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Items: 1 to 20 of 55

1.

Diminished lifespan and acute stress-induced death in DNA-PKcs-deficient mice with limiting telomeres.

Wong KK, Maser RS, Sahin E, Bailey ST, Xia H, Ji H, McNamara K, Naylor M, Bronson RT, Ghosh S, Welsh R, DePinho RA.

Oncogene. 2007 May 3;26(20):2815-21. Epub 2006 Oct 30.

PMID:
17072335
2.

DNA-dependent protein kinase catalytic subunit is not required for dysfunctional telomere fusion and checkpoint response in the telomerase-deficient mouse.

Maser RS, Wong KK, Sahin E, Xia H, Naylor M, Hedberg HM, Artandi SE, DePinho RA.

Mol Cell Biol. 2007 Mar;27(6):2253-65. Epub 2006 Dec 4.

3.

Functional interaction between DNA-PKcs and telomerase in telomere length maintenance.

Espejel S, Franco S, Sgura A, Gae D, Bailey SM, Taccioli GE, Blasco MA.

EMBO J. 2002 Nov 15;21(22):6275-87.

4.

53BP1 mediates the fusion of mammalian telomeres rendered dysfunctional by DNA-PKcs loss or inhibition.

Rybanska-Spaeder I, Ghosh R, Franco S.

PLoS One. 2014 Sep 29;9(9):e108731. doi: 10.1371/journal.pone.0108731. eCollection 2014.

5.

Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation.

Choudhury AR, Ju Z, Djojosubroto MW, Schienke A, Lechel A, Schaetzlein S, Jiang H, Stepczynska A, Wang C, Buer J, Lee HW, von Zglinicki T, Ganser A, Schirmacher P, Nakauchi H, Rudolph KL.

Nat Genet. 2007 Jan;39(1):99-105. Epub 2006 Dec 3.

PMID:
17143283
6.

Regulatory roles of tankyrase 1 at telomeres and in DNA repair: suppression of T-SCE and stabilization of DNA-PKcs.

Dregalla RC, Zhou J, Idate RR, Battaglia CL, Liber HL, Bailey SM.

Aging (Albany NY). 2010 Oct;2(10):691-708.

7.

Telomere dysfunction and DNA-PKcs deficiency: characterization and consequence.

Williams ES, Klingler R, Ponnaiya B, Hardt T, Schrock E, Lees-Miller SP, Meek K, Ullrich RL, Bailey SM.

Cancer Res. 2009 Mar 1;69(5):2100-7. doi: 10.1158/0008-5472.CAN-08-2854. Epub 2009 Feb 24.

8.

Shorter telomeres, accelerated ageing and increased lymphoma in DNA-PKcs-deficient mice.

Espejel S, Martín M, Klatt P, Martín-Caballero J, Flores JM, Blasco MA.

EMBO Rep. 2004 May;5(5):503-9. Epub 2004 Apr 23.

9.

Impact of telomerase ablation on organismal viability, aging, and tumorigenesis in mice lacking the DNA repair proteins PARP-1, Ku86, or DNA-PKcs.

Espejel S, Klatt P, Ménissier-de Murcia J, Martín-Caballero J, Flores JM, Taccioli G, de Murcia G, Blasco MA.

J Cell Biol. 2004 Nov 22;167(4):627-38. Epub 2004 Nov 15.

10.

Shortened telomeres in murine scid cells expressing mutant hRAD54 coincide with reduction in recombination at telomeres.

Al-Wahiby S, Wong HP, Slijepcevic P.

Mutat Res. 2005 Oct 15;578(1-2):134-42. Epub 2005 Jun 21.

PMID:
15975611
11.

Rad51 and DNA-PKcs are involved in the generation of specific telomere aberrations induced by the quadruplex ligand 360A that impair mitotic cell progression and lead to cell death.

Gauthier LR, Granotier C, Hoffschir F, Etienne O, Ayouaz A, Desmaze C, Mailliet P, Biard DS, Boussin FD.

Cell Mol Life Sci. 2012 Feb;69(4):629-40. doi: 10.1007/s00018-011-0767-6. Epub 2011 Jul 20.

12.

The progeroid phenotype of Ku80 deficiency is dominant over DNA-PKCS deficiency.

Reiling E, Dollé ME, Youssef SA, Lee M, Nagarajah B, Roodbergen M, de With P, de Bruin A, Hoeijmakers JH, Vijg J, van Steeg H, Hasty P.

PLoS One. 2014 Apr 16;9(4):e93568. doi: 10.1371/journal.pone.0093568. eCollection 2014.

13.

DNA-PKcs and Artemis function in the end-joining phase of immunoglobulin heavy chain class switch recombination.

Franco S, Murphy MM, Li G, Borjeson T, Boboila C, Alt FW.

J Exp Med. 2008 Mar 17;205(3):557-64. doi: 10.1084/jem.20080044. Epub 2008 Mar 3.

14.

Identification of telomere-dependent "senescence-like" arrest in mouse embryonic fibroblasts.

Espejel S, Blasco MA.

Exp Cell Res. 2002 Jun 10;276(2):242-8.

PMID:
12027454
15.

Ku70 stimulates fusion of dysfunctional telomeres yet protects chromosome ends from homologous recombination.

Celli GB, Denchi EL, de Lange T.

Nat Cell Biol. 2006 Aug;8(8):885-90. Epub 2006 Jul 16.

PMID:
16845382
16.

Dysfunctional mammalian telomeres join with DNA double-strand breaks.

Bailey SM, Cornforth MN, Ullrich RL, Goodwin EH.

DNA Repair (Amst). 2004 Apr 1;3(4):349-57.

PMID:
15010310
17.

Impaired telomerase activity in human cells expressing GFP-Ku86 fusion proteins.

Badie C, Yáñez-Muñoz RJ, Muller C, Salles B, Porter AC.

Cytogenet Genome Res. 2008;122(3-4):326-35. doi: 10.1159/000167819. Epub 2009 Jan 30.

PMID:
19188702
18.

DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion.

Celli GB, de Lange T.

Nat Cell Biol. 2005 Jul;7(7):712-8. Epub 2005 Jun 19.

PMID:
15968270
19.

Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1.

Denchi EL, de Lange T.

Nature. 2007 Aug 30;448(7157):1068-71. Epub 2007 Aug 8.

PMID:
17687332
20.

Telomere-mediated chromosomal instability triggers TLR4 induced inflammation and death in mice.

Bhattacharjee RN, Banerjee B, Akira S, Hande MP.

PLoS One. 2010 Jul 29;5(7):e11873. doi: 10.1371/journal.pone.0011873.

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