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Results: 1 to 20 of 164

1.

Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1.

Guertin DA, Stevens DM, Thoreen CC, Burds AA, Kalaany NY, Moffat J, Brown M, Fitzgerald KJ, Sabatini DM.

Dev Cell. 2006 Dec;11(6):859-71.

PMID:
17141160
[PubMed - indexed for MEDLINE]
Free Article
2.

mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling.

Julien LA, Carriere A, Moreau J, Roux PP.

Mol Cell Biol. 2010 Feb;30(4):908-21. doi: 10.1128/MCB.00601-09. Epub 2009 Dec 7.

PMID:
19995915
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Receptor-recognized α₂-macroglobulin binds to cell surface-associated GRP78 and activates mTORC1 and mTORC2 signaling in prostate cancer cells.

Misra UK, Pizzo SV.

PLoS One. 2012;7(12):e51735. doi: 10.1371/journal.pone.0051735. Epub 2012 Dec 14.

PMID:
23272152
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

PRR5, a novel component of mTOR complex 2, regulates platelet-derived growth factor receptor beta expression and signaling.

Woo SY, Kim DH, Jun CB, Kim YM, Haar EV, Lee SI, Hegg JW, Bandhakavi S, Griffin TJ, Kim DH.

J Biol Chem. 2007 Aug 31;282(35):25604-12. Epub 2007 Jun 28.

PMID:
17599906
[PubMed - indexed for MEDLINE]
Free Article
5.

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1).

García-Martínez JM, Alessi DR.

Biochem J. 2008 Dec 15;416(3):375-85. doi: 10.1042/BJ20081668.

PMID:
18925875
[PubMed - indexed for MEDLINE]
Free Article
6.

Alcohol-induced modulation of rictor and mTORC2 activity in C2C12 myoblasts.

Hong-Brown LQ, Brown CR, Navaratnarajah M, Huber DS, Lang CH.

Alcohol Clin Exp Res. 2011 Aug;35(8):1445-53. doi: 10.1111/j.1530-0277.2011.01480.x. Epub 2011 Mar 25.

PMID:
21438886
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Raptor-rictor axis in TGFbeta-induced protein synthesis.

Das F, Ghosh-Choudhury N, Mahimainathan L, Venkatesan B, Feliers D, Riley DJ, Kasinath BS, Choudhury GG.

Cell Signal. 2008 Feb;20(2):409-23. Epub 2007 Nov 7.

PMID:
18068336
[PubMed - indexed for MEDLINE]
8.

Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability.

Shiota C, Woo JT, Lindner J, Shelton KD, Magnuson MA.

Dev Cell. 2006 Oct;11(4):583-9. Epub 2006 Sep 7.

PMID:
16962829
[PubMed - indexed for MEDLINE]
Free Article
9.

Syndecan-4 regulates subcellular localization of mTOR Complex2 and Akt activation in a PKCalpha-dependent manner in endothelial cells.

Partovian C, Ju R, Zhuang ZW, Martin KA, Simons M.

Mol Cell. 2008 Oct 10;32(1):140-9. doi: 10.1016/j.molcel.2008.09.010.

PMID:
18851840
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1.

Dibble CC, Asara JM, Manning BD.

Mol Cell Biol. 2009 Nov;29(21):5657-70. doi: 10.1128/MCB.00735-09. Epub 2009 Aug 31.

PMID:
19720745
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney.

Pearce LR, Sommer EM, Sakamoto K, Wullschleger S, Alessi DR.

Biochem J. 2011 May 15;436(1):169-79. doi: 10.1042/BJ20102103.

PMID:
21413931
[PubMed - indexed for MEDLINE]
Free Article
12.

Identification of Akt-independent regulation of hepatic lipogenesis by mammalian target of rapamycin (mTOR) complex 2.

Yuan M, Pino E, Wu L, Kacergis M, Soukas AA.

J Biol Chem. 2012 Aug 24;287(35):29579-88. doi: 10.1074/jbc.M112.386854. Epub 2012 Jul 7.

PMID:
22773877
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Identification of Protor as a novel Rictor-binding component of mTOR complex-2.

Pearce LR, Huang X, Boudeau J, Pawłowski R, Wullschleger S, Deak M, Ibrahim AF, Gourlay R, Magnuson MA, Alessi DR.

Biochem J. 2007 Aug 1;405(3):513-22.

PMID:
17461779
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy.

Bentzinger CF, Romanino K, Cloëtta D, Lin S, Mascarenhas JB, Oliveri F, Xia J, Casanova E, Costa CF, Brink M, Zorzato F, Hall MN, Rüegg MA.

Cell Metab. 2008 Nov;8(5):411-24. doi: 10.1016/j.cmet.2008.10.002.

PMID:
19046572
[PubMed - indexed for MEDLINE]
Free Article
15.

mTORC1 and mTORC2 regulate insulin secretion through Akt in INS-1 cells.

Le Bacquer O, Queniat G, Gmyr V, Kerr-Conte J, Lefebvre B, Pattou F.

J Endocrinol. 2013 Jan 2;216(1):21-9. doi: 10.1530/JOE-12-0351. Print 2013 Jan.

PMID:
23092880
[PubMed - indexed for MEDLINE]
Free Article
16.

SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity.

Jacinto E, Facchinetti V, Liu D, Soto N, Wei S, Jung SY, Huang Q, Qin J, Su B.

Cell. 2006 Oct 6;127(1):125-37. Epub 2006 Sep 7.

PMID:
16962653
[PubMed - indexed for MEDLINE]
Free Article
17.

Hypoxia-induced endothelial proliferation requires both mTORC1 and mTORC2.

Li W, Petrimpol M, Molle KD, Hall MN, Battegay EJ, Humar R.

Circ Res. 2007 Jan 5;100(1):79-87. Epub 2006 Nov 16.

PMID:
17110594
[PubMed - indexed for MEDLINE]
Free Article
18.

Upregulation of mTORC2 activation by the selective agonist of EPAC, 8-CPT-2Me-cAMP, in prostate cancer cells: assembly of a multiprotein signaling complex.

Misra UK, Pizzo SV.

J Cell Biochem. 2012 May;113(5):1488-500. doi: 10.1002/jcb.24018.

PMID:
22173835
[PubMed - indexed for MEDLINE]
19.

mTORC2 is required for proliferation and survival of TSC2-null cells.

Goncharova EA, Goncharov DA, Li H, Pimtong W, Lu S, Khavin I, Krymskaya VP.

Mol Cell Biol. 2011 Jun;31(12):2484-98. doi: 10.1128/MCB.01061-10. Epub 2011 Apr 11.

PMID:
21482669
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

mTOR-rictor is the Ser473 kinase for AKT1 in mouse one-cell stage embryos.

Zhang Z, Zhang G, Xu X, Su W, Yu B.

Mol Cell Biochem. 2012 Feb;361(1-2):249-57. doi: 10.1007/s11010-011-1110-0. Epub 2011 Nov 5.

PMID:
22057724
[PubMed - indexed for MEDLINE]

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