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Results: 1 to 20 of 191

1.

Synthesis of novel quinolone and quinoline-2-carboxylic acid (4-morpholin-4-yl-phenyl)amides: a late-stage diversification approach to potent 5HT1B antagonists.

Horchler CL, McCauley JP Jr, Hall JE, Snyder DH, Craig Moore W, Hudzik TJ, Chapdelaine MJ.

Bioorg Med Chem. 2007 Jan 15;15(2):939-50. Epub 2006 Oct 20.

PMID:
17126021
[PubMed - indexed for MEDLINE]
2.

[N-methyl-3H3]AZ10419369 binding to the 5-HT1B receptor: in vitro characterization and in vivo receptor occupancy.

Maier DL, Sobotka-Briner C, Ding M, Powell ME, Jiang Q, Hill G, Heys JR, Elmore CS, Pierson ME, Mrzljak L.

J Pharmacol Exp Ther. 2009 Jul;330(1):342-51. doi: 10.1124/jpet.109.150722. Epub 2009 Apr 28.

PMID:
19401496
[PubMed - indexed for MEDLINE]
Free Article
3.

Potent antagonists of gonadotropin releasing hormone receptors derived from quinolone-6-carboxamides.

Walsh TF, Toupence RB, Young JR, Huang SX, Ujjainwalla F, DeVita RJ, Goulet MT, Wyvratt MJ Jr, Fisher MH, Lo JL, Ren N, Yudkovitz JB, Yang YT, Cheng K, Smith RG.

Bioorg Med Chem Lett. 2000 Mar 6;10(5):443-7.

PMID:
10743944
[PubMed - indexed for MEDLINE]
4.
5.

Benzoxazines. II. Synthesis, conformational analysis, and structure--activity relationships of 3,4-dihydro-2H-1,4-benzoxazine-8-carboxamide derivatives as potent and long-acting serotonin-3 (5-HT3) receptor antagonists.

Kuroita T, Marubayashi N, Sano M, Kanzaki K, Inaba K, Kawakita T.

Chem Pharm Bull (Tokyo). 1996 Nov;44(11):2051-60.

PMID:
8945770
[PubMed - indexed for MEDLINE]
6.

Quinolone carboxylic acids as a novel monoketo acid class of human immunodeficiency virus type 1 integrase inhibitors.

Sato M, Kawakami H, Motomura T, Aramaki H, Matsuda T, Yamashita M, Ito Y, Matsuzaki Y, Yamataka K, Ikeda S, Shinkai H.

J Med Chem. 2009 Aug 13;52(15):4869-82. doi: 10.1021/jm900460z.

PMID:
19719237
[PubMed - indexed for MEDLINE]
7.
8.

Kynurenic acid amides as novel NR2B selective NMDA receptor antagonists.

Borza I, Kolok S, Galgóczy K, Gere A, Horváth C, Farkas S, Greiner I, Domány G.

Bioorg Med Chem Lett. 2007 Jan 15;17(2):406-9. Epub 2006 Oct 17.

PMID:
17074483
[PubMed - indexed for MEDLINE]
9.

Synthesis and SAR studies of 2-oxoquinoline derivatives as CB2 receptor inverse agonists.

Raitio KH, Savinainen JR, Vepsäläinen J, Laitinen JT, Poso A, Järvinen T, Nevalainen T.

J Med Chem. 2006 Mar 23;49(6):2022-7.

PMID:
16539390
[PubMed - indexed for MEDLINE]
10.

[11C]AZ10419369: a selective 5-HT1B receptor radioligand suitable for positron emission tomography (PET). Characterization in the primate brain.

Pierson ME, Andersson J, Nyberg S, McCarthy DJ, Finnema SJ, Varnäs K, Takano A, Karlsson P, Gulyás B, Medd AM, Lee CM, Powell ME, Heys JR, Potts W, Seneca N, Mrzljak L, Farde L, Halldin C.

Neuroimage. 2008 Jul 1;41(3):1075-85. doi: 10.1016/j.neuroimage.2008.02.063. Epub 2008 Mar 14.

PMID:
18434202
[PubMed - indexed for MEDLINE]
11.

Synthesis and biological relationships of 3',6-substituted 2-phenyl-4-quinolone-3-carboxylic acid derivatives as antimitotic agents.

Lai YY, Huang LJ, Lee KH, Xiao Z, Bastow KF, Yamori T, Kuo SC.

Bioorg Med Chem. 2005 Jan 3;13(1):265-75.

PMID:
15582470
[PubMed - indexed for MEDLINE]
12.

Pyrazolo[1,5-a]pyrimidin-7-yl phenyl amides as novel antiproliferative agents: exploration of core and headpiece structure-activity relationships.

Powell D, Gopalsamy A, Wang YD, Zhang N, Miranda M, McGinnis JP, Rabindran SK.

Bioorg Med Chem Lett. 2007 Mar 15;17(6):1641-5. Epub 2007 Jan 13.

PMID:
17275298
[PubMed - indexed for MEDLINE]
13.

Diaryl dihydropyrazole-3-carboxamides with significant in vivo antiobesity activity related to CB1 receptor antagonism: synthesis, biological evaluation, and molecular modeling in the homology model.

Srivastava BK, Joharapurkar A, Raval S, Patel JZ, Soni R, Raval P, Gite A, Goswami A, Sadhwani N, Gandhi N, Patel H, Mishra B, Solanki M, Pandey B, Jain MR, Patel PR.

J Med Chem. 2007 Nov 29;50(24):5951-66. Epub 2007 Nov 3.

PMID:
17979261
[PubMed - indexed for MEDLINE]
14.

Synthesis and antibacterial activity of 7-(1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-7-yl) quinolones.

Zhu B, Marinelli BA, Goldschmidt R, Foleno BD, Hilliard JJ, Bush K, Macielag MJ.

Bioorg Med Chem Lett. 2009 Sep 1;19(17):4933-6. doi: 10.1016/j.bmcl.2009.07.087. Epub 2009 Jul 22.

PMID:
19646867
[PubMed - indexed for MEDLINE]
15.

Parallel synthesis and dopamine D3/D2 receptor screening of novel {4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl}carboxamides.

Heidler P, Zohrabi-Kalantari V, Calmels T, Capet M, Berrebi-Bertrand I, Schwartz JC, Stark H, Link A.

Bioorg Med Chem. 2005 Mar 15;13(6):2009-14.

PMID:
15727854
[PubMed - indexed for MEDLINE]
17.

Identification of a novel series of selective 5-HT7 receptor antagonists.

Forbes IT, Cooper DG, Dodds EK, Douglas SE, Gribble AD, Ife RJ, Lightfoot AP, Meeson M, Campbell LP, Coleman T, Riley GJ, Thomas DR.

Bioorg Med Chem Lett. 2003 Mar 24;13(6):1055-8.

PMID:
12643910
[PubMed - indexed for MEDLINE]
18.

Synthesis and structure-activity relationships of biarylcarboxamide bis-aminopyrrolidine urea derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1).

Rowbottom MW, Vickers TD, Dyck B, Tamiya J, Zhang M, Zhao L, Grey J, Provencal D, Schwarz D, Heise CE, Mistry M, Fisher A, Dong T, Hu T, Saunders J, Goodfellow VS.

Bioorg Med Chem Lett. 2005 Jul 15;15(14):3439-45.

PMID:
15950467
[PubMed - indexed for MEDLINE]
19.

Synthesis of 6-hydroxy-7-methoxy-4-oxo-4H-chromene-2-carboxylic acid N-alkyl amides and their antioxidant activity.

Cho J, Kang HE, Jung JK, Lee H.

Arch Pharm Res. 2006 Mar;29(3):183-7.

PMID:
16596987
[PubMed - indexed for MEDLINE]
20.

Synthesis and antiplatelet activity of phenyl quinolones.

Huang LJ, Hsieh MC, Teng CM, Lee KH, Kuo SC.

Bioorg Med Chem. 1998 Oct;6(10):1657-62.

PMID:
9838997
[PubMed - indexed for MEDLINE]

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