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Items: 1 to 20 of 74

1.

The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease.

Lamb J, Crawford ED, Peck D, Modell JW, Blat IC, Wrobel MJ, Lerner J, Brunet JP, Subramanian A, Ross KN, Reich M, Hieronymus H, Wei G, Armstrong SA, Haggarty SJ, Clemons PA, Wei R, Carr SA, Lander ES, Golub TR.

Science. 2006 Sep 29;313(5795):1929-35.

2.

Connecting the dots using gene-expression profiles.

Gullans SR.

N Engl J Med. 2006 Nov 9;355(19):2042-4. No abstract available.

PMID:
17093257
3.

A simple and robust method for connecting small-molecule drugs using gene-expression signatures.

Zhang SD, Gant TW.

BMC Bioinformatics. 2008 Jun 2;9:258. doi: 10.1186/1471-2105-9-258.

4.

Histone deacetylase 1 gene expression and sensitization of multidrug-resistant neuroblastoma cell lines to cytotoxic agents by depsipeptide.

Keshelava N, Davicioni E, Wan Z, Ji L, Sposto R, Triche TJ, Reynolds CP.

J Natl Cancer Inst. 2007 Jul 18;99(14):1107-19. Epub 2007 Jul 10.

5.

Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance.

Wei G, Twomey D, Lamb J, Schlis K, Agarwal J, Stam RW, Opferman JT, Sallan SE, den Boer ML, Pieters R, Golub TR, Armstrong SA.

Cancer Cell. 2006 Oct;10(4):331-42. Epub 2006 Sep 28.

6.

Treatment-specific changes in gene expression discriminate in vivo drug response in human leukemia cells.

Cheok MH, Yang W, Pui CH, Downing JR, Cheng C, Naeve CW, Relling MV, Evans WE.

Nat Genet. 2003 May;34(1):85-90. Erratum in: Nat Genet. 2003 Jun;34(2):231.

PMID:
12704389
7.

Querying genomic databases: refining the connectivity map.

Segal MR, Xiong H, Bengtsson H, Bourgon R, Gentleman R.

Stat Appl Genet Mol Biol. 2012 Jan 6;11(2). pii: /j/sagmb.2012.11.issue-2/1544-6115.1715/1544-6115.1715.xml. doi: 10.2202/1544-6115.1715.

PMID:
22499690
8.

sscMap: an extensible Java application for connecting small-molecule drugs using gene-expression signatures.

Zhang SD, Gant TW.

BMC Bioinformatics. 2009 Jul 31;10:236. doi: 10.1186/1471-2105-10-236.

9.

Histone deacetylase inhibitor panobinostat induces clinical responses with associated alterations in gene expression profiles in cutaneous T-cell lymphoma.

Ellis L, Pan Y, Smyth GK, George DJ, McCormack C, Williams-Truax R, Mita M, Beck J, Burris H, Ryan G, Atadja P, Butterfoss D, Dugan M, Culver K, Johnstone RW, Prince HM.

Clin Cancer Res. 2008 Jul 15;14(14):4500-10. doi: 10.1158/1078-0432.CCR-07-4262.

10.

Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators.

Hieronymus H, Lamb J, Ross KN, Peng XP, Clement C, Rodina A, Nieto M, Du J, Stegmaier K, Raj SM, Maloney KN, Clardy J, Hahn WC, Chiosis G, Golub TR.

Cancer Cell. 2006 Oct;10(4):321-30. Epub 2006 Sep 28.

11.

GEM-TREND: a web tool for gene expression data mining toward relevant network discovery.

Feng C, Araki M, Kunimoto R, Tamon A, Makiguchi H, Niijima S, Tsujimoto G, Okuno Y.

BMC Genomics. 2009 Sep 3;10:411. doi: 10.1186/1471-2164-10-411.

12.

Histone deacetylase (HDAC) encoding gene expression in pancreatic cancer cell lines and cell sensitivity to HDAC inhibitors.

Ouaïssi M, Cabral S, Tavares J, da Silva AC, Mathieu Daude F, Mas E, Bernard J, Sastre B, Lombardo D, Ouaissi A.

Cancer Biol Ther. 2008 Apr;7(4):523-31. Epub 2008 Jan 2.

PMID:
18296916
13.

Gene expression profiling of leukemia T-cells resistant to methotrexate and 7-hydroxymethotrexate reveals alterations that preserve intracellular levels of folate and nucleotide biosynthesis.

Fotoohi AK, Assaraf YG, Moshfegh A, Hashemi J, Jansen G, Peters GJ, Larsson C, Albertioni F.

Biochem Pharmacol. 2009 Apr 15;77(8):1410-7. doi: 10.1016/j.bcp.2008.12.026. Epub 2009 Jan 19.

PMID:
19426680
14.

Histone deacetylase inhibitors induce a very broad, pleiotropic anticancer drug resistance phenotype in acute myeloid leukemia cells by modulation of multiple ABC transporter genes.

Hauswald S, Duque-Afonso J, Wagner MM, Schertl FM, Lübbert M, Peschel C, Keller U, Licht T.

Clin Cancer Res. 2009 Jun 1;15(11):3705-15. doi: 10.1158/1078-0432.CCR-08-2048. Epub 2009 May 19.

15.

In vivo anti-myeloma activity and modulation of gene expression profile induced by valproic acid, a histone deacetylase inhibitor.

Neri P, Tagliaferri P, Di Martino MT, Calimeri T, Amodio N, Bulotta A, Ventura M, Eramo PO, Viscomi C, Arbitrio M, Rossi M, Caraglia M, Munshi NC, Anderson KC, Tassone P.

Br J Haematol. 2008 Nov;143(4):520-31. doi: 10.1111/j.1365-2141.2008.07387.x.

PMID:
18986388
16.

Two independent gene signatures in pediatric t(4;11) acute lymphoblastic leukemia patients.

Trentin L, Giordan M, Dingermann T, Basso G, Te Kronnie G, Marschalek R.

Eur J Haematol. 2009 Nov;83(5):406-19. doi: 10.1111/j.1600-0609.2009.01305.x. Epub 2009 Jun 25.

PMID:
19558506
17.

Antitumor activity of histone deacetylase inhibitors in non-small cell lung cancer cells: development of a molecular predictive model.

Miyanaga A, Gemma A, Noro R, Kataoka K, Matsuda K, Nara M, Okano T, Seike M, Yoshimura A, Kawakami A, Uesaka H, Nakae H, Kudoh S.

Mol Cancer Ther. 2008 Jul;7(7):1923-30. doi: 10.1158/1535-7163.MCT-07-2140. Epub 2008 Jul 7.

18.

MS-275, a novel histone deacetylase inhibitor with selectivity against HDAC1, induces degradation of FLT3 via inhibition of chaperone function of heat shock protein 90 in AML cells.

Nishioka C, Ikezoe T, Yang J, Takeuchi S, Koeffler HP, Yokoyama A.

Leuk Res. 2008 Sep;32(9):1382-92. doi: 10.1016/j.leukres.2008.02.018. Epub 2008 Apr 3.

PMID:
18394702
19.

Alterations in gamma-actin and tubulin-targeted drug resistance in childhood leukemia.

Verrills NM, Po'uha ST, Liu ML, Liaw TY, Larsen MR, Ivery MT, Marshall GM, Gunning PW, Kavallaris M.

J Natl Cancer Inst. 2006 Oct 4;98(19):1363-74.

20.

Characterization of B- and T-lineage acute lymphoblastic leukemia by integrated analysis of MicroRNA and mRNA expression profiles.

Fulci V, Colombo T, Chiaretti S, Messina M, Citarella F, Tavolaro S, Guarini A, Foà R, Macino G.

Genes Chromosomes Cancer. 2009 Dec;48(12):1069-82. doi: 10.1002/gcc.20709.

PMID:
19760605
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