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Items: 1 to 20 of 101

1.

Characterization of monoclonal antibodies to human soluble MD-2 protein.

Viriyakosol S, McCray PB, Ashbaugh ME, Chu J, Jia HP, Weiss J, Kirkland TN.

Hybridoma (Larchmt). 2006 Dec;25(6):349-57.

PMID:
17203997
2.

MD-2-dependent human Toll-like receptor 4 monoclonal antibodies detect extracellular association of Toll-like receptor 4 with extrinsic soluble MD-2 on the cell surface.

Tsukamoto H, Ihara H, Ito R, Ukai I, Suzuki N, Kimoto M, Tomioka Y, Ikeda Y.

Biochem Biophys Res Commun. 2013 Oct 11;440(1):31-6. doi: 10.1016/j.bbrc.2013.09.004. Epub 2013 Sep 8.

PMID:
24021278
3.

Recombinant soluble forms of extracellular TLR4 domain and MD-2 inhibit lipopolysaccharide binding on cell surface and dampen lipopolysaccharide-induced pulmonary inflammation in mice.

Mitsuzawa H, Nishitani C, Hyakushima N, Shimizu T, Sano H, Matsushima N, Fukase K, Kuroki Y.

J Immunol. 2006 Dec 1;177(11):8133-9.

4.

Isolation of monomeric and dimeric secreted MD-2. Endotoxin.sCD14 and Toll-like receptor 4 ectodomain selectively react with the monomeric form of secreted MD-2.

Teghanemt A, Widstrom RL, Gioannini TL, Weiss JP.

J Biol Chem. 2008 Aug 8;283(32):21881-9. doi: 10.1074/jbc.M800672200. Epub 2008 Jun 2.

5.

Multiple potential regulatory sites of TLR4 activation induced by LPS as revealed by novel inhibitory human TLR4 mAbs.

Tsukamoto H, Fukudome K, Takao S, Tsuneyoshi N, Ihara H, Ikeda Y, Kimoto M.

Int Immunol. 2012 Aug;24(8):495-506. doi: 10.1093/intimm/dxs053. Epub 2012 Apr 12.

6.

Interaction of soluble form of recombinant extracellular TLR4 domain with MD-2 enables lipopolysaccharide binding and attenuates TLR4-mediated signaling.

Hyakushima N, Mitsuzawa H, Nishitani C, Sano H, Kuronuma K, Konishi M, Himi T, Miyake K, Kuroki Y.

J Immunol. 2004 Dec 1;173(11):6949-54.

7.

Toll-like receptor 4 region Glu24-Lys47 is a site for MD-2 binding: importance of CYS29 and CYS40.

Nishitani C, Mitsuzawa H, Sano H, Shimizu T, Matsushima N, Kuroki Y.

J Biol Chem. 2006 Dec 15;281(50):38322-9. Epub 2006 Oct 20.

8.

Preparation and characterization of agonistic monoclonal antibodies against Toll-like receptor 4-MD-2 complex.

Bahrun U, Kimoto M, Tsukamoto H, Tsuneyoshi N, Kohara J, Fukudome K.

Hybridoma (Larchmt). 2007 Dec;26(6):393-9.

PMID:
18158784
9.

Mutational analysis of membrane and soluble forms of human MD-2.

Viriyakosol S, Tobias PS, Kirkland TN.

J Biol Chem. 2006 Apr 28;281(17):11955-64. Epub 2006 Feb 8.

10.

Pharmacological inhibition of endotoxin responses is achieved by targeting the TLR4 coreceptor, MD-2.

Visintin A, Halmen KA, Latz E, Monks BG, Golenbock DT.

J Immunol. 2005 Nov 15;175(10):6465-72.

11.

Bordetella pertussis Lipid A Recognition by Toll-like Receptor 4 and MD-2 Is Dependent on Distinct Charged and Uncharged Interfaces.

Maeshima N, Evans-Atkinson T, Hajjar AM, Fernandez RC.

J Biol Chem. 2015 May 22;290(21):13440-53. doi: 10.1074/jbc.M115.653881. Epub 2015 Apr 2.

PMID:
25837248
12.

Soluble MD-2 activity in plasma from patients with severe sepsis and septic shock.

Pugin J, Stern-Voeffray S, Daubeuf B, Matthay MA, Elson G, Dunn-Siegrist I.

Blood. 2004 Dec 15;104(13):4071-9. Epub 2004 Aug 24.

13.

Surfactant protein A directly interacts with TLR4 and MD-2 and regulates inflammatory cellular response. Importance of supratrimeric oligomerization.

Yamada C, Sano H, Shimizu T, Mitsuzawa H, Nishitani C, Himi T, Kuroki Y.

J Biol Chem. 2006 Aug 4;281(31):21771-80. Epub 2006 Jun 5.

14.

Mannose binding lectin and lung collectins interact with Toll-like receptor 4 and MD-2 by different mechanisms.

Shimizu T, Nishitani C, Mitsuzawa H, Ariki S, Takahashi M, Ohtani K, Wakamiya N, Kuroki Y.

Biochim Biophys Acta. 2009 Dec;1790(12):1705-10. doi: 10.1016/j.bbagen.2009.10.006. Epub 2009 Oct 17.

PMID:
19840833
15.

Glycyrrhizin and isoliquiritigenin suppress the LPS sensor toll-like receptor 4/MD-2 complex signaling in a different manner.

Honda H, Nagai Y, Matsunaga T, Saitoh S, Akashi-Takamura S, Hayashi H, Fujii I, Miyake K, Muraguchi A, Takatsu K.

J Leukoc Biol. 2012 Jun;91(6):967-76. doi: 10.1189/jlb.0112038. Epub 2012 Mar 15.

16.

A designed TLR4/MD-2 complex to capture LPS.

Brandl K, Glück T, Hartmann P, Salzberger B, Falk W.

J Endotoxin Res. 2005;11(4):197-206. Erratum in: J Endotoxin Res. 2012 Aug;18(4):672.

PMID:
16176655
17.

Paclitaxel binding to human and murine MD-2.

Zimmer SM, Liu J, Clayton JL, Stephens DS, Snyder JP.

J Biol Chem. 2008 Oct 10;283(41):27916-26. doi: 10.1074/jbc.M802826200. Epub 2008 Jul 23.

18.

The RP105/MD-1 complex is indispensable for TLR4/MD-2-dependent proliferation and IgM-secreting plasma cell differentiation of marginal zone B cells.

Nagai Y, Yanagibashi T, Watanabe Y, Ikutani M, Kariyone A, Ohta S, Hirai Y, Kimoto M, Miyake K, Takatsu K.

Int Immunol. 2012 Jun;24(6):389-400. doi: 10.1093/intimm/dxs040. Epub 2012 Feb 21.

19.

Activation of Toll-like receptors by Burkholderia pseudomallei.

West TE, Ernst RK, Jansson-Hutson MJ, Skerrett SJ.

BMC Immunol. 2008 Aug 8;9:46. doi: 10.1186/1471-2172-9-46.

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