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Results: 1 to 20 of 102

1.

HERG is protected from pharmacological block by alpha-1,2-glucosyltransferase function.

Nakajima T, Hayashi K, Viswanathan PC, Kim MY, Anghelescu M, Barksdale KA, Shuai W, Balser JR, Kupershmidt S.

J Biol Chem. 2007 Feb 23;282(8):5506-13. Epub 2006 Dec 21.

PMID:
17189275
[PubMed - indexed for MEDLINE]
Free Article
2.

A KCR1 variant implicated in susceptibility to the long QT syndrome.

Hayashi K, Fujino N, Ino H, Uchiyama K, Sakata K, Konno T, Masuta E, Funada A, Sakamoto Y, Tsubokawa T, Hodatsu A, Yasuda T, Kanaya H, Kim MY, Kupershmidt S, Higashida H, Yamagishi M.

J Mol Cell Cardiol. 2011 Jan;50(1):50-7. doi: 10.1016/j.yjmcc.2010.10.007. Epub 2010 Oct 13.

PMID:
20950623
[PubMed - indexed for MEDLINE]
3.

[HERG K+ channel, the target of anti-arrhythmias drugs].

Guan FY, Yang SJ.

Yao Xue Xue Bao. 2007 Jul;42(7):687-91. Review. Chinese.

PMID:
17882949
[PubMed - indexed for MEDLINE]
4.

The cardiac hERG/IKr potassium channel as pharmacological target: structure, function, regulation, and clinical applications.

Thomas D, Karle CA, Kiehn J.

Curr Pharm Des. 2006;12(18):2271-83. Review.

PMID:
16787254
[PubMed - indexed for MEDLINE]
5.

The IKr drug response is modulated by KCR1 in transfected cardiac and noncardiac cell lines.

Kupershmidt S, Yang IC, Hayashi K, Wei J, Chanthaphaychith S, Petersen CI, Johns DC, George AL Jr, Roden DM, Balser JR.

FASEB J. 2003 Dec;17(15):2263-5. Epub 2003 Oct 2.

PMID:
14525949
[PubMed - indexed for MEDLINE]
Free Article
6.

hERG channel trafficking: novel targets in drug-induced long QT syndrome.

Dennis A, Wang L, Wan X, Ficker E.

Biochem Soc Trans. 2007 Nov;35(Pt 5):1060-3. Review.

PMID:
17956279
[PubMed - indexed for MEDLINE]
7.

Altering extracellular potassium concentration does not modulate drug block of human ether-a-go-go-related gene (hERG) channels.

Limberis JT, Su Z, Cox BF, Gintant GA, Martin RL.

Clin Exp Pharmacol Physiol. 2006 Nov;33(11):1059-65.

PMID:
17042915
[PubMed - indexed for MEDLINE]
8.

2-[2-(3,4-dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic acid (PD-307243) causes instantaneous current through human ether-a-go-go-related gene potassium channels.

Gordon E, Lozinskaya IM, Lin Z, Semus SF, Blaney FE, Willette RN, Xu X.

Mol Pharmacol. 2008 Mar;73(3):639-51. Epub 2007 Nov 27.

PMID:
18042732
[PubMed - indexed for MEDLINE]
Free Article
9.

Human ether-a-go-go related gene (hERG) K+ channels: function and dysfunction.

Perrin MJ, Subbiah RN, Vandenberg JI, Hill AP.

Prog Biophys Mol Biol. 2008 Oct-Nov;98(2-3):137-48. doi: 10.1016/j.pbiomolbio.2008.10.006. Epub 2008 Nov 5. Review.

PMID:
19027781
[PubMed - indexed for MEDLINE]
10.

C-terminal HERG (LQT2) mutations disrupt IKr channel regulation through 14-3-3epsilon.

Choe CU, Schulze-Bahr E, Neu A, Xu J, Zhu ZI, Sauter K, Bähring R, Priori S, Guicheney P, Mönnig G, Neapolitano C, Heidemann J, Clancy CE, Pongs O, Isbrandt D.

Hum Mol Genet. 2006 Oct 1;15(19):2888-902. Epub 2006 Aug 21.

PMID:
16923798
[PubMed - indexed for MEDLINE]
Free Article
11.

In vivo identification of genes that modify ether-a-go-go-related gene activity in Caenorhabditis elegans may also affect human cardiac arrhythmia.

Petersen CI, McFarland TR, Stepanovic SZ, Yang P, Reiner DJ, Hayashi K, George AL, Roden DM, Thomas JH, Balser JR.

Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11773-8. Epub 2004 Jul 27.

PMID:
15280551
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Drug binding to the inactivated state is necessary but not sufficient for high-affinity binding to human ether-à-go-go-related gene channels.

Perrin MJ, Kuchel PW, Campbell TJ, Vandenberg JI.

Mol Pharmacol. 2008 Nov;74(5):1443-52. doi: 10.1124/mol.108.049056. Epub 2008 Aug 13.

PMID:
18701618
[PubMed - indexed for MEDLINE]
Free Article
13.

Trafficking-competent KCNQ1 variably influences the function of HERG long QT alleles.

Hayashi K, Shuai W, Sakamoto Y, Higashida H, Yamagishi M, Kupershmidt S.

Heart Rhythm. 2010 Jul;7(7):973-80. doi: 10.1016/j.hrthm.2010.03.038. Epub 2010 Mar 27.

PMID:
20348026
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Analogs of MK-499 are differentially affected by a mutation in the S6 domain of the hERG K+ channel.

Karczewski J, Wang J, Kane SA, Kiss L, Koblan KS, Culberson JC, Spencer RH.

Biochem Pharmacol. 2009 May 15;77(10):1602-11. doi: 10.1016/j.bcp.2009.02.011. Epub 2009 Feb 27.

PMID:
19426697
[PubMed - indexed for MEDLINE]
15.

Long QT syndrome-associated I593R mutation in HERG potassium channel activates ER stress pathways.

Keller SH, Platoshyn O, Yuan JX.

Cell Biochem Biophys. 2005;43(3):365-77.

PMID:
16244363
[PubMed - indexed for MEDLINE]
16.

Effects of phosphodiesterase (PDE) inhibitors on human ether-a-go-go related gene (hERG) channel activity.

Yunomae K, Ichisaki S, Matsuo J, Nagayama S, Fukuzaki K, Nagata R, Kito G.

J Appl Toxicol. 2007 Jan-Feb;27(1):78-85.

PMID:
17146843
[PubMed - indexed for MEDLINE]
17.

Identification of IKr and its trafficking disruption induced by probucol in cultured neonatal rat cardiomyocytes.

Guo J, Massaeli H, Li W, Xu J, Luo T, Shaw J, Kirshenbaum LA, Zhang S.

J Pharmacol Exp Ther. 2007 Jun;321(3):911-20. Epub 2007 Mar 21.

PMID:
17377062
[PubMed - indexed for MEDLINE]
Free Article
18.

Torsadogenic cardiotoxicity of antipsychotic drugs: a structural feature, potentially involved in the interaction with cardiac HERG potassium channels.

Testai L, Bianucci AM, Massarelli I, Breschi MC, Martinotti E, Calderone V.

Curr Med Chem. 2004 Oct;11(20):2691-706. Review.

PMID:
15544470
[PubMed - indexed for MEDLINE]
19.

In silico prediction of the chemical block of human ether-a-go-go-related gene (hERG) K+ current.

Inanobe A, Kamiya N, Murakami S, Fukunishi Y, Nakamura H, Kurachi Y.

J Physiol Sci. 2008 Dec;58(7):459-70. doi: 10.2170/physiolsci.RV-0114-08-07-R1. Epub 2008 Nov 27.

PMID:
19032804
[PubMed - indexed for MEDLINE]
20.

Improved functional expression of recombinant human ether-a-go-go (hERG) K+ channels by cultivation at reduced temperature.

Chen MX, Sandow SL, Doceul V, Chen YH, Harper H, Hamilton B, Meadows HJ, Trezise DJ, Clare JJ.

BMC Biotechnol. 2007 Dec 20;7:93.

PMID:
18096051
[PubMed - indexed for MEDLINE]
Free PMC Article

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