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Items: 1 to 20 of 78

1.

p16INK4a induces an age-dependent decline in islet regenerative potential.

Krishnamurthy J, Ramsey MR, Ligon KL, Torrice C, Koh A, Bonner-Weir S, Sharpless NE.

Nature. 2006 Sep 28;443(7110):453-7. Epub 2006 Sep 6.

PMID:
16957737
2.

p38MAPK controls expression of multiple cell cycle inhibitors and islet proliferation with advancing age.

Wong ES, Le Guezennec X, Demidov ON, Marshall NT, Wang ST, Krishnamurthy J, Sharpless NE, Dunn NR, Bulavin DV.

Dev Cell. 2009 Jul;17(1):142-9. doi: 10.1016/j.devcel.2009.05.009.

3.

Ageing: balancing regeneration and cancer.

Beausejour CM, Campisi J.

Nature. 2006 Sep 28;443(7110):404-5. No abstract available.

PMID:
16957734
4.

Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a.

Janzen V, Forkert R, Fleming HE, Saito Y, Waring MT, Dombkowski DM, Cheng T, DePinho RA, Sharpless NE, Scadden DT.

Nature. 2006 Sep 28;443(7110):421-6. Epub 2006 Sep 6.

PMID:
16957735
5.

Polycomb protein Ezh2 regulates pancreatic beta-cell Ink4a/Arf expression and regeneration in diabetes mellitus.

Chen H, Gu X, Su IH, Bottino R, Contreras JL, Tarakhovsky A, Kim SK.

Genes Dev. 2009 Apr 15;23(8):975-85. doi: 10.1101/gad.1742509.

6.

Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing.

Molofsky AV, Slutsky SG, Joseph NM, He S, Pardal R, Krishnamurthy J, Sharpless NE, Morrison SJ.

Nature. 2006 Sep 28;443(7110):448-52. Epub 2006 Sep 6.

7.

IGF-I mediates regeneration of endocrine pancreas by increasing beta cell replication through cell cycle protein modulation in mice.

Agudo J, Ayuso E, Jimenez V, Salavert A, Casellas A, Tafuro S, Haurigot V, Ruberte J, Segovia JC, Bueren J, Bosch F.

Diabetologia. 2008 Oct;51(10):1862-72. doi: 10.1007/s00125-008-1087-8. Epub 2008 Jul 29.

PMID:
18663428
8.

Comparative study of regenerative potential of beta cells from young and aged donor mice using a novel islet transplantation model.

Chen X, Zhang X, Chen F, Larson CS, Wang LJ, Kaufman DB.

Transplantation. 2009 Aug 27;88(4):496-503. doi: 10.1097/TP.0b013e3181b0d2ee. Erratum in: Transplantation. 2009 Sep 27;88(6):853.

PMID:
19696632
9.

Age differences in cyclin-dependent kinase inhibitor expression and rb hyperphosphorylation in human corneal endothelial cells.

Enomoto K, Mimura T, Harris DL, Joyce NC.

Invest Ophthalmol Vis Sci. 2006 Oct;47(10):4330-40.

PMID:
17003423
10.

p16INK4A is a robust in vivo biomarker of cellular aging in human skin.

Ressler S, Bartkova J, Niederegger H, Bartek J, Scharffetter-Kochanek K, Jansen-Dürr P, Wlaschek M.

Aging Cell. 2006 Oct;5(5):379-89. Epub 2006 Aug 15.

11.

Overexpression of cyclin D1 in pancreatic beta-cells in vivo results in islet hyperplasia without hypoglycemia.

Zhang X, Gaspard JP, Mizukami Y, Li J, Graeme-Cook F, Chung DC.

Diabetes. 2005 Mar;54(3):712-9.

12.

Expression of senescence-related genes in human corneal endothelial cells.

Song Z, Wang Y, Xie L, Zang X, Yin H.

Mol Vis. 2008 Jan 29;14:161-70.

13.

Does IGF-I stimulate pancreatic islet cell growth?

Liu JL.

Cell Biochem Biophys. 2007;48(2-3):115-25.

PMID:
17709881
14.

Expression of a mutant p53 results in an age-related demographic shift in spontaneous lung tumor formation in transgenic mice.

Duan W, Gao L, Wu X, Hade EM, Gao JX, Ding H, Barsky SH, Otterson GA, Villalona-Calero MA.

PLoS One. 2009;4(5):e5563. doi: 10.1371/journal.pone.0005563. Epub 2009 May 15.

15.

A new mechanism of release from senescence: suppression of p16INK4a by beta-catenin.

Curley DP, Bosenberg MW.

Pigment Cell Melanoma Res. 2008 Feb;21(1):5-6. doi: 10.1111/j.1755-148X.2007.00434.x. No abstract available.

PMID:
18353136
16.

Does p16ink4a expression increase with the number of cell doublings in normal and malignant lymphocytes?

Chebel A, Chien WW, Gerland LM, Mekki Y, Bertrand Y, Ffrench P, Galmarini CM, Ffrench M.

Leuk Res. 2007 Dec;31(12):1649-58. Epub 2007 May 1.

PMID:
17475325
17.

Relationship between expression and methylation status of p16INK4a and the proliferative activity of different areas' tumour cells in human colorectal cancer.

Jie G, Zhixiang S, Lei S, Hesheng L, Xiaojun T.

Int J Clin Pract. 2007 Sep;61(9):1523-9. Epub 2007 May 30.

PMID:
17537196
18.

Increased expression of senescence-associated cell cycle inhibitor p16INK4a in deteriorating renal transplants and diseased native kidney.

Melk A, Schmidt BM, Vongwiwatana A, Rayner DC, Halloran PF.

Am J Transplant. 2005 Jun;5(6):1375-82.

19.

p15Ink4b is a critical tumour suppressor in the absence of p16Ink4a.

Krimpenfort P, Ijpenberg A, Song JY, van der Valk M, Nawijn M, Zevenhoven J, Berns A.

Nature. 2007 Aug 23;448(7156):943-6.

PMID:
17713536
20.

PTEN controls β-cell regeneration in aged mice by regulating cell cycle inhibitor p16ink4a.

Zeng N, Yang KT, Bayan JA, He L, Aggarwal R, Stiles JW, Hou X, Medina V, Abad D, Palian BM, Al-Abdullah I, Kandeel F, Johnson DL, Stiles BL.

Aging Cell. 2013 Dec;12(6):1000-11. doi: 10.1111/acel.12132. Epub 2013 Aug 6.

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