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Results: 1 to 20 of 153

1.

Enhanced amyloidogenic metabolism of the amyloid beta-protein precursor in the X11L-deficient mouse brain.

Sano Y, Syuzo-Takabatake A, Nakaya T, Saito Y, Tomita S, Itohara S, Suzuki T.

J Biol Chem. 2006 Dec 8;281(49):37853-60. Epub 2006 Oct 10.

PMID:
17032642
[PubMed - indexed for MEDLINE]
Free Article
2.

X11 proteins regulate the translocation of amyloid beta-protein precursor (APP) into detergent-resistant membrane and suppress the amyloidogenic cleavage of APP by beta-site-cleaving enzyme in brain.

Saito Y, Sano Y, Vassar R, Gandy S, Nakaya T, Yamamoto T, Suzuki T.

J Biol Chem. 2008 Dec 19;283(51):35763-71. doi: 10.1074/jbc.M801353200. Epub 2008 Oct 9.

PMID:
18845544
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism.

Araki Y, Tomita S, Yamaguchi H, Miyagi N, Sumioka A, Kirino Y, Suzuki T.

J Biol Chem. 2003 Dec 5;278(49):49448-58. Epub 2003 Sep 12.

PMID:
12972431
[PubMed - indexed for MEDLINE]
Free Article
4.

Amyloid precursor protein processing and retinal pathology in mouse models of Alzheimer's disease.

Dutescu RM, Li QX, Crowston J, Masters CL, Baird PN, Culvenor JG.

Graefes Arch Clin Exp Ophthalmol. 2009 Sep;247(9):1213-21. doi: 10.1007/s00417-009-1060-3. Epub 2009 Mar 7.

PMID:
19271231
[PubMed - indexed for MEDLINE]
5.

Increased amyloidogenic processing of transgenic human APP in X11-like deficient mouse brain.

Kondo M, Shiono M, Itoh G, Takei N, Matsushima T, Maeda M, Taru H, Hata S, Yamamoto T, Saito Y, Suzuki T.

Mol Neurodegener. 2010 Sep 15;5:35. doi: 10.1186/1750-1326-5-35.

PMID:
20843325
[PubMed]
Free PMC Article
6.

Intracellular trafficking of the amyloid β-protein precursor (APP) regulated by novel function of X11-like.

Saito Y, Akiyama M, Araki Y, Sumioka A, Shiono M, Taru H, Nakaya T, Yamamoto T, Suzuki T.

PLoS One. 2011;6(7):e22108. doi: 10.1371/journal.pone.0022108. Epub 2011 Jul 19.

PMID:
21818298
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Facilitation of stress-induced phosphorylation of beta-amyloid precursor protein family members by X11-like/Mint2 protein.

Taru H, Suzuki T.

J Biol Chem. 2004 May 14;279(20):21628-36. Epub 2004 Feb 17.

PMID:
14970211
[PubMed - indexed for MEDLINE]
Free Article
8.

XB51 isoforms mediate Alzheimer's beta-amyloid peptide production by X11L (X11-like protein)-dependent and -independent mechanisms.

Sumioka A, Imoto S, Martins RN, Kirino Y, Suzuki T.

Biochem J. 2003 Aug 15;374(Pt 1):261-8.

PMID:
12780348
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Cryptotanshinone, a compound from Salvia miltiorrhiza modulates amyloid precursor protein metabolism and attenuates beta-amyloid deposition through upregulating alpha-secretase in vivo and in vitro.

Mei Z, Zhang F, Tao L, Zheng W, Cao Y, Wang Z, Tang S, Le K, Chen S, Pi R, Liu P.

Neurosci Lett. 2009 Mar 13;452(2):90-5. doi: 10.1016/j.neulet.2009.01.013. Epub 2009 Jan 13.

PMID:
19154776
[PubMed - indexed for MEDLINE]
10.

A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein.

Schöbel S, Neumann S, Hertweck M, Dislich B, Kuhn PH, Kremmer E, Seed B, Baumeister R, Haass C, Lichtenthaler SF.

J Biol Chem. 2008 May 23;283(21):14257-68. doi: 10.1074/jbc.M801531200. Epub 2008 Mar 19.

PMID:
18353773
[PubMed - indexed for MEDLINE]
Free Article
11.

Vascular endothelial growth factor (VEGF) affects processing of amyloid precursor protein and beta-amyloidogenesis in brain slice cultures derived from transgenic Tg2576 mouse brain.

Bürger S, Noack M, Kirazov LP, Kirazov EP, Naydenov CL, Kouznetsova E, Yafai Y, Schliebs R.

Int J Dev Neurosci. 2009 Oct;27(6):517-23. doi: 10.1016/j.ijdevneu.2009.06.011. Epub 2009 Jul 7.

PMID:
19589380
[PubMed - indexed for MEDLINE]
12.

ADAM10 activation is required for green tea (-)-epigallocatechin-3-gallate-induced alpha-secretase cleavage of amyloid precursor protein.

Obregon DF, Rezai-Zadeh K, Bai Y, Sun N, Hou H, Ehrhart J, Zeng J, Mori T, Arendash GW, Shytle D, Town T, Tan J.

J Biol Chem. 2006 Jun 16;281(24):16419-27. Epub 2006 Apr 19.

PMID:
16624814
[PubMed - indexed for MEDLINE]
Free Article
13.

RNA interference silencing of the adaptor molecules ShcC and Fe65 differentially affect amyloid precursor protein processing and Abeta generation.

Xie Z, Dong Y, Maeda U, Xia W, Tanzi RE.

J Biol Chem. 2007 Feb 16;282(7):4318-25. Epub 2006 Dec 14.

PMID:
17170108
[PubMed - indexed for MEDLINE]
Free Article
14.

Intracellular copper deficiency increases amyloid-beta secretion by diverse mechanisms.

Cater MA, McInnes KT, Li QX, Volitakis I, La Fontaine S, Mercer JF, Bush AI.

Biochem J. 2008 May 15;412(1):141-52. doi: 10.1042/BJ20080103.

PMID:
18248325
[PubMed - indexed for MEDLINE]
Free Article
15.

Phosphorylation of the amino-terminal region of X11L regulates its interaction with APP.

Sakuma M, Tanaka E, Taru H, Tomita S, Gandy S, Nairn AC, Nakaya T, Yamamoto T, Suzuki T.

J Neurochem. 2009 Apr;109(2):465-75. doi: 10.1111/j.1471-4159.2009.05988.x. Epub 2009 Feb 13.

PMID:
19222704
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Coordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation.

Araki Y, Miyagi N, Kato N, Yoshida T, Wada S, Nishimura M, Komano H, Yamamoto T, De Strooper B, Yamamoto K, Suzuki T.

J Biol Chem. 2004 Jun 4;279(23):24343-54. Epub 2004 Mar 22.

PMID:
15037614
[PubMed - indexed for MEDLINE]
Free Article
17.

Excess of nicastrin in brain results in heterozygosity having no effect on endogenous APP processing and amyloid peptide levels in vivo.

Brijbassi S, Amtul Z, Newbigging S, Westaway D, St George-Hyslop P, Rozmahel RF.

Neurobiol Dis. 2007 Feb;25(2):291-6. Epub 2006 Oct 27.

PMID:
17071095
[PubMed - indexed for MEDLINE]
18.

Interaction of a neuron-specific protein containing PDZ domains with Alzheimer's amyloid precursor protein.

Tomita S, Ozaki T, Taru H, Oguchi S, Takeda S, Yagi Y, Sakiyama S, Kirino Y, Suzuki T.

J Biol Chem. 1999 Jan 22;274(4):2243-54.

PMID:
9890987
[PubMed - indexed for MEDLINE]
Free Article
19.

Targeting ADAM10 to lipid rafts in neuroblastoma SH-SY5Y cells impairs amyloidogenic processing of the amyloid precursor protein.

Harris B, Pereira I, Parkin E.

Brain Res. 2009 Nov 3;1296:203-15. doi: 10.1016/j.brainres.2009.07.105. Epub 2009 Aug 11.

PMID:
19679113
[PubMed - indexed for MEDLINE]
20.

In vivo beta-secretase 1 inhibition leads to brain Abeta lowering and increased alpha-secretase processing of amyloid precursor protein without effect on neuregulin-1.

Sankaranarayanan S, Price EA, Wu G, Crouthamel MC, Shi XP, Tugusheva K, Tyler KX, Kahana J, Ellis J, Jin L, Steele T, Stachel S, Coburn C, Simon AJ.

J Pharmacol Exp Ther. 2008 Mar;324(3):957-69. Epub 2007 Dec 21.

PMID:
18156464
[PubMed - indexed for MEDLINE]
Free Article
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