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Items: 1 to 20 of 413


Structural basis of integrin activation by talin.

Wegener KL, Partridge AW, Han J, Pickford AR, Liddington RC, Ginsberg MH, Campbell ID.

Cell. 2007 Jan 12;128(1):171-82.


The phosphotyrosine binding-like domain of talin activates integrins.

Calderwood DA, Yan B, de Pereda JM, Alvarez BG, Fujioka Y, Liddington RC, Ginsberg MH.

J Biol Chem. 2002 Jun 14;277(24):21749-58. Epub 2002 Apr 3.


Cooperative role of the membrane-proximal and -distal residues of the integrin beta3 cytoplasmic domain in regulation of talin-mediated alpha IIb beta3 activation.

Hato T, Yamanouchi J, Tamura T, Yakushijin Y, Sakai I, Yasukawa M.

J Biol Chem. 2008 Feb 29;283(9):5662-8. doi: 10.1074/jbc.M707246200. Epub 2008 Jan 2.


Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling.

Calderwood DA, Fujioka Y, de Pereda JM, García-Alvarez B, Nakamoto T, Margolis B, McGlade CJ, Liddington RC, Ginsberg MH.

Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2272-7. Epub 2003 Feb 26.


Structural determinants of integrin recognition by talin.

García-Alvarez B, de Pereda JM, Calderwood DA, Ulmer TS, Critchley D, Campbell ID, Ginsberg MH, Liddington RC.

Mol Cell. 2003 Jan;11(1):49-58.


Kindlin-1 and -2 directly bind the C-terminal region of beta integrin cytoplasmic tails and exert integrin-specific activation effects.

Harburger DS, Bouaouina M, Calderwood DA.

J Biol Chem. 2009 Apr 24;284(17):11485-97. doi: 10.1074/jbc.M809233200. Epub 2009 Feb 23.


A fluorescence cell biology approach to map the second integrin-binding site of talin to a 130-amino acid sequence within the rod domain.

Tremuth L, Kreis S, Melchior C, Hoebeke J, Rondé P, Plançon S, Takeda K, Kieffer N.

J Biol Chem. 2004 May 21;279(21):22258-66. Epub 2004 Mar 18.


Competition for talin results in trans-dominant inhibition of integrin activation.

Calderwood DA, Tai V, Di Paolo G, De Camilli P, Ginsberg MH.

J Biol Chem. 2004 Jul 9;279(28):28889-95. Epub 2004 May 13.


Reconstructing and deconstructing agonist-induced activation of integrin alphaIIbbeta3.

Han J, Lim CJ, Watanabe N, Soriani A, Ratnikov B, Calderwood DA, Puzon-McLaughlin W, Lafuente EM, Boussiotis VA, Shattil SJ, Ginsberg MH.

Curr Biol. 2006 Sep 19;16(18):1796-806.


Effects of mutations in the cytoplasmic domain of integrin beta(1) to talin binding and cell spreading.

Kääpä A, Peter K, Ylänne J.

Exp Cell Res. 1999 Aug 1;250(2):524-34.


The N-terminal domains of talin cooperate with the phosphotyrosine binding-like domain to activate beta1 and beta3 integrins.

Bouaouina M, Lad Y, Calderwood DA.

J Biol Chem. 2008 Mar 7;283(10):6118-25. doi: 10.1074/jbc.M709527200. Epub 2007 Dec 28.


The molecular basis of filamin binding to integrins and competition with talin.

Kiema T, Lad Y, Jiang P, Oxley CL, Baldassarre M, Wegener KL, Campbell ID, Ylänne J, Calderwood DA.

Mol Cell. 2006 Feb 3;21(3):337-47.


Talin binding to integrin beta tails: a final common step in integrin activation.

Tadokoro S, Shattil SJ, Eto K, Tai V, Liddington RC, de Pereda JM, Ginsberg MH, Calderwood DA.

Science. 2003 Oct 3;302(5642):103-6.


The NPIY motif in the integrin beta1 tail dictates the requirement for talin-1 in outside-in signaling.

Nieves B, Jones CW, Ward R, Ohta Y, Reverte CG, LaFlamme SE.

J Cell Sci. 2010 Apr 15;123(Pt 8):1216-26. doi: 10.1242/jcs.056549. Epub 2010 Mar 23.


The integrin binding site 2 (IBS2) in the talin rod domain is essential for linking integrin beta subunits to the cytoskeleton.

Moes M, Rodius S, Coleman SJ, Monkley SJ, Goormaghtigh E, Tremuth L, Kox C, van der Holst PP, Critchley DR, Kieffer N.

J Biol Chem. 2007 Jun 8;282(23):17280-8. Epub 2007 Apr 11.


The Talin head domain binds to integrin beta subunit cytoplasmic tails and regulates integrin activation.

Calderwood DA, Zent R, Grant R, Rees DJ, Hynes RO, Ginsberg MH.

J Biol Chem. 1999 Oct 1;274(40):28071-4.


Beta integrin tyrosine phosphorylation is a conserved mechanism for regulating talin-induced integrin activation.

Anthis NJ, Haling JR, Oxley CL, Memo M, Wegener KL, Lim CJ, Ginsberg MH, Campbell ID.

J Biol Chem. 2009 Dec 25;284(52):36700-10. doi: 10.1074/jbc.M109.061275. Epub 2009 Oct 20.


Domain-specific interactions of talin with the membrane-proximal region of the integrin beta3 subunit.

Ulmer TS, Calderwood DA, Ginsberg MH, Campbell ID.

Biochemistry. 2003 Jul 15;42(27):8307-12.

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