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Results: 1 to 20 of 113

1.

The crystal structure of C2a, the catalytic fragment of classical pathway C3 and C5 convertase of human complement.

Krishnan V, Xu Y, Macon K, Volanakis JE, Narayana SV.

J Mol Biol. 2007 Mar 16;367(1):224-33. Epub 2006 Dec 19.

PMID:
17234210
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

The structure of C2b, a fragment of complement component C2 produced during C3 convertase formation.

Krishnan V, Xu Y, Macon K, Volanakis JE, Narayana SV.

Acta Crystallogr D Biol Crystallogr. 2009 Mar;65(Pt 3):266-74. doi: 10.1107/S0907444909000389. Epub 2009 Feb 20.

PMID:
19237749
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Structure of complement component C2A: implications for convertase formation and substrate binding.

Milder FJ, Raaijmakers HC, Vandeputte MD, Schouten A, Huizinga EG, Romijn RA, Hemrika W, Roos A, Daha MR, Gros P.

Structure. 2006 Oct;14(10):1587-97.

PMID:
17027507
[PubMed - indexed for MEDLINE]
Free Article
4.

Formation of high affinity C5 convertase of the classical pathway of complement.

Rawal N, Pangburn MK.

J Biol Chem. 2003 Oct 3;278(40):38476-83. Epub 2003 Jul 23.

PMID:
12878586
[PubMed - indexed for MEDLINE]
Free Article
5.

Structural analysis of engineered Bb fragment of complement factor B: insights into the activation mechanism of the alternative pathway C3-convertase.

Ponnuraj K, Xu Y, Macon K, Moore D, Volanakis JE, Narayana SV.

Mol Cell. 2004 Apr 9;14(1):17-28.

PMID:
15068800
[PubMed - indexed for MEDLINE]
Free Article
6.

A corresponding tyrosine residue in the C2/factor B type A domain is a hot spot in the decay acceleration of the complement C3 convertases.

Kuttner-Kondo LA, Dybvig MP, Mitchell LM, Muqim N, Atkinson JP, Medof ME, Hourcade DE.

J Biol Chem. 2003 Dec 26;278(52):52386-91. Epub 2003 Oct 15.

PMID:
14561755
[PubMed - indexed for MEDLINE]
Free Article
7.

Activation of complement component C5: comparison of C5 convertases of the lectin pathway and the classical pathway of complement.

Rawal N, Rajagopalan R, Salvi VP.

J Biol Chem. 2008 Mar 21;283(12):7853-63. doi: 10.1074/jbc.M707591200. Epub 2008 Jan 18.

PMID:
18204047
[PubMed - indexed for MEDLINE]
Free Article
8.

Complement component C2, inhibiting a latent serine protease in the classical pathway of complement activation.

Halili MA, Ruiz-Gómez G, Le GT, Abbenante G, Fairlie DP.

Biochemistry. 2009 Sep 8;48(35):8466-72. doi: 10.1021/bi900679r.

PMID:
19642650
[PubMed - indexed for MEDLINE]
9.

The mechanism of action of decay-accelerating factor (DAF). DAF inhibits the assembly of C3 convertases by dissociating C2a and Bb.

Fujita T, Inoue T, Ogawa K, Iida K, Tamura N.

J Exp Med. 1987 Nov 1;166(5):1221-8.

PMID:
2445886
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Insights into complement convertase formation based on the structure of the factor B-cobra venom factor complex.

Janssen BJ, Gomes L, Koning RI, Svergun DI, Koster AJ, Fritzinger DC, Vogel CW, Gros P.

EMBO J. 2009 Aug 19;28(16):2469-78. doi: 10.1038/emboj.2009.184. Epub 2009 Jul 2.

PMID:
19574954
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Mechanism of action of the C4 nephritic factor. Deregulation of the classical pathway of C3 convertase.

Gigli I, Sorvillo J, Mecarelli-Halbwachs L, Leibowitch J.

J Exp Med. 1981 Jul 1;154(1):1-12.

PMID:
7019379
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Structural biology of the alternative pathway convertase.

Xu Y, Narayana SV, Volanakis JE.

Immunol Rev. 2001 Apr;180:123-35. Review.

PMID:
11414354
[PubMed - indexed for MEDLINE]
13.

The human complement system: assembly of the classical pathway C3 convertase.

Kerr MA.

Biochem J. 1980 Jul 1;189(1):173-81.

PMID:
6906228
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

A model system for the study of the assembly and regulation of human complement C3 convertase (classical pathway).

Thielens NM, Colomb MG.

Eur J Immunol. 1986 Jun;16(6):617-22.

PMID:
3487454
[PubMed - indexed for MEDLINE]
15.

Structure and function of complement C5 convertase enzymes.

Pangburn MK, Rawal N.

Biochem Soc Trans. 2002 Nov;30(Pt 6):1006-10. Review.

PMID:
12440962
[PubMed - indexed for MEDLINE]
16.

Protection of the classical and alternative complement pathway C3 convertases, stabilized by nephritic factors, from decay by the human C3b receptor.

Fischer E, Kazatchkine MD, Mecarelli-Halbwachs L.

Eur J Immunol. 1984 Dec;14(12):1111-4.

PMID:
6240408
[PubMed - indexed for MEDLINE]
17.

3D structure of the C3bB complex provides insights into the activation and regulation of the complement alternative pathway convertase.

Torreira E, Tortajada A, Montes T, Rodríguez de Córdoba S, Llorca O.

Proc Natl Acad Sci U S A. 2009 Jan 20;106(3):882-7. doi: 10.1073/pnas.0810860106. Epub 2009 Jan 9.

PMID:
19136636
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Mouse complement component C4 is devoid of classical pathway C5 convertase subunit activity.

Ebanks RO, Isenman DE.

Mol Immunol. 1996 Feb;33(3):297-309.

PMID:
8649451
[PubMed - indexed for MEDLINE]
19.

The role of properdin in the assembly of the alternative pathway C3 convertases of complement.

Hourcade DE.

J Biol Chem. 2006 Jan 27;281(4):2128-32. Epub 2005 Nov 21.

PMID:
16301317
[PubMed - indexed for MEDLINE]
Free Article
20.

Cleavage of C2 by C1s into the antigenically distinct fragments C2a and C2b: demonstration of binding of C2b to C4b.

Nagasawa S, Stroud RM.

Proc Natl Acad Sci U S A. 1977 Jul;74(7):2998-3001.

PMID:
70787
[PubMed - indexed for MEDLINE]
Free PMC Article

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