and CHF5074 Two beta-amyloid1-42 lowering agents.

Imbimbo BP, Del Giudice E, Cenacchi V, Volta R, Villetti G, Facchinetti F, Riccardi B, Puccini P, Moretto N, Grassi F, Ottonello S, Leon A.

Pharmacol Res. 2007 Apr;55(4):318-28. Epub 2007 Jan 16.

PMID:
17292621
[PubMed - indexed for MEDLINE]
2.

1-(3',4'-Dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid (CHF5074), a novel gamma-secretase modulator, reduces brain beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease without causing peripheral toxicity.

Imbimbo BP, Del Giudice E, Colavito D, D'Arrigo A, Dalle Carbonare M, Villetti G, Facchinetti F, Volta R, Pietrini V, Baroc MF, Serneels L, De Strooper B, Leon A.

J Pharmacol Exp Ther. 2007 Dec;323(3):822-30. Epub 2007 Sep 25.

PMID:
17895400
[PubMed - indexed for MEDLINE]
Free Article
3.

Selective inhibition of Abeta42 production by NSAID R-enantiomers.

Morihara T, Chu T, Ubeda O, Beech W, Cole GM.

J Neurochem. 2002 Nov;83(4):1009-12.

PMID:
12421374
[PubMed - indexed for MEDLINE]
4.

CHF5074, a novel gamma-secretase modulator, attenuates brain beta-amyloid pathology and learning deficit in a mouse model of Alzheimer's disease.

Imbimbo BP, Hutter-Paier B, Villetti G, Facchinetti F, Cenacchi V, Volta R, Lanzillotta A, Pizzi M, Windisch M.

Br J Pharmacol. 2009 Mar;156(6):982-93. doi: 10.1111/j.1476-5381.2008.00097.x.

PMID:
19239474
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice.

Kukar T, Prescott S, Eriksen JL, Holloway V, Murphy MP, Koo EH, Golde TE, Nicolle MM.

BMC Neurosci. 2007 Jul 24;8:54.

PMID:
17650315
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion.

Peretto I, Radaelli S, Parini C, Zandi M, Raveglia LF, Dondio G, Fontanella L, Misiano P, Bigogno C, Rizzi A, Riccardi B, Biscaioli M, Marchetti S, Puccini P, Catinella S, Rondelli I, Cenacchi V, Bolzoni PT, Caruso P, Villetti G, Facchinetti F, Del Giudice E, Moretto N, Imbimbo BP.

J Med Chem. 2005 Sep 8;48(18):5705-20.

PMID:
16134939
[PubMed - indexed for MEDLINE]
7.

Multi-target action of the novel anti-Alzheimer compound CHF5074: in vivo study of long term treatment in Tg2576 mice.

Sivilia S, Lorenzini L, Giuliani A, Gusciglio M, Fernandez M, Baldassarro VA, Mangano C, Ferraro L, Pietrini V, Baroc MF, Viscomi AR, Ottonello S, Villetti G, Imbimbo BP, Calzà L, Giardino L.

BMC Neurosci. 2013 Apr 5;14:44. doi: 10.1186/1471-2202-14-44.

PMID:
23560952
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity.

Weggen S, Eriksen JL, Das P, Sagi SA, Wang R, Pietrzik CU, Findlay KA, Smith TE, Murphy MP, Bulter T, Kang DE, Marquez-Sterling N, Golde TE, Koo EH.

Nature. 2001 Nov 8;414(6860):212-6.

PMID:
11700559
[PubMed - indexed for MEDLINE]
9.

The geminal dimethyl analogue of Flurbiprofen as a novel Abeta42 inhibitor and potential Alzheimer's disease modifying agent.

Stock N, Munoz B, Wrigley JD, Shearman MS, Beher D, Peachey J, Williamson TL, Bain G, Chen W, Jiang X, St-Jacques R, Prasit P.

Bioorg Med Chem Lett. 2006 Apr 15;16(8):2219-23. Epub 2006 Feb 7.

PMID:
16455248
[PubMed - indexed for MEDLINE]
10.

NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo.

Eriksen JL, Sagi SA, Smith TE, Weggen S, Das P, McLendon DC, Ozols VV, Jessing KW, Zavitz KH, Koo EH, Golde TE.

J Clin Invest. 2003 Aug;112(3):440-9.

PMID:
12897211
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

The γ-secretase modulator CHF5074 reduces the accumulation of native hyperphosphorylated tau in a transgenic mouse model of Alzheimer's disease.

Lanzillotta A, Sarnico I, Benarese M, Branca C, Baiguera C, Hutter-Paier B, Windisch M, Spano P, Imbimbo BP, Pizzi M.

J Mol Neurosci. 2011 Sep;45(1):22-31. doi: 10.1007/s12031-010-9482-2. Epub 2010 Dec 22.

PMID:
21181298
[PubMed - indexed for MEDLINE]
12.

Microglial activation and beta -amyloid deposit reduction caused by a nitric oxide-releasing nonsteroidal anti-inflammatory drug in amyloid precursor protein plus presenilin-1 transgenic mice.

Jantzen PT, Connor KE, DiCarlo G, Wenk GL, Wallace JL, Rojiani AM, Coppola D, Morgan D, Gordon MN.

J Neurosci. 2002 Mar 15;22(6):2246-54.

PMID:
11896164
[PubMed - indexed for MEDLINE]
Free Article
13.

Modulation of beta-amyloid metabolism by non-steroidal anti-inflammatory drugs in neuronal cell cultures.

Gasparini L, Rusconi L, Xu H, del Soldato P, Ongini E.

J Neurochem. 2004 Jan;88(2):337-48.

PMID:
14690522
[PubMed - indexed for MEDLINE]
14.

CHF5074, a novel gamma-secretase modulator, restores hippocampal neurogenesis potential and reverses contextual memory deficit in a transgenic mouse model of Alzheimer's disease.

Imbimbo BP, Giardino L, Sivilia S, Giuliani A, Gusciglio M, Pietrini V, Del Giudice E, D'Arrigo A, Leon A, Villetti G, Calzà L.

J Alzheimers Dis. 2010;20(1):159-73. doi: 10.3233/JAD-2010-1366.

PMID:
20164581
[PubMed - indexed for MEDLINE]
16.

The γ-secretase modulator CHF5074 restores memory and hippocampal synaptic plasticity in plaque-free Tg2576 mice.

Balducci C, Mehdawy B, Mare L, Giuliani A, Lorenzini L, Sivilia S, Giardino L, Calzà L, Lanzillotta A, Sarnico I, Pizzi M, Usiello A, Viscomi AR, Ottonello S, Villetti G, Imbimbo BP, Nisticò G, Forloni G, Nisticò R.

J Alzheimers Dis. 2011;24(4):799-816. doi: 10.3233/JAD-2011-101839.

PMID:
21321397
[PubMed - indexed for MEDLINE]
17.

Safety, tolerability, pharmacokinetics, and Abeta levels after short-term administration of R-flurbiprofen in healthy elderly individuals.

Galasko DR, Graff-Radford N, May S, Hendrix S, Cottrell BA, Sagi SA, Mather G, Laughlin M, Zavitz KH, Swabb E, Golde TE, Murphy MP, Koo EH.

Alzheimer Dis Assoc Disord. 2007 Oct-Dec;21(4):292-9.

PMID:
18090435
[PubMed - indexed for MEDLINE]
18.

Anti-inflammatory drug therapy alters beta-amyloid processing and deposition in an animal model of Alzheimer's disease.

Yan Q, Zhang J, Liu H, Babu-Khan S, Vassar R, Biere AL, Citron M, Landreth G.

J Neurosci. 2003 Aug 20;23(20):7504-9.

PMID:
12930788
[PubMed - indexed for MEDLINE]
Free Article
19.

Inhibitors of Rho-kinase modulate amyloid-beta (Abeta) secretion but lack selectivity for Abeta42.

Leuchtenberger S, Kummer MP, Kukar T, Czirr E, Teusch N, Sagi SA, Berdeaux R, Pietrzik CU, Ladd TB, Golde TE, Koo EH, Weggen S.

J Neurochem. 2006 Jan;96(2):355-65. Epub 2005 Nov 21.

PMID:
16300630
[PubMed - indexed for MEDLINE]
20.

Selective modulation of amyloid-beta peptide degradation by flurbiprofen, fenofibrate, and related compounds regulates Abeta levels.

Abdul-Hay SO, Edirisinghe P, Thatcher GR.

J Neurochem. 2009 Nov;111(3):683-95. doi: 10.1111/j.1471-4159.2009.06355.x. Epub 2009 Aug 22.

PMID:
19702658
[PubMed - indexed for MEDLINE]

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