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Results: 1 to 20 of 203

1.

Structural and dynamical changes in an alpha-subunit of a heterotrimeric G protein along the activation pathway.

Van Eps N, Oldham WM, Hamm HE, Hubbell WL.

Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16194-9. Epub 2006 Oct 19.

PMID:
17053066
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Conformational changes in the amino-terminal helix of the G protein alpha(i1) following dissociation from Gbetagamma subunit and activation.

Medkova M, Preininger AM, Yu NJ, Hubbell WL, Hamm HE.

Biochemistry. 2002 Aug 6;41(31):9962-72.

PMID:
12146960
[PubMed - indexed for MEDLINE]
3.

Mapping allosteric connections from the receptor to the nucleotide-binding pocket of heterotrimeric G proteins.

Oldham WM, Van Eps N, Preininger AM, Hubbell WL, Hamm HE.

Proc Natl Acad Sci U S A. 2007 May 8;104(19):7927-32. Epub 2007 Apr 26.

PMID:
17463080
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Structural basis of effector regulation and signal termination in heterotrimeric Galpha proteins.

Sprang SR, Chen Z, Du X.

Adv Protein Chem. 2007;74:1-65. Review.

PMID:
17854654
[PubMed - indexed for MEDLINE]
5.

Structural basis of activity and subunit recognition in G protein heterotrimers.

Wall MA, Posner BA, Sprang SR.

Structure. 1998 Sep 15;6(9):1169-83.

PMID:
9753695
[PubMed - indexed for MEDLINE]
6.

Heterotrimeric G-protein alpha-subunit adopts a "preactivated" conformation when associated with betagamma-subunits.

Abdulaev NG, Ngo T, Zhang C, Dinh A, Brabazon DM, Ridge KD, Marino JP.

J Biol Chem. 2005 Nov 11;280(45):38071-80. Epub 2005 Aug 29.

PMID:
16129667
[PubMed - indexed for MEDLINE]
Free Article
7.

The receptor-bound "empty pocket" state of the heterotrimeric G-protein alpha-subunit is conformationally dynamic.

Abdulaev NG, Ngo T, Ramon E, Brabazon DM, Marino JP, Ridge KD.

Biochemistry. 2006 Oct 31;45(43):12986-97.

PMID:
17059215
[PubMed - indexed for MEDLINE]
8.

Structure of the GDP-Pi complex of Gly203-->Ala gialpha1: a mimic of the ternary product complex of galpha-catalyzed GTP hydrolysis.

Berghuis AM, Lee E, Raw AS, Gilman AG, Sprang SR.

Structure. 1996 Nov 15;4(11):1277-90.

PMID:
8939752
[PubMed - indexed for MEDLINE]
10.

Structural basis of function in heterotrimeric G proteins.

Oldham WM, Hamm HE.

Q Rev Biophys. 2006 May;39(2):117-66. Epub 2006 Aug 21. Review.

PMID:
16923326
[PubMed - indexed for MEDLINE]
11.

Molecular basis for interactions of G protein betagamma subunits with effectors.

Ford CE, Skiba NP, Bae H, Daaka Y, Reuveny E, Shekter LR, Rosal R, Weng G, Yang CS, Iyengar R, Miller RJ, Jan LY, Lefkowitz RJ, Hamm HE.

Science. 1998 May 22;280(5367):1271-4.

PMID:
9596582
[PubMed - indexed for MEDLINE]
Free Article
12.

Structural evidence for a sequential release mechanism for activation of heterotrimeric G proteins.

Kapoor N, Menon ST, Chauhan R, Sachdev P, Sakmar TP.

J Mol Biol. 2009 Nov 6;393(4):882-97. doi: 10.1016/j.jmb.2009.08.043. Epub 2009 Aug 22.

PMID:
19703466
[PubMed - indexed for MEDLINE]
13.

Gbetagamma inhibits Galpha GTPase-activating proteins by inhibition of Galpha-GTP binding during stimulation by receptor.

Tang W, Tu Y, Nayak SK, Woodson J, Jehl M, Ross EM.

J Biol Chem. 2006 Feb 24;281(8):4746-53. Epub 2005 Dec 29.

PMID:
16407201
[PubMed - indexed for MEDLINE]
Free Article
14.

A transient interaction between the phosphate binding loop and switch I contributes to the allosteric network between receptor and nucleotide in Gαi1.

Thaker TM, Sarwar M, Preininger AM, Hamm HE, Iverson TM.

J Biol Chem. 2014 Apr 18;289(16):11331-41. doi: 10.1074/jbc.M113.539064. Epub 2014 Mar 4.

PMID:
24596087
[PubMed - indexed for MEDLINE]
15.

The carboxyl terminus of the Galpha-subunit is the latch for triggered activation of heterotrimeric G proteins.

Nanoff C, Koppensteiner R, Yang Q, Fuerst E, Ahorn H, Freissmuth M.

Mol Pharmacol. 2006 Jan;69(1):397-405. Epub 2005 Oct 6.

PMID:
16210429
[PubMed - indexed for MEDLINE]
Free Article
16.

New insights into the role of conserved, essential residues in the GTP binding/GTP hydrolytic cycle of large G proteins.

Majumdar S, Ramachandran S, Cerione RA.

J Biol Chem. 2006 Apr 7;281(14):9219-26. Epub 2006 Feb 9.

PMID:
16469737
[PubMed - indexed for MEDLINE]
Free Article
17.

Mutagenesis in the switch IV of the helical domain of the human Gsalpha reduces its GDP/GTP exchange rate.

Echeverría V, Hinrichs MV, Torrejón M, Ropero S, Martinez J, Toro MJ, Olate J.

J Cell Biochem. 2000 Jan;76(3):368-75.

PMID:
10649434
[PubMed - indexed for MEDLINE]
18.

Signal transfer from GPCRs to G proteins: role of the G alpha N-terminal region in rhodopsin-transducin coupling.

Herrmann R, Heck M, Henklein P, Hofmann KP, Ernst OP.

J Biol Chem. 2006 Oct 6;281(40):30234-41. Epub 2006 Jul 17.

PMID:
16847064
[PubMed - indexed for MEDLINE]
Free Article
19.

Designing point mutants to detect structural coupling in a heterotrimeric G protein alpha-subunit by NMR spectroscopy.

Abdulaev NG, Mao X, Ramon E, Ngo T, Mysliwy J, Marino JP, Ridge KD.

Photochem Photobiol. 2009 Mar-Apr;85(2):431-6. doi: 10.1111/j.1751-1097.2008.00522.x. Epub 2009 Feb 11.

PMID:
19222798
[PubMed - indexed for MEDLINE]
20.

The three-dimensional model of Dictyostelium discoideum racE based on the human rhoA-GDP crystal structure.

Agarwal M, Nelson DJ, Larochelle DA.

J Mol Graph Model. 2002 Aug;21(1):3-18.

PMID:
12413026
[PubMed - indexed for MEDLINE]

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