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Results: 1 to 20 of 182

1.

SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity.

Jacinto E, Facchinetti V, Liu D, Soto N, Wei S, Jung SY, Huang Q, Qin J, Su B.

Cell. 2006 Oct 6;127(1):125-37. Epub 2006 Sep 7.

PMID:
16962653
[PubMed - indexed for MEDLINE]
Free Article
2.

PRR5, a novel component of mTOR complex 2, regulates platelet-derived growth factor receptor beta expression and signaling.

Woo SY, Kim DH, Jun CB, Kim YM, Haar EV, Lee SI, Hegg JW, Bandhakavi S, Griffin TJ, Kim DH.

J Biol Chem. 2007 Aug 31;282(35):25604-12. Epub 2007 Jun 28.

PMID:
17599906
[PubMed - indexed for MEDLINE]
Free Article
3.

Cytoplasmic and nuclear distribution of the protein complexes mTORC1 and mTORC2: rapamycin triggers dephosphorylation and delocalization of the mTORC2 components rictor and sin1.

Rosner M, Hengstschläger M.

Hum Mol Genet. 2008 Oct 1;17(19):2934-48. doi: 10.1093/hmg/ddn192. Epub 2008 Jul 8.

PMID:
18614546
[PubMed - indexed for MEDLINE]
Free Article
4.

Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity.

Yang Q, Inoki K, Ikenoue T, Guan KL.

Genes Dev. 2006 Oct 15;20(20):2820-32.

PMID:
17043309
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Human cytomegalovirus infection alters the substrate specificities and rapamycin sensitivities of raptor- and rictor-containing complexes.

Kudchodkar SB, Yu Y, Maguire TG, Alwine JC.

Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14182-7. Epub 2006 Sep 7.

PMID:
16959881
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling.

Ikenoue T, Inoki K, Yang Q, Zhou X, Guan KL.

EMBO J. 2008 Jul 23;27(14):1919-31. doi: 10.1038/emboj.2008.119. Epub 2008 Jun 19. Erratum in: EMBO J. 2008 Aug 20;27(16):2270.

PMID:
18566587
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Hypoxia-induced endothelial proliferation requires both mTORC1 and mTORC2.

Li W, Petrimpol M, Molle KD, Hall MN, Battegay EJ, Humar R.

Circ Res. 2007 Jan 5;100(1):79-87. Epub 2006 Nov 16.

PMID:
17110594
[PubMed - indexed for MEDLINE]
Free Article
8.

TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function.

Schalm SS, Fingar DC, Sabatini DM, Blenis J.

Curr Biol. 2003 May 13;13(10):797-806.

PMID:
12747827
[PubMed - indexed for MEDLINE]
9.

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.

Sarbassov DD, Guertin DA, Ali SM, Sabatini DM.

Science. 2005 Feb 18;307(5712):1098-101.

PMID:
15718470
[PubMed - indexed for MEDLINE]
Free Article
10.

Raptor-rictor axis in TGFbeta-induced protein synthesis.

Das F, Ghosh-Choudhury N, Mahimainathan L, Venkatesan B, Feliers D, Riley DJ, Kasinath BS, Choudhury GG.

Cell Signal. 2008 Feb;20(2):409-23. Epub 2007 Nov 7.

PMID:
18068336
[PubMed - indexed for MEDLINE]
11.

mTOR-rictor is the Ser473 kinase for AKT1 in mouse one-cell stage embryos.

Zhang Z, Zhang G, Xu X, Su W, Yu B.

Mol Cell Biochem. 2012 Feb;361(1-2):249-57. doi: 10.1007/s11010-011-1110-0. Epub 2011 Nov 5.

PMID:
22057724
[PubMed - indexed for MEDLINE]
12.

Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size.

Trendelenburg AU, Meyer A, Rohner D, Boyle J, Hatakeyama S, Glass DJ.

Am J Physiol Cell Physiol. 2009 Jun;296(6):C1258-70. doi: 10.1152/ajpcell.00105.2009. Epub 2009 Apr 8.

PMID:
19357233
[PubMed - indexed for MEDLINE]
Free Article
13.

Acetaldehyde promotes rapamycin-dependent activation of p70(S6K) and glucose uptake despite inhibition of Akt and mTOR in dopaminergic SH-SY5Y human neuroblastoma cells.

Fang CX, Yang X, Sreejayan N, Ren J.

Exp Neurol. 2007 Jan;203(1):196-204. Epub 2006 Sep 7.

PMID:
16962100
[PubMed - indexed for MEDLINE]
14.

Involvement of mTORC1 and mTORC2 in regulation of glioblastoma multiforme growth and motility.

Gulati N, Karsy M, Albert L, Murali R, Jhanwar-Uniyal M.

Int J Oncol. 2009 Oct;35(4):731-40.

PMID:
19724909
[PubMed - indexed for MEDLINE]
15.

Receptor-specific mechanisms regulate phosphorylation of AKT at Ser473: role of RICTOR in β1 integrin-mediated cell survival.

Riaz A, Zeller KS, Johansson S.

PLoS One. 2012;7(2):e32081. doi: 10.1371/journal.pone.0032081. Epub 2012 Feb 22.

PMID:
22384145
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability.

Shiota C, Woo JT, Lindner J, Shelton KD, Magnuson MA.

Dev Cell. 2006 Oct;11(4):583-9. Epub 2006 Sep 7.

PMID:
16962829
[PubMed - indexed for MEDLINE]
Free Article
17.

Signalling mechanisms mediated by the phosphoinositide 3-kinase/Akt cascade in synaptic plasticity and memory in the rat.

Horwood JM, Dufour F, Laroche S, Davis S.

Eur J Neurosci. 2006 Jun;23(12):3375-84.

PMID:
16820027
[PubMed - indexed for MEDLINE]
18.

mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes.

Hresko RC, Mueckler M.

J Biol Chem. 2005 Dec 9;280(49):40406-16. Epub 2005 Oct 11.

PMID:
16221682
[PubMed - indexed for MEDLINE]
Free Article
19.

Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40.

Vander Haar E, Lee SI, Bandhakavi S, Griffin TJ, Kim DH.

Nat Cell Biol. 2007 Mar;9(3):316-23. Epub 2007 Feb 4.

PMID:
17277771
[PubMed - indexed for MEDLINE]
20.

Rapamycin inhibits cell motility by suppression of mTOR-mediated S6K1 and 4E-BP1 pathways.

Liu L, Li F, Cardelli JA, Martin KA, Blenis J, Huang S.

Oncogene. 2006 Nov 9;25(53):7029-40. Epub 2006 May 22.

PMID:
16715128
[PubMed - indexed for MEDLINE]

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