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Items: 1 to 20 of 122


Mutant huntingtin inhibits clathrin-independent endocytosis and causes accumulation of cholesterol in vitro and in vivo.

Trushina E, Singh RD, Dyer RB, Cao S, Shah VH, Parton RG, Pagano RE, McMurray CT.

Hum Mol Genet. 2006 Dec 15;15(24):3578-91.


Loss of caveolin-1 expression in knock-in mouse model of Huntington's disease suppresses pathophysiology in vivo.

Trushina E, Canaria CA, Lee DY, McMurray CT.

Hum Mol Genet. 2014 Jan 1;23(1):129-44. doi: 10.1093/hmg/ddt406. Epub 2013 Sep 10.


Glycosphingolipids internalized via caveolar-related endocytosis rapidly merge with the clathrin pathway in early endosomes and form microdomains for recycling.

Sharma DK, Choudhury A, Singh RD, Wheatley CL, Marks DL, Pagano RE.

J Biol Chem. 2003 Feb 28;278(9):7564-72. Epub 2002 Dec 12.


Wild-type and mutant huntingtins function in vesicle trafficking in the secretory and endocytic pathways.

Velier J, Kim M, Schwarz C, Kim TW, Sapp E, Chase K, Aronin N, DiFiglia M.

Exp Neurol. 1998 Jul;152(1):34-40.


The adipocyte plasma membrane caveolin functional/structural organization is necessary for the efficient endocytosis of GLUT4.

Shigematsu S, Watson RT, Khan AH, Pessin JE.

J Biol Chem. 2003 Mar 21;278(12):10683-90. Epub 2002 Dec 20.


Selective caveolin-1-dependent endocytosis of glycosphingolipids.

Singh RD, Puri V, Valiyaveettil JT, Marks DL, Bittman R, Pagano RE.

Mol Biol Cell. 2003 Aug;14(8):3254-65. Epub 2003 May 18.


Clathrin-dependent and independent endocytosis of glucose transporter 4 (GLUT4) in myoblasts: regulation by mitochondrial uncoupling.

Antonescu CN, Díaz M, Femia G, Planas JV, Klip A.

Traffic. 2008 Jul;9(7):1173-90. doi: 10.1111/j.1600-0854.2008.00755.x. Epub 2008 Apr 24.


Endocytic crosstalk: cavins, caveolins, and caveolae regulate clathrin-independent endocytosis.

Chaudhary N, Gomez GA, Howes MT, Lo HP, McMahon KA, Rae JA, Schieber NL, Hill MM, Gaus K, Yap AS, Parton RG.

PLoS Biol. 2014 Apr 8;12(4):e1001832. doi: 10.1371/journal.pbio.1001832. eCollection 2014 Apr.


Expanded-polyglutamine huntingtin protein suppresses the secretion and production of a chemokine (CCL5/RANTES) by astrocytes.

Chou SY, Weng JY, Lai HL, Liao F, Sun SH, Tu PH, Dickson DW, Chern Y.

J Neurosci. 2008 Mar 26;28(13):3277-90. doi: 10.1523/JNEUROSCI.0116-08.2008.


Forskolin and dopamine D1 receptor activation increase huntingtin's association with endosomes in immortalized neuronal cells of striatal origin.

Kim M, Velier J, Chase K, Laforet G, Kalchman MA, Hayden MR, Won L, Heller A, Aronin N, Difiglia M.

Neuroscience. 1999;89(4):1159-67.


Expression of mutant N-terminal huntingtin fragment (htt552-100Q) in astrocytes suppresses the secretion of BDNF.

Wang L, Lin F, Wang J, Wu J, Han R, Zhu L, Difiglia M, Qin Z.

Brain Res. 2012 Apr 17;1449:69-82. doi: 10.1016/j.brainres.2012.01.077. Epub 2012 Feb 23.


Lack of huntingtin-associated protein-1 causes neuronal death resembling hypothalamic degeneration in Huntington's disease.

Li SH, Yu ZX, Li CL, Nguyen HP, Zhou YX, Deng C, Li XJ.

J Neurosci. 2003 Jul 30;23(17):6956-64.


Nature and cause of mitochondrial dysfunction in Huntington's disease: focusing on huntingtin and the striatum.

Oliveira JM.

J Neurochem. 2010 Jul;114(1):1-12. doi: 10.1111/j.1471-4159.2010.06741.x. Epub 2010 Apr 9. Review.


Pathological cell-cell interactions elicited by a neuropathogenic form of mutant Huntingtin contribute to cortical pathogenesis in HD mice.

Gu X, Li C, Wei W, Lo V, Gong S, Li SH, Iwasato T, Itohara S, Li XJ, Mody I, Heintz N, Yang XW.

Neuron. 2005 May 5;46(3):433-44.


Promoters are differentially sensitive to N-terminal mutant huntingtin-mediated transcriptional repression.

Hogel M, Laprairie RB, Denovan-Wright EM.

PLoS One. 2012;7(7):e41152. doi: 10.1371/journal.pone.0041152. Epub 2012 Jul 18.


Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro.

Trushina E, Dyer RB, Badger JD 2nd, Ure D, Eide L, Tran DD, Vrieze BT, Legendre-Guillemin V, McPherson PS, Mandavilli BS, Van Houten B, Zeitlin S, McNiven M, Aebersold R, Hayden M, Parisi JE, Seeberg E, Dragatsis I, Doyle K, Bender A, Chacko C, McMurray CT.

Mol Cell Biol. 2004 Sep;24(18):8195-209.


Clathrin- and caveolin-1-independent endocytosis: entry of simian virus 40 into cells devoid of caveolae.

Damm EM, Pelkmans L, Kartenbeck J, Mezzacasa A, Kurzchalia T, Helenius A.

J Cell Biol. 2005 Jan 31;168(3):477-88. Epub 2005 Jan 24.


Mutant huntingtin affects endocytosis in striatal cells by altering the binding of AP-2 to membranes.

Borgonovo JE, Troncoso M, Lucas JJ, Sosa MA.

Exp Neurol. 2013 Mar;241:75-83. doi: 10.1016/j.expneurol.2012.11.025. Epub 2012 Dec 5.


Capucin does not modify the toxicity of a mutant Huntingtin fragment in vivo.

Galvan L, Lepejová N, Gaillard MC, Malgorn C, Guillermier M, Houitte D, Bonvento G, Petit F, Dufour N, Héry P, Gérard M, Elalouf JM, Déglon N, Brouillet E, de Chaldée M.

Neurobiol Aging. 2012 Aug;33(8):1845.e5-6. doi: 10.1016/j.neurobiolaging.2012.01.009. Epub 2012 Feb 24.

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