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Telomere dysfunction as a cause of genomic instability in Werner syndrome.

Crabbe L, Jauch A, Naeger CM, Holtgreve-Grez H, Karlseder J.

Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2205-10. Epub 2007 Feb 6.


Telomere instability in a human tumor cell line expressing a dominant-negative WRN protein.

Bai Y, Murnane JP.

Hum Genet. 2003 Sep;113(4):337-47. Epub 2003 Jun 25.


WRN controls formation of extrachromosomal telomeric circles and is required for TRF2DeltaB-mediated telomere shortening.

Li B, Jog SP, Reddy S, Comai L.

Mol Cell Biol. 2008 Mar;28(6):1892-904. doi: 10.1128/MCB.01364-07. Epub 2008 Jan 22.


Telomere ResQue and preservation--roles for the Werner syndrome protein and other RecQ helicases.

Opresko PL.

Mech Ageing Dev. 2008 Jan-Feb;129(1-2):79-90. Epub 2007 Oct 30. Review.


The Werner syndrome helicase is a cofactor for HIV-1 long terminal repeat transactivation and retroviral replication.

Sharma A, Awasthi S, Harrod CK, Matlock EF, Khan S, Xu L, Chan S, Yang H, Thammavaram CK, Rasor RA, Burns DK, Skiest DJ, Van Lint C, Girard AM, McGee M, Monnat RJ Jr, Harrod R.

J Biol Chem. 2007 Apr 20;282(16):12048-57. Epub 2007 Feb 21.


The Saccharomyces cerevisiae WRN homolog Sgs1p participates in telomere maintenance in cells lacking telomerase.

Johnson FB, Marciniak RA, McVey M, Stewart SA, Hahn WC, Guarente L.

EMBO J. 2001 Feb 15;20(4):905-13.


Defective telomere lagging strand synthesis in cells lacking WRN helicase activity.

Crabbe L, Verdun RE, Haggblom CI, Karlseder J.

Science. 2004 Dec 10;306(5703):1951-3.


Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway.

Laud PR, Multani AS, Bailey SM, Wu L, Ma J, Kingsley C, Lebel M, Pathak S, DePinho RA, Chang S.

Genes Dev. 2005 Nov 1;19(21):2560-70.


Role of Werner syndrome gene product helicase in carcinogenesis and in resistance to genotoxins by cancer cells.

Futami K, Ishikawa Y, Goto M, Furuichi Y, Sugimoto M.

Cancer Sci. 2008 May;99(5):843-8. doi: 10.1111/j.1349-7006.2008.00778.x. Epub 2008 Feb 26. Review.


TRF2 recruits the Werner syndrome (WRN) exonuclease for processing of telomeric DNA.

Machwe A, Xiao L, Orren DK.

Oncogene. 2004 Jan 8;23(1):149-56.


[Utilization of Werner syndrome mouse model in studying premature aging and tumor].

Jia ST, Yang SH, Luo Y.

Yi Chuan. 2009 Aug;31(8):785-90. Review. Chinese.


WRN, the protein deficient in Werner syndrome, plays a critical structural role in optimizing DNA repair.

Chen L, Huang S, Lee L, Davalos A, Schiestl RH, Campisi J, Oshima J.

Aging Cell. 2003 Aug;2(4):191-9.


Functional role of the Werner syndrome RecQ helicase in human fibroblasts.

Dhillon KK, Sidorova J, Saintigny Y, Poot M, Gollahon K, Rabinovitch PS, Monnat RJ Jr.

Aging Cell. 2007 Feb;6(1):53-61.


Failure to complement abnormal phenotypes of simian virus 40-transformed Werner syndrome cells by introduction of a normal human chromosome 8.

Kodama S, Kashino G, Suzuki K, Takatsuji T, Okumura Y, Oshimura M, Watanabe M, Barrett JC.

Cancer Res. 1998 Nov 15;58(22):5188-95.


The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2.

Opresko PL, Otterlei M, Graakjaer J, Bruheim P, Dawut L, Kølvraa S, May A, Seidman MM, Bohr VA.

Mol Cell. 2004 Jun 18;14(6):763-74.


p53 modulates RPA-dependent and RPA-independent WRN helicase activity.

Sommers JA, Sharma S, Doherty KM, Karmakar P, Yang Q, Kenny MK, Harris CC, Brosh RM Jr.

Cancer Res. 2005 Feb 15;65(4):1223-33.


Werner protein stimulates topoisomerase I DNA relaxation activity.

Laine JP, Opresko PL, Indig FE, Harrigan JA, von Kobbe C, Bohr VA.

Cancer Res. 2003 Nov 1;63(21):7136-46.


Asymmetry of DNA replication fork progression in Werner's syndrome.

Rodríguez-López AM, Jackson DA, Iborra F, Cox LS.

Aging Cell. 2002 Oct;1(1):30-9.


WRN or telomerase constructs reverse 4-nitroquinoline 1-oxide sensitivity in transformed Werner syndrome fibroblasts.

Hisama FM, Chen YH, Meyn MS, Oshima J, Weissman SM.

Cancer Res. 2000 May 1;60(9):2372-6.


Deficient DNA repair in the human progeroid disorder, Werner syndrome.

Bohr VA.

Mutat Res. 2005 Sep 4;577(1-2):252-9. Review.

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