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17013637,11862344,2459370,15500597,11981600,7853176,8632309,10511067,9580575,15099664,17517480,11351930,10928310,8689806,16756415,1376362,15769555,28655025,17109303,27012435,16764215,16203961,9146820,9179510,12237786,12954743,7542336,1383825,20150662,9589267,7504098,21749526,15664721,8768738,17854341,17306725,18831352,27267785,17605004,18087797,15223097,20450242,2467983,18469544,19948382,18042474,20450241,19708849,17109310,8819498,15111917,23647815,21434580,20450243,9952063,2457074,16144748,16930865,18503626,16956874,16814937,8463453,16191667,26650971,19403243,12762334,15204675,8930154,16919747,24129113,20403021,26639678,17211652,17919544,2447262,20589494,30295400,15561466,17400414,16456085,17414244,7519977,20130408,21270789,16612211,17568402,11064186,17389539,15607843,8138958,15943939,10372215,16185211,18423901,23707283,20577717,28700791,18411237,17541066,30157924,11399214,20728384,16311183,20450244,17564877,11847954,24227768,26110375,18327673,9085402,17064857,10525745,11187226,30079432,15072805,16191669,20632700,36149002,15534969,16719249,16490679,17624687,23293011,1731046,25321188,18190664,15020097,12092171,16950210,12653813,1406906,9566806,16191668,18803988,18443666,15266952,19800758,1609037,29247974,32162420,15370011,15036544,31769109,25510513,1876130,10463317,17596905,18071169,19923837,25823919,25156759,23317685,14621343,35731889,20881947,11919661,18355989,22079773,18706410,17109309,9353405,17055191,30133422,10809268,33617752,31753622,19615925,19393843,25295655,16025322,17784896,10908521,22559256,7802310,12633918,20359843,26454835,27435437,12028854,8164503,17015570,14660133,15080765,16318959,30526648,22456493,21395892,14687955,16413146,18762438,10529020,20666206,27434441,15495026,20940383,18720267,16432270,1406908,12189003,35916416,25823907,26918662,20699077,11470347,10991968,35112990,20106601,12592214,22475985,25555887,8823239,12762216,12954740,30418214,30355476,16499515,12740181,20921918,16366759,18331121,25432908,16953647,23855333,28514235,31197606,23161001,35266779,11875630,25783757,30773411,16702892,16158910,16002025,17364425,19538000,17109305,34775907,16148422,21854290,21565452,16445556,15181649,34789683,11123005,8861402,12738347,32033582,28290640,15781180,16616162,12738351,12028743,12910029,10336539,10402160,12076434,14621350,8373940,11110064,17682629,16627301,22614935,14504022,16524668,15099916,2453895,33818748,15279124,26312959,11512037,32546067,29278818,32145041,14626165,18286804,9316825,15366107,2701308,32460142,22175698,11444154,28468077,34520037,15921996,23617861,1629388,16756418,20307796,31706250,18552728,27788815,19739698,11292003,15500559,26483357,15240031,32781310,1715035,20091529,31274259,16493098,28070862,18984896,25060839,18559110,27687214,23512803,27234658,10669065,30616926,31814186,32572978,18634811,22263712,28669739,12439626,25179217,19149822,10665107,28554599,25251308,22882389,2323312,20307799,27271032,215096,25282598,32858563,17050900,32925232,29148881,34173647,12902992,14578021,10529021,33480051,10962771,15279126,25198209,31626394,29944481,20980992,16493097,35963210,33476917,9684393,7675960,15362084,20155591,1876075,21466501,7734458,2901137,9190848,31732373,16536895,30531584,28521199,14556390,36738100,21795869,31060846,7076369,21741781,2328561,9608349,11454944,2675644,19402772,31336328,16719242,31513980,16600506,21596492,11134491,23489947,23528523,16854666,9767201,31370976,21838837,8866702,28930773,24944070,17367258,23839029,19089508,10836211,3959968,25826044,15717347,32970572,8173501,3136361,19647958,29543612,34954746,2457160,12495804,36195895,19574017,10402152,25823632,34559090,1561479,14556389,16639978,26604818,16183444,22564847,11906798,29016376,27712113,2323306,25162607,2441722,23692014,27870477,15556824,20390696,34864788,16502886,15354595,33404150,29710138,14698800,32985850,29064938,24713865,15377814,11042867,15140632,16546596,32435865,24313239,25267606,26059463,36731102,12739412,16809994,16536900,33334955,16324802,12369590,9852372,9809131,25794231,11224407,2180244,378645,20537815,24985936,34030027,32960820,26234590,27692193,33352498,26009867,22165036,16844959,33378137,10942856,36630319,29673620,30379781,33156706,25975386,1217693,16113176,3052153,2449617,33215939,16076037,2393441,25015174,32302475,9258859,16787825,16616994,28593748,16203962,32110522,9767204,32530885,28441273,26917621,25908321,2369960,15236821,27992,15730815,36810193,34818471,187095,16468244,1396108,8726544,17695670,15269931,24628996,12109409,28301697,34247265,19833435,9143642,30747750,35940992,18444447,2279212,11693143,23481062,36301466,7395601,36523200,31107,25619263,32216889,8836612,6298150,12021739,2600989,3256401,28267949,32122979,28951506,16610414,27806420,16294560,28067687,24273683,19464125,34524778,6844227,6181412,16203405,3471262,56139,25629812,32297787,23244430,36810157,25664200,35169229,31125192,15703716,17591317,16781931,38415,11224099,31229393,2717980,7427339,35271484,27690553,11763019,9654,29929656,6176658,15632548,4351589,34804741,23074230,31904630,30653478,6181413,11915824,21743710,20164524,35776889,29481439,21266627,35604061,35001534,29103795,35977731,25675074,20788660[uid]

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Effects associated with double-blind omission of buprenorphine/naloxone over a 98-h period.

Correia CJ, Walsh SL, Bigelow GE, Strain EC. Correia CJ, et al. Psychopharmacology (Berl). 2006 Dec;189(3):297-306. doi: 10.1007/s00213-006-0571-4. Epub 2006 Sep 30. Psychopharmacology (Berl). 2006. PMID: 17013637 Clinical Trial.

Blockade of hydromorphone effects by buprenorphine/naloxone and buprenorphine.

Strain EC, Walsh SL, Bigelow GE. Strain EC, et al. Psychopharmacology (Berl). 2002 Jan;159(2):161-6. doi: 10.1007/s002130100920. Epub 2001 Oct 12. Psychopharmacology (Berl). 2002. PMID: 11862344 Clinical Trial.

Buprenorphine: dose-related blockade of opioid challenge effects in opioid dependent humans.

Bickel WK, Stitzer ML, Bigelow GE, Liebson IA, Jasinski DR, Johnson RE. Bickel WK, et al. J Pharmacol Exp Ther. 1988 Oct;247(1):47-53. J Pharmacol Exp Ther. 1988. PMID: 2459370

Evaluation of an injection depot formulation of buprenorphine: placebo comparison.

Sigmon SC, Wong CJ, Chausmer AL, Liebson IA, Bigelow GE. Sigmon SC, et al. Addiction. 2004 Nov;99(11):1439-49. doi: 10.1111/j.1360-0443.2004.00834.x. Addiction. 2004. PMID: 15500597 Clinical Trial.

High-dose methadone produces superior opioid blockade and comparable withdrawal suppression to lower doses in opioid-dependent humans.

Donny EC, Walsh SL, Bigelow GE, Eissenberg T, Stitzer ML. Donny EC, et al. Psychopharmacology (Berl). 2002 May;161(2):202-12. doi: 10.1007/s00213-002-1027-0. Epub 2002 Mar 13. Psychopharmacology (Berl). 2002. PMID: 11981600

Buprenorphine effects in methadone-maintained volunteers: effects at two hours after methadone.

Strain EC, Preston KL, Liebson IA, Bigelow GE. Strain EC, et al. J Pharmacol Exp Ther. 1995 Feb;272(2):628-38. J Pharmacol Exp Ther. 1995. PMID: 7853176

Buprenorphine's physical dependence potential: antagonist-precipitated withdrawal in humans.

Eissenberg T, Greenwald MK, Johnson RE, Liebson IA, Bigelow GE, Stitzer ML. Eissenberg T, et al. J Pharmacol Exp Ther. 1996 Feb;276(2):449-59. J Pharmacol Exp Ther. 1996. PMID: 8632309

A comparison of four buprenorphine dosing regimens in the treatment of opioid dependence.

Petry NM, Bickel WK, Badger GJ. Petry NM, et al. Clin Pharmacol Ther. 1999 Sep;66(3):306-14. doi: 10.1016/S0009-9236(99)70039-1. Clin Pharmacol Ther. 1999. PMID: 10511067 Clinical Trial.

Dose-response analysis of opioid cross-tolerance and withdrawal suppression during LAAM maintenance.

Houtsmuller EJ, Walsh SL, Schuh KJ, Johnson RE, Stitzer ML, Bigelow GE. Houtsmuller EJ, et al. J Pharmacol Exp Ther. 1998 May;285(2):387-96. J Pharmacol Exp Ther. 1998. PMID: 9580575 Clinical Trial.

A dose-effect study of repeated administration of buprenorphine/naloxone on performance in opioid-dependent volunteers.

Mintzer MZ, Correia CJ, Strain EC. Mintzer MZ, et al. Drug Alcohol Depend. 2004 May 10;74(2):205-9. doi: 10.1016/j.drugalcdep.2003.12.008. Drug Alcohol Depend. 2004. PMID: 15099664 Clinical Trial.

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