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17291493,12591734,14596484,15242764,20210890,12967350,19903469,17292950,17603079,15870947,18359697,17653087,12855663,12973017,11242052,15863139,11280739,12642862,15567514,17562856,22583356,18521960,16932741,15706355,15127126,20856198,16288043,18089776,19393243,19578769,18060503,16869888,17440818,17640673,20395960,16085184,18560353,18438971,17686459,17471230,16540663,15572731,19258513,17724022,17471152,15610860,14576775,17168540,18023397,16603637,16091752,22740515,16044155,15115387,16391810,15843890,12384799,19285749,16957768,16774749,18071312,16687088,21255191,17521628,17962813,22049529,15293984,20213810,17298543,10462484,18807090,23225169,27498621,23252748,17510429,19154411,17488272,21695558,23338568,18177647,18475287,11972398,22609235,16543147,19013033,15023888,16618750,18056177,18822137,18459128,18071906,19578756,14605674,19099231,18829553,11140637,14559854,15721041,24038446,16204022,15317454,18851976,18022363,19584092,15882989,14523016,15183896,18788627,15643501,21077998,26662313,16497409,14742324,16337338,17253597,16394139,15905097,15740652,16927016,29927992,20552279,21286665,16964381,15883009,16651421,22052903,11927604,20633731,23886811,12902979,20980180,16965834,16151649,17069460,16094404,15574755,19799944,22753722,18029193,23156805,20171302,20156429,18973751,15325294,16544101,22117968,16701639,21442307,16322207,18485876,14512414,25220870,20171186,17437405,21166495,26692364,16875166,22491673,26302264,21976617,21833466,20814238,17143747,17188248,21072626,17130844,22552744,18937395,17210228,22397496,16791039,25394481,11406588,11818445,22148838,20731936,16794601,15645134,16796750,21565459,15871184,32447208,15749826,23306356,20063052,28322955,22867709,21676925,22482401,27865841,14560006,11257231,29424923,15207275,16077988,23790005,12749848,17630921,14696123,15709158,27461583,20614162,15588250,20431601,16949641,14532997,16823314,17134788,21543344,16336964,24626292,21479361,23319321,27737687,24395429,16729033,17229588,16596269,12669453,17001176,12894552,10962579,15010875,16982768,16242324,18563329,22497644,24681884,20862799,21354220,12218061,12846571,23166698,17952737,14526223,15118177,20682709,21869827,21597464,17054846,11313486,15078891,26071313,22760199,16231180,21204765,16083549,15788654,17363497,12235797,15505413,28075014,22227574,21382957,19897582,18224693,18590557,20060411,27223062,19513519,14583479,16834387,21947931,26314849,20676365,21340509,19904270,18351648,16230365,18467439,18590777,15685240,20957035,16185655,24563541,24771612,16936720,15781653,18548102,20547836,21242120,18283311,19682522,17035597,17211286,17450518,32182843,26313152,28288130,24521431,17999504,17611394,20443226,15612682,17179183,22446197,15664859,34247143,17038666,18851715,30344003,23337879,12243753,21798574,15886004,16827105,21645409,24841289,20100005,18338251,23915912,23482746,19885569,23714431,15328523,17185628,23570372,17877640,16382148,21426304,25586349,25673090,11484955,23070005,15752357,22776562,25056906,16601104,29513810,18856066,29256070,21785234,17435549,22020922,20119625,26689986,18401527,16781710,23563149,16052231,24463111,29277787,18091317,32020226,16932756,17181177,21897022,22392914,28361942,17916749,15039912,23634213,21237556,15037009,21364680,17611406,17869439,25323693,20067771,24395041,25321484,23865339,25811903,20406824,20572591,15781261,21696964,35613525,20117083,36412426,17336535,22264476,21461584,19010913,36758106,14749118,24824309,17996648,17009030,24176845,16484020,16892093,26554242,32719312,15560849,21642838,22683311,22403616,36108738,26352384,17555401,20667824,21087868,18954041,16962773,16262685,23954782,11483856,30710195,10394958,26567362,20485285,18717598,23979166,22653317,17315041,32270379,29061809,18309650,19737940,36416169,14749124,22200726,16322690,15507451,21709246,15555560,12874265,17245643,32019552,23254244,15842804,22325366,23275033,20843595,17167855,26743718,16868249,31744505,14502234,11445667,36934589,21901386,21118639,31699976,29746926,12624662,17573556,20067634,24552816,21462933,25578648,15683722,25940438,15664855,26232549,22342627,24677341,30123940,25807633,22406265,17234145,23038270,16532278,26177086,25549803,30778852,33713642,37147964,24717152,21418860,20684551,17967870,17273173,19500507,30529563,21128834,17514421,19670614,18956862,23651223,28560455,18487950,21267677,26282728,15848180,30446907,23681224,12522239,11287285,25501826,23254292,21536684,31004702,23999295,18708583,24305822,17168570,15331168,12954335,34638946,14665704,19620011,24270683,37088772,31260151,22083305,31914860,32341447,19698783,35026350,10802696,19590513,15890618,29115633,27087660,32015347,34057526,25695766,20509890,29678905,21387310,22407164,19836248,29250796,29113168,19946707,21387498,28215531,31127027,19138149,31624230,12136201,36711597,17382285,21877153,29631059,17016456,21433357,19191576,30625288,20494979,19105945,16671537,34199423,35740967,25161875,18220537,19911273,21367892,23979156,22415943,23203690,21596015,19333375,24655767,19788411,35661061,19736924,34025452,29946223,31407360,17508928,23586880,25205454,27681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Role of XIAP in inhibiting cisplatin-induced caspase activation in non-small cell lung cancer cells: a small molecule Smac mimic sensitizes for chemotherapy-induced apoptosis by enhancing caspase-3 activation.

Checinska A, Hoogeland BS, Rodriguez JA, Giaccone G, Kruyt FA. Checinska A, et al. Exp Cell Res. 2007 Apr 1;313(6):1215-24. doi: 10.1016/j.yexcr.2006.12.011. Epub 2006 Dec 29. Exp Cell Res. 2007. PMID: 17291493

Predominant suppression of apoptosome by inhibitor of apoptosis protein in non-small cell lung cancer H460 cells: therapeutic effect of a novel polyarginine-conjugated Smac peptide.

Yang L, Mashima T, Sato S, Mochizuki M, Sakamoto H, Yamori T, Oh-Hara T, Tsuruo T. Yang L, et al. Cancer Res. 2003 Feb 15;63(4):831-7. Cancer Res. 2003. PMID: 12591734

X-linked inhibitor regulating TRAIL-induced apoptosis in chemoresistant human primary glioblastoma cells.

Roa WH, Chen H, Fulton D, Gulavita S, Shaw A, Th'ng J, Farr-Jones M, Moore R, Petruk K. Roa WH, et al. Clin Invest Med. 2003 Oct;26(5):231-42. Clin Invest Med. 2003. PMID: 14596484

Endogenously released Smac is insufficient to mediate cell death of human lung carcinoma in response to etoposide.

Bartling B, Lewensohn R, Zhivotovsky B. Bartling B, et al. Exp Cell Res. 2004 Aug 1;298(1):83-95. doi: 10.1016/j.yexcr.2004.04.007. Exp Cell Res. 2004. PMID: 15242764

Prognostic value of survivin, X-linked inhibitor of apoptosis protein and second mitochondria-derived activator of caspases expression in advanced non-small-cell lung cancer patients.

Chen P, Li J, Ge LP, Dai CH, Li XQ. Chen P, et al. Respirology. 2010 Apr;15(3):501-9. doi: 10.1111/j.1440-1843.2010.01710.x. Epub 2010 Feb 24. Respirology. 2010. PMID: 20210890

Opposite regulation of XIAP and Smac/DIABLO in the rat endometrium in response to 17beta-estradiol at estrus.

Leblanc V, Dery MC, Shooner C, Asselin E. Leblanc V, et al. Reprod Biol Endocrinol. 2003 Aug 27;1:59. doi: 10.1186/1477-7827-1-59. Reprod Biol Endocrinol. 2003. PMID: 12967350 Free PMC article.

XIAP-mediated protection of H460 lung cancer cells against cisplatin.

Cheng YJ, Jiang HS, Hsu SL, Lin LC, Wu CL, Ghanta VK, Hsueh CM. Cheng YJ, et al. Eur J Pharmacol. 2010 Feb 10;627(1-3):75-84. doi: 10.1016/j.ejphar.2009.11.003. Epub 2009 Nov 10. Eur J Pharmacol. 2010. PMID: 19903469

A small molecule Smac mimic potentiates TRAIL-mediated cell death of ovarian cancer cells.

Petrucci E, Pasquini L, Petronelli A, Saulle E, Mariani G, Riccioni R, Biffoni M, Ferretti G, Benedetti-Panici P, Cognetti F, Scambia G, Humphreys R, Peschle C, Testa U. Petrucci E, et al. Gynecol Oncol. 2007 May;105(2):481-92. doi: 10.1016/j.ygyno.2007.01.011. Epub 2007 Feb 9. Gynecol Oncol. 2007. PMID: 17292950

Modification of gene products involved in resistance to apoptosis in metastatic colon cancer cells: roles of Fas, Apaf-1, NFkappaB, IAPs, Smac/DIABLO, and AIF.

Huerta S, Heinzerling JH, Anguiano-Hernandez YM, Huerta-Yepez S, Lin J, Chen D, Bonavida B, Livingston EH. Huerta S, et al. J Surg Res. 2007 Sep;142(1):184-94. doi: 10.1016/j.jss.2006.12.551. Epub 2007 Jul 2. J Surg Res. 2007. PMID: 17603079

Defects in apoptotic signal transduction in cisplatin-resistant non-small cell lung cancer cells.

Ikuta K, Takemura K, Kihara M, Naito S, Lee E, Shimizu E, Yamauchi A. Ikuta K, et al. Oncol Rep. 2005 Jun;13(6):1229-34. Oncol Rep. 2005. PMID: 15870947

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