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Items: 1 to 20 of 536

1.

AZT and AZT-monophosphate prodrugs incorporating HIV-protease substrate fragment: synthesis and evaluation as specific drug delivery systems.

Liotard JF, Mehiri M, Di Giorgio A, Boggetto N, Reboud-Ravaux M, Aubertin AM, Condom R, Patino N.

Antivir Chem Chemother. 2006;17(4):193-213.

PMID:
17066898
2.
3.
4.

Intracellular metabolism of CycloSaligenyl 3'-azido-2', 3'-dideoxythymidine monophosphate, a prodrug of 3'-azido-2', 3'-dideoxythymidine (zidovudine).

Balzarini J, Naesens L, Aquaro S, Knispel T, Perno C, De Clercq E, Meier C.

Mol Pharmacol. 1999 Dec;56(6):1354-61.

5.

Cellular metabolism in lymphocytes of a novel thioether-phospholipid-AZT conjugate with anti-HIV-1 activity.

Kucera GL, Goff CL, Iyer N, Morris-Natschke S, Ishaq KS, Wyrick SD, Fleming RA, Kucera LS.

Antiviral Res. 2001 May;50(2):129-37.

PMID:
11369433
6.

Novel approaches for designing 5'-O-ester prodrugs of 3'-azido-2', 3'-dideoxythymidine (AZT).

Parang K, Wiebe LI, Knaus EE.

Curr Med Chem. 2000 Oct;7(10):995-1039. Review.

PMID:
10911016
7.

Characterization of the activation pathway of phosphoramidate triester prodrugs of stavudine and zidovudine.

Saboulard D, Naesens L, Cahard D, Salgado A, Pathirana R, Velazquez S, McGuigan C, De Clercq E, Balzarini J.

Mol Pharmacol. 1999 Oct;56(4):693-704.

8.

Dipeptide derivatives of AZT: synthesis, chemical stability, activation in human plasma, hPEPT1 affinity, and antiviral activity.

Santos C, Morais J, Gouveia L, de Clercq E, Pannecouque C, Nielsen CU, Steffansen B, Moreira R, Gomes P.

ChemMedChem. 2008 Jun;3(6):970-8. doi: 10.1002/cmdc.200800012.

PMID:
18389514
10.

Synthesis, anti-HIV activity, and stability studies of 5'-phosphorofluoridate derivatives of AZT.

Egron D, Arzumanov AA, Dyatkina NB, Aubertin AM, Imbach JL, Gosselin G, Krayevsky A, Périgaud C.

Bioorg Chem. 2001 Dec;29(6):333-44.

PMID:
11846432
11.

5'-Hydrogenphosphonates of anti-HIV nucleoside analogues revisited: controversial mode of action.

Gosselin G, Périgaud C, Lefebvre I, Pompon A, Aubertin AM, Kirn A, Szabo T, Stawinski J, Imbach JL.

Antiviral Res. 1993 Oct;22(2-3):143-53.

PMID:
8279809
12.

New 3'-azido-3'-deoxythymidin-5'-yl O-(omega-hydroxyalkyl) carbonate prodrugs: synthesis and anti-HIV evaluation.

Vlieghe P, Bihel F, Clerc T, Pannecouque C, Witvrouw M, De Clercq E, Salles JP, Chermann JC, Kraus JL.

J Med Chem. 2001 Mar 1;44(5):777-86.

PMID:
11262088
13.

Low-dose, sublingual AZT-monophosphate therapy for HIV+ patients?

Johnson S.

Med Hypotheses. 2001 Mar;56(3):409-10.

PMID:
11359372
14.

Anti-HIV pronucleotides: decomposition pathways and correlation with biological activities.

Egron D, Lefebvre I, Périgaud C, Beltran T, Pompon A, Gosselin G, Aubertin AM, Imbach JL.

Bioorg Med Chem Lett. 1998 May 5;8(9):1045-50.

PMID:
9871705
15.

Synthesis and anti-HIV evaluation of some phosphoramidate derivatives of AZT: studies on the effect of chain elongation on biological activity.

Curley D, McGuigan C, Devine KG, O'Connor TJ, Jeffries DJ, Kinchington D.

Antiviral Res. 1990 Dec;14(6):345-56.

PMID:
2088210
16.

Targeting of antiviral drugs to T4-lymphocytes. Anti-HIV activity of neoglycoprotein-AZTMP conjugates in vitro.

Molema G, Jansen RW, Pauwels R, de Clercq E, Meijer DK.

Biochem Pharmacol. 1990 Dec 15;40(12):2603-10.

PMID:
1979734
18.

S-Acyl-2-thioethyl aryl phosphotriester derivatives as mononucleotide prodrugs.

Schlienger N, Peyrottes S, Kassem T, Imbach JL, Gosselin G, Aubertin AM, Périgaud C.

J Med Chem. 2000 Nov 16;43(23):4570-4.

PMID:
11087582
19.

Thymidine and zidovudine metabolism in chronically zidovudine-exposed cells in vitro.

Agarwal RP, Mian AM.

Biochem Pharmacol. 1991 Jul 25;42(4):905-11.

PMID:
1867645
20.

Synthesis and antiviral activity of 3'-azido-3'-deoxythymidine triphosphate distearoylglycerol: a novel phospholipid conjugate of the anti-HIV agent AZT.

van Wijk GM, Hostetler KY, Kroneman E, Richman DD, Sridhar CN, Kumar R, van den Bosch H.

Chem Phys Lipids. 1994 Apr 19;70(2):213-22.

PMID:
8033292
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