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Results: 1 to 20 of 223

1.

Structure-activity relationships of 19-norvitamin D analogs having a fluoroethylidene group at the C-2 position.

Kobayashi E, Shimazaki M, Miyamoto Y, Masuno H, Yamamoto K, DeLuca HF, Yamada S, Shimizu M.

Bioorg Med Chem. 2007 Feb 1;15(3):1475-82. Epub 2006 Nov 3.

PMID:
17110116
[PubMed - indexed for MEDLINE]
2.

Analogs of 1alpha,25-dihydroxyvitamin D3 with high potency in induction of osteoclastogenesis and prevention of dendritic cell differentiation: synthesis and biological evaluation of 2-substituted 19-norvitamin D analogs.

Shimazaki M, Miyamoto Y, Yamamoto K, Yamada S, Takami M, Shinki T, Udagawa N, Shimizu M.

Bioorg Med Chem. 2006 Jul 1;14(13):4645-56. Epub 2006 Mar 2.

PMID:
16513359
[PubMed - indexed for MEDLINE]
3.

Synthesis and structure-activity relationships of 16-ene-22-thia-1alpha,25-dihydroxy-26,27-dimethyl-19-norvitamin D3 analogs having side chains of different sizes.

Takaku H, Miyamoto Y, Asami S, Shimazaki M, Yamada S, Yamamoto K, Udagawa N, DeLuca HF, Shimizu M.

Bioorg Med Chem. 2008 Feb 15;16(4):1796-815. Epub 2007 Nov 6.

PMID:
18032055
[PubMed - indexed for MEDLINE]
4.

Synthesis and biological activities of new 1alpha,25-dihydroxy-19-norvitamin D3 analogs with modifications in both the A-ring and the side chain.

Shimizu M, Miyamoto Y, Kobayashi E, Shimazaki M, Yamamoto K, Reischl W, Yamada S.

Bioorg Med Chem. 2006 Jun 15;14(12):4277-94. Epub 2006 Feb 24.

PMID:
16503143
[PubMed - indexed for MEDLINE]
5.

New derivatives of 1alpha,25-dihydroxy-19-norvitamin D3 with two substituents at C-2: synthesis and biological activity.

Shimizu M, Iwasaki Y, Shimazaki M, Amano Y, Yamamoto K, Reischl W, Yamada S.

Bioorg Med Chem Lett. 2005 Mar 1;15(5):1451-5.

PMID:
15713405
[PubMed - indexed for MEDLINE]
6.

2-Ethyl and 2-ethylidene analogues of 1alpha,25-dihydroxy-19-norvitamin D(3): synthesis, conformational analysis, biological activities, and docking to the modeled rVDR ligand binding domain.

Sicinski RR, Rotkiewicz P, Kolinski A, Sicinska W, Prahl JM, Smith CM, DeLuca HF.

J Med Chem. 2002 Aug 1;45(16):3366-80.

PMID:
12139448
[PubMed - indexed for MEDLINE]
7.

2-Substituted-16-ene-22-thia-1alpha,25-dihydroxy-26,27-dimethyl-19-norvitamin D3 analogs: Synthesis, biological evaluation, and crystal structure.

Shimizu M, Miyamoto Y, Takaku H, Matsuo M, Nakabayashi M, Masuno H, Udagawa N, DeLuca HF, Ikura T, Ito N.

Bioorg Med Chem. 2008 Jul 15;16(14):6949-64. doi: 10.1016/j.bmc.2008.05.043. Epub 2008 May 27.

PMID:
18539034
[PubMed - indexed for MEDLINE]
8.

13-Methyl-substituted des-C,D analogs of (20S)-1alpha,25-dihydroxy-2-methylene-19-norvitamin D3 (2MD): synthesis and biological evaluation.

Plonska-Ocypa K, Sicinski RR, Plum LA, Grzywacz P, Frelek J, Clagett-Dame M, DeLuca HF.

Bioorg Med Chem. 2009 Feb 15;17(4):1747-63. doi: 10.1016/j.bmc.2008.11.082. Epub 2008 Dec 10.

PMID:
19167893
[PubMed - indexed for MEDLINE]
9.

2-Methylene analogs of 1alpha-hydroxy-19-norvitamin D3: synthesis, biological activities and docking to the ligand binding domain of the rat vitamin D receptor.

Grzywacz P, Plum LA, Sicinska W, Sicinski RR, Prahl JM, DeLuca HF.

J Steroid Biochem Mol Biol. 2004 May;89-90(1-5):13-7.

PMID:
15225739
[PubMed - indexed for MEDLINE]
10.

Natural metabolites of 1alpha,25-dihydroxyvitamin D(3) retain biologic activity mediated through the vitamin D receptor.

Harant H, Spinner D, Reddy GS, Lindley IJ.

J Cell Biochem. 2000 Apr;78(1):112-20.

PMID:
10797570
[PubMed - indexed for MEDLINE]
11.

New 1alpha,25-dihydroxy-19-norvitamin D3 compounds of high biological activity: synthesis and biological evaluation of 2-hydroxymethyl, 2-methyl, and 2-methylene analogues.

Sicinski RR, Prahl JM, Smith CM, DeLuca HF.

J Med Chem. 1998 Nov 5;41(23):4662-74.

PMID:
9804706
[PubMed - indexed for MEDLINE]
13.

Gene regulatory potential of 1alpha,25-dihydroxyvitamin D(3) analogues with two side chains.

Bury Y, Herdick M, Uskokovic MR, Carlberg C.

J Cell Biochem Suppl. 2001;Suppl 36:179-90.

PMID:
11455583
[PubMed - indexed for MEDLINE]
14.

13,13-Dimethyl-des-C,D analogues of (20S)-1α,25-dihydroxy-2-methylene-19-norvitamin D₃ (2MD): total synthesis, docking to the VDR, and biological evaluation.

Plonska-Ocypa K, Sibilska I, Sicinski RR, Sicinska W, Plum LA, DeLuca HF.

Bioorg Med Chem. 2011 Dec 1;19(23):7205-20. doi: 10.1016/j.bmc.2011.09.048. Epub 2011 Oct 2.

PMID:
22018918
[PubMed - indexed for MEDLINE]
15.

New analogs of 2-methylene-19-nor-(20S)-1,25-dihydroxyvitamin D3 with conformationally restricted side chains: evaluation of biological activity and structural determination of VDR-bound conformations.

Vanhooke JL, Tadi BP, Benning MM, Plum LA, DeLuca HF.

Arch Biochem Biophys. 2007 Apr 15;460(2):161-5. Epub 2006 Dec 12.

PMID:
17227670
[PubMed - indexed for MEDLINE]
16.

2-(3'-Hydroxypropylidene)-1alpha-hydroxy-19-norvitamin D compounds with truncated side chains.

Glebocka A, Sicinski RR, Plum LA, DeLuca HF.

J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):310-5. Epub 2007 Jan 16.

PMID:
17223340
[PubMed - indexed for MEDLINE]
17.

New 2-alkylidene 1alpha,25-dihydroxy-19-norvitamin D3 analogues of high intestinal activity: synthesis and biological evaluation of 2-(3'-alkoxypropylidene) and 2-(3'-hydroxypropylidene) derivatives.

Glebocka A, Sicinski RR, Plum LA, Clagett-Dame M, DeLuca HF.

J Med Chem. 2006 May 18;49(10):2909-20.

PMID:
16686534
[PubMed - indexed for MEDLINE]
18.

Synthesis and biological evaluation of a des-C,D-analog of 2-methylene-19-nor-1alpha,25-(OH)2D3.

Plonska-Ocypa K, Grzywacz P, Sicinski RR, Plum LA, DeLuca HF.

J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):298-304. Epub 2007 Jan 16.

PMID:
17223343
[PubMed - indexed for MEDLINE]
19.

New derivative of 1alpha,25-dihydroxy-19-norvitamin D3 with 3'-alkoxypropylidene moiety at C-2: synthesis, biological activity and conformational analysis.

Glebocka A, Sicinski RR, DeLuca HF.

J Steroid Biochem Mol Biol. 2004 May;89-90(1-5):25-30.

PMID:
15225741
[PubMed - indexed for MEDLINE]
20.

An analog of 1alpha,25-dihydroxy-19-norvitamin D3 with the 1alpha-hydroxy group fixed in the axial position lacks biological activity in vitro.

Sicinski RR, Glebocka A, Plum LA, DeLuca HF.

J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):293-7. Epub 2007 Jan 12.

PMID:
17223547
[PubMed - indexed for MEDLINE]

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