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Items: 1 to 20 of 172

1.

Biochemical characterization of human glutamate carboxypeptidase III.

Hlouchová K, Barinka C, Klusák V, Sácha P, Mlcochová P, Majer P, Rulísek L, Konvalinka J.

J Neurochem. 2007 May;101(3):682-96. Epub 2007 Jan 4.

2.

Expression of glutamate carboxypeptidase II in human brain.

Sácha P, Zámecník J, Barinka C, Hlouchová K, Vícha A, Mlcochová P, Hilgert I, Eckschlager T, Konvalinka J.

Neuroscience. 2007 Feb 23;144(4):1361-72. Epub 2006 Dec 5.

PMID:
17150306
3.

Identification of the N-glycosylation sites on glutamate carboxypeptidase II necessary for proteolytic activity.

Barinka C, Sácha P, Sklenár J, Man P, Bezouska K, Slusher BS, Konvalinka J.

Protein Sci. 2004 Jun;13(6):1627-35.

4.

Substrate specificity, inhibition and enzymological analysis of recombinant human glutamate carboxypeptidase II.

Barinka C, Rinnová M, Sácha P, Rojas C, Majer P, Slusher BS, Konvalinka J.

J Neurochem. 2002 Feb;80(3):477-87.

5.

The cloning and characterization of a second brain enzyme with NAAG peptidase activity.

Bzdega T, Crowe SL, Ramadan ER, Sciarretta KH, Olszewski RT, Ojeifo OA, Rafalski VA, Wroblewska B, Neale JH.

J Neurochem. 2004 May;89(3):627-35.

6.

Molecular modeling of the interactions of glutamate carboxypeptidase II with its potent NAAG-based inhibitors.

Rong SB, Zhang J, Neale JH, Wroblewski JT, Wang S, Kozikowski AP.

J Med Chem. 2002 Sep 12;45(19):4140-52.

PMID:
12213057
7.

Mapping of the active site of glutamate carboxypeptidase II by site-directed mutagenesis.

Mlcochová P, Plechanovová A, Barinka C, Mahadevan D, Saldanha JW, Rulísek L, Konvalinka J.

FEBS J. 2007 Sep;274(18):4731-41. Epub 2007 Aug 21.

8.

Amino acids at the N- and C-termini of human glutamate carboxypeptidase II are required for enzymatic activity and proper folding.

Barinka C, Mlcochová P, Sácha P, Hilgert I, Majer P, Slusher BS, Horejsí V, Konvalinka J.

Eur J Biochem. 2004 Jul;271(13):2782-90.

9.

GCPII variants, paralogs and orthologs.

Hlouchová K, Navrátil V, Tykvart J, Sácha P, Konvalinka J.

Curr Med Chem. 2012;19(9):1316-22. Review.

PMID:
22304710
10.
11.

Synthesis of urea-based inhibitors as active site probes of glutamate carboxypeptidase II: efficacy as analgesic agents.

Kozikowski AP, Zhang J, Nan F, Petukhov PA, Grajkowska E, Wroblewski JT, Yamamoto T, Bzdega T, Wroblewska B, Neale JH.

J Med Chem. 2004 Mar 25;47(7):1729-38.

PMID:
15027864
12.

Glutamate carboxypeptidase II does not process amyloid-β peptide.

Sedlák F, Šácha P, Blechová M, Březinová A, Šafařík M, Šebestík J, Konvalinka J.

FASEB J. 2013 Jul;27(7):2626-32. doi: 10.1096/fj.12-225094. Epub 2013 Mar 23.

13.

Structural insight into the evolutionary and pharmacologic homology of glutamate carboxypeptidases II and III.

Hlouchova K, Barinka C, Konvalinka J, Lubkowski J.

FEBS J. 2009 Aug;276(16):4448-62. doi: 10.1111/j.1742-4658.2009.07152.x.

14.
15.

Isolation and expression of novel human glutamate carboxypeptidases with N-acetylated alpha-linked acidic dipeptidase and dipeptidyl peptidase IV activity.

Pangalos MN, Neefs JM, Somers M, Verhasselt P, Bekkers M, van der Helm L, Fraiponts E, Ashton D, Gordon RD.

J Biol Chem. 1999 Mar 26;274(13):8470-83.

16.
17.

Structure of glutamate carboxypeptidase II, a drug target in neuronal damage and prostate cancer.

Mesters JR, Barinka C, Li W, Tsukamoto T, Majer P, Slusher BS, Konvalinka J, Hilgenfeld R.

EMBO J. 2006 Mar 22;25(6):1375-84. Epub 2006 Feb 9.

18.

Human glutamate carboxypeptidase II inhibition: structures of GCPII in complex with two potent inhibitors, quisqualate and 2-PMPA.

Mesters JR, Henning K, Hilgenfeld R.

Acta Crystallogr D Biol Crystallogr. 2007 Apr;63(Pt 4):508-13. Epub 2007 Mar 16.

PMID:
17372356
20.

Deletion of the glutamate carboxypeptidase II gene in mice reveals a second enzyme activity that hydrolyzes N-acetylaspartylglutamate.

Bacich DJ, Ramadan E, O'Keefe DS, Bukhari N, Wegorzewska I, Ojeifo O, Olszewski R, Wrenn CC, Bzdega T, Wroblewska B, Heston WD, Neale JH.

J Neurochem. 2002 Oct;83(1):20-9.

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