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Specific role of Chk1 phosphorylations in cell survival and checkpoint activation.

Niida H, Katsuno Y, Banerjee B, Hande MP, Nakanishi M.

Mol Cell Biol. 2007 Apr;27(7):2572-81. Epub 2007 Jan 22.


Essential function of Chk1 can be uncoupled from DNA damage checkpoint and replication control.

Wilsker D, Petermann E, Helleday T, Bunz F.

Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20752-7. doi: 10.1073/pnas.0806917106. Epub 2008 Dec 17.


Chk1 C-terminal regulatory phosphorylation mediates checkpoint activation by de-repression of Chk1 catalytic activity.

Walker M, Black EJ, Oehler V, Gillespie DA, Scott MT.

Oncogene. 2009 Jun 18;28(24):2314-23. doi: 10.1038/onc.2009.102. Epub 2009 May 4.


Methods for studying checkpoint kinases - Chk1.

Tapia-Alveal C, O'Connell MJ.

Methods Mol Biol. 2011;782:171-9. doi: 10.1007/978-1-61779-273-1_12.


Rad17 phosphorylation is required for claspin recruitment and Chk1 activation in response to replication stress.

Wang X, Zou L, Lu T, Bao S, Hurov KE, Hittelman WN, Elledge SJ, Li L.

Mol Cell. 2006 Aug 4;23(3):331-41.


A novel mechanism of checkpoint abrogation conferred by Chk1 downregulation.

Xiao Z, Xue J, Sowin TJ, Rosenberg SH, Zhang H.

Oncogene. 2005 Feb 17;24(8):1403-11.


Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint.

Liu Q, Guntuku S, Cui XS, Matsuoka S, Cortez D, Tamai K, Luo G, Carattini-Rivera S, DeMayo F, Bradley A, Donehower LA, Elledge SJ.

Genes Dev. 2000 Jun 15;14(12):1448-59.


Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation.

Gatei M, Sloper K, Sorensen C, Syljuäsen R, Falck J, Hobson K, Savage K, Lukas J, Zhou BB, Bartek J, Khanna KK.

J Biol Chem. 2003 Apr 25;278(17):14806-11. Epub 2003 Feb 14.


DNA damage-induced accumulation of centrosomal Chk1 contributes to its checkpoint function.

Löffler H, Bochtler T, Fritz B, Tews B, Ho AD, Lukas J, Bartek J, Krämer A.

Cell Cycle. 2007 Oct 15;6(20):2541-8. Epub 2007 Jul 30.


p56(chk1) protein kinase is required for the DNA replication checkpoint at 37 degrees C in fission yeast.

Francesconi S, Grenon M, Bouvier D, Baldacci G.

EMBO J. 1997 Mar 17;16(6):1332-41.


Phosphorylation activates Chk1 and is required for checkpoint-mediated cell cycle arrest.

Capasso H, Palermo C, Wan S, Rao H, John UP, O'Connell MJ, Walworth NC.

J Cell Sci. 2002 Dec 1;115(Pt 23):4555-64.


BRCA1-dependent Chk1 phosphorylation triggers partial chromatin disassociation of phosphorylated Chk1 and facilitates S-phase cell cycle arrest.

Yarden RI, Metsuyanim S, Pickholtz I, Shabbeer S, Tellio H, Papa MZ.

Int J Biochem Cell Biol. 2012 Nov;44(11):1761-9. doi: 10.1016/j.biocel.2012.06.026. Epub 2012 Jun 26.


Fission yeast chk1 mutants show distinct responses to different types of DNA damaging treatments.

Francesconi S, Smeets M, Grenon M, Tillit J, Blaisonneau J, Baldacci G.

Genes Cells. 2002 Jul;7(7):663-73.


Regulation of Chk1 includes chromatin association and 14-3-3 binding following phosphorylation on Ser-345.

Jiang K, Pereira E, Maxfield M, Russell B, Goudelock DM, Sanchez Y.

J Biol Chem. 2003 Jul 4;278(27):25207-17. Epub 2003 Apr 3.


Rapid PIKK-dependent release of Chk1 from chromatin promotes the DNA-damage checkpoint response.

Smits VA, Reaper PM, Jackson SP.

Curr Biol. 2006 Jan 24;16(2):150-9. Epub 2005 Dec 15.


Chk1 is haploinsufficient for multiple functions critical to tumor suppression.

Lam MH, Liu Q, Elledge SJ, Rosen JM.

Cancer Cell. 2004 Jul;6(1):45-59.


CHK1 phosphorylates CDC25B during the cell cycle in the absence of DNA damage.

Schmitt E, Boutros R, Froment C, Monsarrat B, Ducommun B, Dozier C.

J Cell Sci. 2006 Oct 15;119(Pt 20):4269-75. Epub 2006 Sep 26.


Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints.

Zhao H, Watkins JL, Piwnica-Worms H.

Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):14795-800. Epub 2002 Oct 24.


Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase.

Krämer A, Mailand N, Lukas C, Syljuåsen RG, Wilkinson CJ, Nigg EA, Bartek J, Lukas J.

Nat Cell Biol. 2004 Sep;6(9):884-91. Epub 2004 Aug 15.

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