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LPS-induced TNF-alpha factor (LITAF)-deficient mice express reduced LPS-induced cytokine: Evidence for LITAF-dependent LPS signaling pathways.

Tang X, Metzger D, Leeman S, Amar S.

Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13777-82. Epub 2006 Sep 5. Erratum in: Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):3015.


Whole-body deletion of LPS-induced TNF-α factor (LITAF) markedly improves experimental endotoxic shock and inflammatory arthritis.

Merrill JC, You J, Constable C, Leeman SE, Amar S.

Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):21247-52. doi: 10.1073/pnas.1111492108. Epub 2011 Dec 12.


Dynamic regulation of pro- and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses.

Chi H, Barry SP, Roth RJ, Wu JJ, Jones EA, Bennett AM, Flavell RA.

Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2274-9. Epub 2006 Feb 6.


Induction of in vitro reprogramming by Toll-like receptor (TLR)2 and TLR4 agonists in murine macrophages: effects of TLR "homotolerance" versus "heterotolerance" on NF-kappa B signaling pathway components.

Dobrovolskaia MA, Medvedev AE, Thomas KE, Cuesta N, Toshchakov V, Ren T, Cody MJ, Michalek SM, Rice NR, Vogel SN.

J Immunol. 2003 Jan 1;170(1):508-19.


Quercetin disrupts tyrosine-phosphorylated phosphatidylinositol 3-kinase and myeloid differentiation factor-88 association, and inhibits MAPK/AP-1 and IKK/NF-κB-induced inflammatory mediators production in RAW 264.7 cells.

Endale M, Park SC, Kim S, Kim SH, Yang Y, Cho JY, Rhee MH.

Immunobiology. 2013 Dec;218(12):1452-67. doi: 10.1016/j.imbio.2013.04.019. Epub 2013 May 9.


Minocycline ameliorates LPS-induced inflammation in human monocytes by novel mechanisms including LOX-1, Nur77 and LITAF inhibition.

Pang T, Wang J, Benicky J, Saavedra JM.

Biochim Biophys Acta. 2012 Apr;1820(4):503-10. doi: 10.1016/j.bbagen.2012.01.011. Epub 2012 Jan 27.


Distinct pathways of LPS-induced NF-kappa B activation and cytokine production in human myeloid and nonmyeloid cells defined by selective utilization of MyD88 and Mal/TIRAP.

Andreakos E, Sacre SM, Smith C, Lundberg A, Kiriakidis S, Stonehouse T, Monaco C, Feldmann M, Foxwell BM.

Blood. 2004 Mar 15;103(6):2229-37. Epub 2003 Nov 20.


The role of MyD88 and TLR4 in the LPS-mimetic activity of Taxol.

Byrd-Leifer CA, Block EF, Takeda K, Akira S, Ding A.

Eur J Immunol. 2001 Aug;31(8):2448-57.


Beneficial dysregulation of the time course of inflammatory mediators in lipopolysaccharide-induced tumor necrosis factor alpha factor-deficient mice.

Srinivasan S, Leeman SE, Amar S.

Clin Vaccine Immunol. 2010 May;17(5):699-704. doi: 10.1128/CVI.00510-09. Epub 2010 Mar 10.


Flavopiridol inhibits lipopolysaccharide-induced TNF-α production through inactivation of nuclear factor-κB and mitogen-activated protein kinases in the MyD88-dependent pathway.

Haque A, Koide N, Iftakhar-E-Khuda I, Noman AS, Odkhuu E, Badamtseren B, Naiki Y, Komatsu T, Yoshida T, Yokochi T.

Microbiol Immunol. 2011 Mar;55(3):160-7. doi: 10.1111/j.1348-0421.2010.00304.x.


Uropathogenic Escherichia coli block MyD88-dependent and activate MyD88-independent signaling pathways in rat testicular cells.

Bhushan S, Tchatalbachev S, Klug J, Fijak M, Pineau C, Chakraborty T, Meinhardt A.

J Immunol. 2008 Apr 15;180(8):5537-47.


Melatonin modulates TLR4-mediated inflammatory genes through MyD88- and TRIF-dependent signaling pathways in lipopolysaccharide-stimulated RAW264.7 cells.

Xia MZ, Liang YL, Wang H, Chen X, Huang YY, Zhang ZH, Chen YH, Zhang C, Zhao M, Xu DX, Song LH.

J Pineal Res. 2012 Nov;53(4):325-34. doi: 10.1111/j.1600-079X.2012.01002.x. Epub 2012 Apr 27.


Thalidomide inhibits lipopolysaccharide-induced tumor necrosis factor-alpha production via down-regulation of MyD88 expression.

Noman AS, Koide N, Hassan F, I-E-Khuda I, Dagvadorj J, Tumurkhuu G, Islam S, Naiki Y, Yoshida T, Yokochi T.

Innate Immun. 2009 Feb;15(1):33-41. doi: 10.1177/1753425908099317.


β(2) integrins inhibit TLR responses by regulating NF-κB pathway and p38 MAPK activation.

Yee NK, Hamerman JA.

Eur J Immunol. 2013 Mar;43(3):779-92. doi: 10.1002/eji.201242550. Epub 2013 Feb 11.


Lipopolysaccharide (LPS) of Porphyromonas gingivalis induces IL-1beta, TNF-alpha and IL-6 production by THP-1 cells in a way different from that of Escherichia coli LPS.

Diya Zhang, Lili Chen, Shenglai Li, Zhiyuan Gu, Jie Yan.

Innate Immun. 2008 Apr;14(2):99-107. doi: 10.1177/1753425907088244.


Signaling pathways for tumor necrosis factor-alpha and interleukin-6 expression in human macrophages exposed to titanium-alloy particulate debris in vitro.

Nakashima Y, Sun DH, Trindade MC, Maloney WJ, Goodman SB, Schurman DJ, Smith RL.

J Bone Joint Surg Am. 1999 May;81(5):603-15.

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