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Results: 1 to 20 of 109

1.

The p21Waf1 pathway is involved in blocking leukemogenesis by the t(8;21) fusion protein AML1-ETO.

Peterson LF, Yan M, Zhang DE.

Blood. 2007 May 15;109(10):4392-8. Epub 2007 Feb 6.

PMID:
17284535
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

A previously unidentified alternatively spliced isoform of t(8;21) transcript promotes leukemogenesis.

Yan M, Kanbe E, Peterson LF, Boyapati A, Miao Y, Wang Y, Chen IM, Chen Z, Rowley JD, Willman CL, Zhang DE.

Nat Med. 2006 Aug;12(8):945-9. Epub 2006 Jul 30.

PMID:
16892037
[PubMed - indexed for MEDLINE]
3.

AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations.

Yuan Y, Zhou L, Miyamoto T, Iwasaki H, Harakawa N, Hetherington CJ, Burel SA, Lagasse E, Weissman IL, Akashi K, Zhang DE.

Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10398-403.

PMID:
11526243
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Disruption of the NHR4 domain structure in AML1-ETO abrogates SON binding and promotes leukemogenesis.

Ahn EY, Yan M, Malakhova OA, Lo MC, Boyapati A, Ommen HB, Hines R, Hokland P, Zhang DE.

Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):17103-8. doi: 10.1073/pnas.0802696105. Epub 2008 Oct 24.

PMID:
18952841
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

The fusion protein AML1-ETO in acute myeloid leukemia with translocation t(8;21) induces c-jun protein expression via the proximal AP-1 site of the c-jun promoter in an indirect, JNK-dependent manner.

Elsässer A, Franzen M, Kohlmann A, Weisser M, Schnittger S, Schoch C, Reddy VA, Burel S, Zhang DE, Ueffing M, Tenen DG, Hiddemann W, Behre G.

Oncogene. 2003 Aug 28;22(36):5646-57.

PMID:
12944913
[PubMed - indexed for MEDLINE]
6.

Leukemogenic AML1-ETO fusion protein upregulates expression of connexin 43: the role in AML 1-ETO-induced growth arrest in leukemic cells.

Li X, Xu YB, Wang Q, Lu Y, Zheng Y, Wang YC, Lübbert M, Zhao KW, Chen GQ.

J Cell Physiol. 2006 Sep;208(3):594-601.

PMID:
16741927
[PubMed - indexed for MEDLINE]
7.

Transcriptional upregulation of p21/WAF/Cip1 in myeloid leukemic blasts expressing AML1-ETO.

Berg T, Fliegauf M, Burger J, Staege MS, Liu S, Martinez N, Heidenreich O, Burdach S, Haferlach T, Werner MH, Lübbert M.

Haematologica. 2008 Nov;93(11):1728-33. doi: 10.3324/haematol.13044. Epub 2008 Sep 11.

PMID:
18790797
[PubMed - indexed for MEDLINE]
Free Article
8.

The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia.

Vangala RK, Heiss-Neumann MS, Rangatia JS, Singh SM, Schoch C, Tenen DG, Hiddemann W, Behre G.

Blood. 2003 Jan 1;101(1):270-7. Epub 2002 Aug 29.

PMID:
12393465
[PubMed - indexed for MEDLINE]
Free Article
9.

Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia.

Higuchi M, O'Brien D, Kumaravelu P, Lenny N, Yeoh EJ, Downing JR.

Cancer Cell. 2002 Feb;1(1):63-74.

PMID:
12086889
[PubMed - indexed for MEDLINE]
10.

Synergistic up-regulation of the myeloid-specific promoter for the macrophage colony-stimulating factor receptor by AML1 and the t(8;21) fusion protein may contribute to leukemogenesis.

Rhoades KL, Hetherington CJ, Rowley JD, Hiebert SW, Nucifora G, Tenen DG, Zhang DE.

Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11895-900.

PMID:
8876234
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

ETO and AML1 phosphoproteins are expressed in CD34+ hematopoietic progenitors: implications for t(8;21) leukemogenesis and monitoring residual disease.

Erickson PF, Dessev G, Lasher RS, Philips G, Robinson M, Drabkin HA.

Blood. 1996 Sep 1;88(5):1813-23.

PMID:
8781439
[PubMed - indexed for MEDLINE]
Free Article
12.

Targeting of AML1-ETO in t(8;21) leukemia by oridonin generates a tumor suppressor-like protein.

Zhen T, Wu CF, Liu P, Wu HY, Zhou GB, Lu Y, Liu JX, Liang Y, Li KK, Wang YY, Xie YY, He MM, Cao HM, Zhang WN, Chen LM, Petrie K, Chen SJ, Chen Z.

Sci Transl Med. 2012 Mar 28;4(127):127ra38. doi: 10.1126/scitranslmed.3003562.

PMID:
22461642
[PubMed - indexed for MEDLINE]
Free Article
13.

Dominant negative effects of the AML1/ETO fusion oncoprotein.

Fenske TS, Pengue G, Graubert TA.

Cell Cycle. 2005 Jan;4(1):33-6. Epub 2005 Jan 19.

PMID:
15611635
[PubMed - indexed for MEDLINE]
Free Article
14.

The AML1 gene: a transcription factor involved in the pathogenesis of myeloid and lymphoid leukemias.

Lo Coco F, Pisegna S, Diverio D.

Haematologica. 1997 May-Jun;82(3):364-70. Review.

PMID:
9234595
[PubMed - indexed for MEDLINE]
Free Article
15.

The AML1-ETO fusion gene and the FLT3 length mutation collaborate in inducing acute leukemia in mice.

Schessl C, Rawat VP, Cusan M, Deshpande A, Kohl TM, Rosten PM, Spiekermann K, Humphries RK, Schnittger S, Kern W, Hiddemann W, Quintanilla-Martinez L, Bohlander SK, Feuring-Buske M, Buske C.

J Clin Invest. 2005 Aug;115(8):2159-68. Epub 2005 Jul 14.

PMID:
16025155
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches.

Hatlen MA, Wang L, Nimer SD.

Front Med. 2012 Sep;6(3):248-62. doi: 10.1007/s11684-012-0206-6. Epub 2012 Aug 9. Review.

PMID:
22875638
[PubMed - indexed for MEDLINE]
17.

The ETO domain is necessary for the developmental abnormalities associated with AML1-ETO expression in the hematopoietic stem cell compartment in vivo.

de Guzman CG, Johnson A, Klug CA.

Blood Cells Mol Dis. 2003 Mar-Apr;30(2):201-6.

PMID:
12732184
[PubMed - indexed for MEDLINE]
18.

Valproic acid triggers differentiation and apoptosis in AML1/ETO-positive leukemic cells specifically.

Zapotocky M, Mejstrikova E, Smetana K, Stary J, Trka J, Starkova J.

Cancer Lett. 2012 Jun 28;319(2):144-53. doi: 10.1016/j.canlet.2011.12.041. Epub 2012 Jan 17.

PMID:
22261333
[PubMed - indexed for MEDLINE]
19.

Specific protein redirection as a transcriptional therapy approach for t(8;21) leukemia.

Steffen B, Serve H, Berdel WE, Agrawal S, Linggi B, Büchner T, Hiebert SW, Müller-Tidow C.

Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8448-53. Epub 2003 Jun 20.

PMID:
12819347
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Heterochromatic gene repression of the retinoic acid pathway in acute myeloid leukemia.

Fazi F, Zardo G, Gelmetti V, Travaglini L, Ciolfi A, Di Croce L, Rosa A, Bozzoni I, Grignani F, Lo-Coco F, Pelicci PG, Nervi C.

Blood. 2007 May 15;109(10):4432-40. Epub 2007 Jan 23.

PMID:
17244680
[PubMed - indexed for MEDLINE]
Free Article
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