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Results: 1 to 20 of 68

1.

Application of visualization tools to the analysis of histopathological data enhances biological insight and interpretation.

Lobenhofer EK, Boorman GA, Phillips KL, Heinloth AN, Malarkey DE, Blackshear PE, Houle C, Hurban P.

Toxicol Pathol. 2006;34(7):921-8.

PMID:
17178692
[PubMed - indexed for MEDLINE]
Free Article
2.

Utilization of a one-dimensional score for surveying chemical-induced changes in expression levels of multiple biomarker gene sets using a large-scale toxicogenomics database.

Kiyosawa N, Shiwaku K, Hirode M, Omura K, Uehara T, Shimizu T, Mizukawa Y, Miyagishima T, Ono A, Nagao T, Urushidani T.

J Toxicol Sci. 2006 Dec;31(5):433-48.

PMID:
17202759
[PubMed - indexed for MEDLINE]
Free Article
3.

Sources of variation in baseline gene expression levels from toxicogenomics study control animals across multiple laboratories.

Boedigheimer MJ, Wolfinger RD, Bass MB, Bushel PR, Chou JW, Cooper M, Corton JC, Fostel J, Hester S, Lee JS, Liu F, Liu J, Qian HR, Quackenbush J, Pettit S, Thompson KL.

BMC Genomics. 2008 Jun 12;9:285. doi: 10.1186/1471-2164-9-285.

PMID:
18549499
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Simultaneous clustering of gene expression data with clinical chemistry and pathological evaluations reveals phenotypic prototypes.

Bushel PR, Wolfinger RD, Gibson G.

BMC Syst Biol. 2007 Feb 23;1:15.

PMID:
17408499
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Gene expression response in target organ and whole blood varies as a function of target organ injury phenotype.

Lobenhofer EK, Auman JT, Blackshear PE, Boorman GA, Bushel PR, Cunningham ML, Fostel JM, Gerrish K, Heinloth AN, Irwin RD, Malarkey DE, Merrick BA, Sieber SO, Tucker CJ, Ward SM, Wilson RE, Hurban P, Tennant RW, Paules RS.

Genome Biol. 2008;9(6):R100. doi: 10.1186/gb-2008-9-6-r100. Epub 2008 Jun 20.

PMID:
18570634
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Gene expression profiling of methapyrilene-induced hepatotoxicity in rat.

Uehara T, Kiyosawa N, Hirode M, Omura K, Shimizu T, Ono A, Mizukawa Y, Miyagishima T, Nagao T, Urushidani T.

J Toxicol Sci. 2008 Feb;33(1):37-50.

PMID:
18303183
[PubMed - indexed for MEDLINE]
Free Article
7.

Optimization of an animal test protocol for toxicogenomics studies (ii); a cross-laboratory gene expression analysis.

Sumida K, Saito K, Oeda K, Otsuka M, Tsujimura K, Miyaura H, Sekijima M, Nakayama K, Kawano Y, Kawakami Y, Asamoto M, Shirai T.

J Toxicol Sci. 2007 Feb;32(1):33-45.

PMID:
17327692
[PubMed - indexed for MEDLINE]
Free Article
8.

Toxicogenomics.

Gomase VS, Tagore S.

Curr Drug Metab. 2008 Mar;9(3):250-4. Review.

PMID:
18336230
[PubMed - indexed for MEDLINE]
9.

Genes related to apoptosis predict necrosis of the liver as a phenotype observed in rats exposed to a compendium of hepatotoxicants.

Huang L, Heinloth AN, Zeng ZB, Paules RS, Bushel PR.

BMC Genomics. 2008 Jun 16;9:288. doi: 10.1186/1471-2164-9-288.

PMID:
18558008
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Species-specific differences in coumarin-induced hepatotoxicity as an example toxicogenomics-based approach to assessing risk of toxicity to humans.

Uehara T, Kiyosawa N, Shimizu T, Omura K, Hirode M, Imazawa T, Mizukawa Y, Ono A, Miyagishima T, Nagao T, Urushidani T.

Hum Exp Toxicol. 2008 Jan;27(1):23-35. doi: 10.1177/0960327107087910.

PMID:
18480146
[PubMed - indexed for MEDLINE]
11.

Toxicogenomics: transcription profiling for toxicology assessment.

Zhou T, Chou J, Watkins PB, Kaufmann WK.

EXS. 2009;99:325-66. Review.

PMID:
19157067
[PubMed - indexed for MEDLINE]
12.

System-wide analysis of hepatotoxicological responses: tissomics is key.

Kriete A, Boyce K, Love B.

Cytometry A. 2006 Jul;69(7):612-9.

PMID:
16680687
[PubMed - indexed for MEDLINE]
Free Article
13.

The intelligent data management system for toxicogenomics.

Lee WS, Lee GJ, Lee GJ, Yeo CD, Kang JS, Kim YH, Kim SJ, Kim JS, Hwang SY, Park JS, Hwang JW, Kang KS, Lee YS, Jeon KS, Um CH, Hong SI, Kim YS.

J Vet Med Sci. 2004 Nov;66(11):1335-8.

PMID:
15585945
[PubMed - indexed for MEDLINE]
Free Article
14.

Application of Multi-SOM clustering approach to macrophage gene expression analysis.

Ghouila A, Yahia SB, Malouche D, Jmel H, Laouini D, Guerfali FZ, Abdelhak S.

Infect Genet Evol. 2009 May;9(3):328-36. doi: 10.1016/j.meegid.2008.09.009. Epub 2008 Oct 17.

PMID:
18992849
[PubMed - indexed for MEDLINE]
15.

Chemical effects in biological systems--data dictionary (CEBS-DD): a compendium of terms for the capture and integration of biological study design description, conventional phenotypes, and 'omics data.

Fostel J, Choi D, Zwickl C, Morrison N, Rashid A, Hasan A, Bao W, Richard A, Tong W, Bushel PR, Brown R, Bruno M, Cunningham ML, Dix D, Eastin W, Frade C, Garcia A, Heinloth A, Irwin R, Madenspacher J, Merrick BA, Papoian T, Paules R, Rocca-Serra P, Sansone AS, Stevens J, Tomer K, Yang C, Waters M.

Toxicol Sci. 2005 Dec;88(2):585-601. Epub 2005 Sep 8.

PMID:
16150882
[PubMed - indexed for MEDLINE]
Free Article
16.

Identification of genomic biomarkers for concurrent diagnosis of drug-induced renal tubular injury using a large-scale toxicogenomics database.

Kondo C, Minowa Y, Uehara T, Okuno Y, Nakatsu N, Ono A, Maruyama T, Kato I, Yamate J, Yamada H, Ohno Y, Urushidani T.

Toxicology. 2009 Nov 9;265(1-2):15-26. doi: 10.1016/j.tox.2009.09.003. Epub 2009 Sep 15.

PMID:
19761811
[PubMed - indexed for MEDLINE]
17.

Toxicogenomics in biomarker discovery.

Decristofaro MF, Daniels KK.

Methods Mol Biol. 2008;460:185-94. doi: 10.1007/978-1-60327-048-9_9.

PMID:
18449488
[PubMed - indexed for MEDLINE]
18.

Toxicogenomic analysis of N-nitrosomorpholine induced changes in rat liver: comparison of genomic and proteomic responses and anchoring to histopathological parameters.

Oberemm A, Ahr HJ, Bannasch P, Ellinger-Ziegelbauer H, Glückmann M, Hellmann J, Ittrich C, Kopp-Schneider A, Kramer PJ, Krause E, Kröger M, Kiss E, Richter-Reichhelm HB, Scholz G, Seemann K, Weimer M, Gundert-Remy U.

Toxicol Appl Pharmacol. 2009 Dec 1;241(2):230-45. doi: 10.1016/j.taap.2009.08.020. Epub 2009 Aug 28.

PMID:
19716841
[PubMed - indexed for MEDLINE]
19.

Identification of differentially expressed gene categories in microarray studies using nonparametric multivariate analysis.

Nettleton D, Recknor J, Reecy JM.

Bioinformatics. 2008 Jan 15;24(2):192-201. Epub 2007 Nov 27.

PMID:
18042553
[PubMed - indexed for MEDLINE]
Free Article
20.

A toxicogenomics-based parallelogram approach to evaluate the relevance of coumarin-induced responses in primary human hepatocytes in vitro for humans in vivo.

Kienhuis AS, van de Poll MC, Dejong CH, Gottschalk R, van Herwijnen M, Boorsma A, Kleinjans JC, Stierum RH, van Delft JH.

Toxicol In Vitro. 2009 Sep;23(6):1163-9. doi: 10.1016/j.tiv.2009.06.005. Epub 2009 Jun 13.

PMID:
19527782
[PubMed - indexed for MEDLINE]

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