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Items: 1 to 20 of 310


Alterations in regulation of energy homeostasis in cyclic nucleotide phosphodiesterase 3B-null mice.

Choi YH, Park S, Hockman S, Zmuda-Trzebiatowska E, Svennelid F, Haluzik M, Gavrilova O, Ahmad F, Pepin L, Napolitano M, Taira M, Sundler F, Stenson Holst L, Degerman E, Manganiello VC.

J Clin Invest. 2006 Dec;116(12):3240-51.


Beta-cell-targeted overexpression of phosphodiesterase 3B in mice causes impaired insulin secretion, glucose intolerance, and deranged islet morphology.

Härndahl L, Wierup N, Enerbäck S, Mulder H, Manganiello VC, Sundler F, Degerman E, Ahrén B, Holst LS.

J Biol Chem. 2004 Apr 9;279(15):15214-22. Epub 2004 Jan 20.


Early and rapid development of insulin resistance, islet dysfunction and glucose intolerance after high-fat feeding in mice overexpressing phosphodiesterase 3B.

Walz HA, Härndahl L, Wierup N, Zmuda-Trzebiatowska E, Svennelid F, Manganiello VC, Ploug T, Sundler F, Degerman E, Ahrén B, Holst LS.

J Endocrinol. 2006 Jun;189(3):629-41.


C(2)-ceramide influences the expression and insulin-mediated regulation of cyclic nucleotide phosphodiesterase 3B and lipolysis in 3T3-L1 adipocytes.

Mei J, Holst LS, Landström TR, Holm C, Brindley D, Manganiello V, Degerman E.

Diabetes. 2002 Mar;51(3):631-7.


Important role of phosphodiesterase 3B for the stimulatory action of cAMP on pancreatic beta-cell exocytosis and release of insulin.

Härndahl L, Jing XJ, Ivarsson R, Degerman E, Ahrén B, Manganiello VC, Renström E, Holst LS.

J Biol Chem. 2002 Oct 4;277(40):37446-55. Epub 2002 Aug 6.


Adipocyte-specific reduction of phosphodiesterase 3B gene expression and its restoration by JTT-501 in the obese, diabetic KKAy mouse.

Tang Y, Osawa H, Onuma H, Hasegawa M, Nishimiya T, Ochi M, Makino H.

Eur J Endocrinol. 2001 Jul;145(1):93-9.


Phosphodiesterase 3B gene expression is enhanced in the liver but reduced in the adipose tissue of obese insulin resistant db/db mouse.

Tang Y, Osawa H, Onuma H, Nishimiya T, Ochi M, Sugita A, Makino H.

Diabetes Res Clin Pract. 2001 Dec;54(3):145-55.


Differential function of the alpha2A-adrenoceptor and Phosphodiesterase-3B in human adipocytes of different origin.

Dicker A, Kaaman M, van Harmelen V, Aström G, Blanc KL, Rydén M.

Int J Obes (Lond). 2005 Dec;29(12):1413-21.


Role of PDE3B in insulin-induced glucose uptake, GLUT-4 translocation and lipogenesis in primary rat adipocytes.

Zmuda-Trzebiatowska E, Oknianska A, Manganiello V, Degerman E.

Cell Signal. 2006 Mar;18(3):382-90. Epub 2005 Jun 14.


Differential regulation of gene expression and insulin-induced activation of phosphodiesterase 3B in adipocytes of lean insulin-resistant IRS-1 (-/-) mice.

Hasegawa M, Tang Y, Osawa H, Onuma H, Nishimiya T, Ochi M, Terauchi Y, Kadowaki T, Makino H.

Diabetes Res Clin Pract. 2002 Nov;58(2):79-85.


Phosphorylation and activation of hormone-sensitive adipocyte phosphodiesterase type 3B.

Degerman E, Landström TR, Wijkander J, Holst LS, Ahmad F, Belfrage P, Manganiello V.

Methods. 1998 Jan;14(1):43-53.


Plasma membrane cyclic nucleotide phosphodiesterase 3B (PDE3B) is associated with caveolae in primary adipocytes.

Nilsson R, Ahmad F, Swärd K, Andersson U, Weston M, Manganiello V, Degerman E.

Cell Signal. 2006 Oct;18(10):1713-21. Epub 2006 Feb 28.


Leptin inhibits insulin secretion by activation of phosphodiesterase 3B.

Zhao AZ, Bornfeldt KE, Beavo JA.

J Clin Invest. 1998 Sep 1;102(5):869-73.


Multisite phosphorylation of adipocyte and hepatocyte phosphodiesterase 3B.

Lindh R, Ahmad F, Resjö S, James P, Yang JS, Fales HM, Manganiello V, Degerman E.

Biochim Biophys Acta. 2007 Apr;1773(4):584-92. Epub 2007 Jan 27.


Down-regulation of cyclic-nucleotide phosphodiesterase 3B in 3T3-L1 adipocytes induced by tumour necrosis factor alpha and cAMP.

Rahn Landström T, Mei J, Karlsson M, Manganiello V, Degerman E.

Biochem J. 2000 Mar 1;346 Pt 2:337-43.


Regulation of AMP-activated protein kinase by cAMP in adipocytes: roles for phosphodiesterases, protein kinase B, protein kinase A, Epac and lipolysis.

Omar B, Zmuda-Trzebiatowska E, Manganiello V, Göransson O, Degerman E.

Cell Signal. 2009 May;21(5):760-6. doi: 10.1016/j.cellsig.2009.01.015. Epub 2009 Jan 8.


Cyclic nucleotide phosphodiesterases in pancreatic islets.

Pyne NJ, Furman BL.

Diabetologia. 2003 Sep;46(9):1179-89. Epub 2003 Aug 7. Review.


Differential regulation of adipocyte PDE3B in distinct membrane compartments by insulin and the beta3-adrenergic receptor agonist CL316243: effects of caveolin-1 knockdown on formation/maintenance of macromolecular signalling complexes.

Ahmad F, Lindh R, Tang Y, Ruishalme I, Ost A, Sahachartsiri B, Strålfors P, Degerman E, Manganiello VC.

Biochem J. 2009 Dec 10;424(3):399-410. doi: 10.1042/BJ20090842.


Insulin-induced phosphorylation and activation of cyclic nucleotide phosphodiesterase 3B by the serine-threonine kinase Akt.

Kitamura T, Kitamura Y, Kuroda S, Hino Y, Ando M, Kotani K, Konishi H, Matsuzaki H, Kikkawa U, Ogawa W, Kasuga M.

Mol Cell Biol. 1999 Sep;19(9):6286-96.

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