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1.

Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program.

Moore WC, Bleecker ER, Curran-Everett D, Erzurum SC, Ameredes BT, Bacharier L, Calhoun WJ, Castro M, Chung KF, Clark MP, Dweik RA, Fitzpatrick AM, Gaston B, Hew M, Hussain I, Jarjour NN, Israel E, Levy BD, Murphy JR, Peters SP, Teague WG, Meyers DA, Busse WW, Wenzel SE; National Heart, Lung, Blood Institute's Severe Asthma Research Program.

J Allergy Clin Immunol. 2007 Feb;119(2):405-13.

2.

Characterization of a high TNF-α phenotype in children with moderate-to-severe asthma.

Brown SD, Brown LA, Stephenson S, Dodds JC, Douglas SL, Qu H, Fitzpatrick AM.

J Allergy Clin Immunol. 2015 Jun;135(6):1651-4. doi: 10.1016/j.jaci.2014.08.054. Epub 2015 Feb 26. No abstract available.

PMID:
25725987
3.

Identification of asthma phenotypes in a tertiary care medical center.

Kuhlen JL Jr, Wahlquist AE, Nietert PJ, Bains SN.

Am J Med Sci. 2014 Dec;348(6):480-5. doi: 10.1097/MAJ.0000000000000346.

PMID:
25319436
4.

Neutrophil-like low-density granulocytes are elevated in patients with moderate to severe persistent asthma.

Fu J, Tobin MC, Thomas LL.

Ann Allergy Asthma Immunol. 2014 Dec;113(6):635-640.e2. doi: 10.1016/j.anai.2014.08.024. Epub 2014 Sep 23.

PMID:
25256681
5.

Characteristics and self-rated health of overlap syndrome.

Chung JW, Kong KA, Lee JH, Lee SJ, Ryu YJ, Chang JH.

Int J Chron Obstruct Pulmon Dis. 2014 Jul 21;9:795-804. doi: 10.2147/COPD.S61093. eCollection 2014.

6.

Identifying the heterogeneity of young adult rhinitis through cluster analysis in the Isle of Wight birth cohort.

Kurukulaaratchy RJ, Zhang H, Patil V, Raza A, Karmaus W, Ewart S, Arshad SH.

J Allergy Clin Immunol. 2015 Jan;135(1):143-50. doi: 10.1016/j.jaci.2014.06.017. Epub 2014 Jul 29.

PMID:
25085342
7.

Characterization of airway inflammation in patients with COPD using fractional exhaled nitric oxide levels: a pilot study.

Donohue JF, Herje N, Crater G, Rickard K.

Int J Chron Obstruct Pulmon Dis. 2014 Jul 16;9:745-51. doi: 10.2147/COPD.S44552. eCollection 2014.

8.

Clinical characteristics of asthma combined with COPD feature.

Lee HY, Kang JY, Yoon HK, Lee SY, Kwon SS, Kim YK, Rhee CK.

Yonsei Med J. 2014 Jul;55(4):980-6. doi: 10.3349/ymj.2014.55.4.980.

9.

Lung function decline and variable airway inflammatory pattern: longitudinal analysis of severe asthma.

Newby C, Agbetile J, Hargadon B, Monteiro W, Green R, Pavord I, Brightling C, Siddiqui S.

J Allergy Clin Immunol. 2014 Aug;134(2):287-94. doi: 10.1016/j.jaci.2014.04.005. Epub 2014 Jun 11.

PMID:
24928647
10.

Unsupervised phenotyping of Severe Asthma Research Program participants using expanded lung data.

Wu W, Bleecker E, Moore W, Busse WW, Castro M, Chung KF, Calhoun WJ, Erzurum S, Gaston B, Israel E, Curran-Everett D, Wenzel SE.

J Allergy Clin Immunol. 2014 May;133(5):1280-8. doi: 10.1016/j.jaci.2013.11.042. Epub 2014 Feb 28.

11.

Quality of life, health care utilization, and control in older adults with asthma.

Ross JA, Yang Y, Song PX, Clark NM, Baptist AP.

J Allergy Clin Immunol Pract. 2013 Mar;1(2):157-62. doi: 10.1016/j.jaip.2012.12.003. Epub 2013 Feb 4.

PMID:
24565454
12.

Reduced forced expiratory flow but not increased exhaled nitric oxide or airway responsiveness to methacholine characterises paediatric sickle cell airway disease.

Chaudry RA, Rosenthal M, Bush A, Crowley S.

Thorax. 2014 Jun;69(6):580-5. doi: 10.1136/thoraxjnl-2013-204464. Epub 2014 Feb 12.

PMID:
24523053
13.

Clinical heterogeneity in the severe asthma research program.

Moore WC, Fitzpatrick AM, Li X, Hastie AT, Li H, Meyers DA, Bleecker ER.

Ann Am Thorac Soc. 2013 Dec;10 Suppl:S118-24. doi: 10.1513/AnnalsATS.201309-307AW.

14.

Exhaled matrix metalloproteinase-9 (MMP-9) in different biological phenotypes of asthma.

Barbaro MP, Spanevello A, Palladino GP, Salerno FG, Lacedonia D, Carpagnano GE.

Eur J Intern Med. 2014 Jan;25(1):92-6. doi: 10.1016/j.ejim.2013.08.705. Epub 2013 Sep 23.

PMID:
24070522
15.

Increased IL-17A secreting CD4+ T cells, serum IL-17 levels and exhaled nitric oxide are correlated with childhood asthma severity.

Chien JW, Lin CY, Yang KD, Lin CH, Kao JK, Tsai YG.

Clin Exp Allergy. 2013 Sep;43(9):1018-26. doi: 10.1111/cea.12119.

PMID:
23957337
16.

Severe adult-onset asthma: A distinct phenotype.

Amelink M, de Groot JC, de Nijs SB, Lutter R, Zwinderman AH, Sterk PJ, ten Brinke A, Bel EH.

J Allergy Clin Immunol. 2013 Aug;132(2):336-41. doi: 10.1016/j.jaci.2013.04.052. Epub 2013 Jun 24.

PMID:
23806634
17.

Older adults with asthma: does age of asthma onset make a difference?

Baptist AP, Ross JA, Clark NM.

J Asthma. 2013 Oct;50(8):836-41. doi: 10.3109/02770903.2013.816967. Epub 2013 Jul 25.

PMID:
23782329
18.

Relationship between airway pathophysiology and airway inflammation in older asthmatics.

Porsbjerg CM, Gibson PG, Pretto JJ, Salome CM, Brown NJ, Berend N, King GG.

Respirology. 2013 Oct;18(7):1128-34. doi: 10.1111/resp.12142.

19.

Biomarker surrogates do not accurately predict sputum eosinophil and neutrophil percentages in asthmatic subjects.

Hastie AT, Moore WC, Li H, Rector BM, Ortega VE, Pascual RM, Peters SP, Meyers DA, Bleecker ER; National Heart, Lung, and Blood Institute's Severe Asthma Research Program.

J Allergy Clin Immunol. 2013 Jul;132(1):72-80. doi: 10.1016/j.jaci.2013.03.044. Epub 2013 May 21.

20.

Characteristics of perimenstrual asthma and its relation to asthma severity and control: data from the Severe Asthma Research Program.

Rao CK, Moore CG, Bleecker E, Busse WW, Calhoun W, Castro M, Chung KF, Erzurum SC, Israel E, Curran-Everett D, Wenzel SE.

Chest. 2013 Apr;143(4):984-92. doi: 10.1378/chest.12-0973.

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